Preliminary clinical randomized controlled trial on knee osteoarthritis treated with moxibustion

Ren, Xiumei; Cao, Jinjin; Shen, Xueyong; Wang, Lizhen; Zhao, Ling; Wu, Fan; Zhang, Haimeng

doi:10.1016/s1003-5257(12)60024-5

Cited by 6 publications

(2 citation statements)

References 9 publications

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“…Based on the results of a study investigating moxibustion versus a heat-insulated placebo moxibustion for KOA [22], we assumed a standard deviation of 10 for group C (sham moxibustion), and 12 for groups A and B (moxibustion). The sample size calculation was based on the formula of one-way analysis of variance (ANOVA) with pairwise comparisons, with 80% power, a two-sided significance level of 5% and a 15% dropout rate.…”

Section: Methodsmentioning

confidence: 99%

Moxibustion using different habitat moxa floss for moderate to severe primary knee osteoarthritis: study protocol for a three-armed randomized, double-blinded, sham-controlled trial

Zhao

Kang

et al. 2018

Trials

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BackgroundAccording to the traditional Chinese medicine theory, moxa floss is the best material for moxibustion; the effect of moxibustion is closely related to the habitats of moxa floss, among which Qichun County, Hubei Province, China, is considered as the genuine origin. However, this view has not been validated by clinical studies. Moxibustion has been proven effective in alleviating pain and improving physical function and quality of life for patients with knee osteoarthritis (KOA). This trial aims to determine whether the habitat of moxa floss contributes to the effect of moxibustion and to validate the effectiveness of moxibustion for KOA.MethodsThis is a three-armed, randomized, double-blinded, sham-controlled trial. A total of 350 patients with moderate to severe primary KOA will be randomly allocated to groups A, B, or C with a 2:2:1 ratio. Moxa stick moxibustion using moxa floss from different habitats will be applied in two experimental groups: group A, moxa floss from the habitat of Qichun County, Hubei Province, China; and group B, moxa floss from the habitat of Nanyang County, Henan Province. Group C will use non-moxa floss for sham moxibustion as control. Patients will be treated for 20 min per session, for three sessions per week for 2 weeks, and followed up for 4 weeks. The primary outcome will be the change from baseline in the pain score of the Western Ontario and McMaster Osteoarthritis Index (WOMAC) at week 2. Secondary outcomes will include a change in the WOMAC pain score at week 6; the visual analogue scale for knee pain, the total WOMAC score, the WOMAC stiffness score, the WOMAC function score, the patient global assessment, and the responder criteria at weeks 2 and 6. Adverse events will be assessed throughout the study.DiscussionThis trial will help to identify the effectiveness of moxibustion for KOA and whether the habitat of moxa floss contributes to the effect of moxibustion.Trial registrationAcupuncture-Moxibustion Clinical Trial Registry: AMCTR-IOR-16000007. Registered on 29 February 2016.Electronic supplementary materialThe online version of this article (10.1186/s13063-018-2794-1) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Moxibustion using different habitat moxa floss for moderate to severe primary knee osteoarthritis: study protocol for a three-armed randomized, double-blinded, sham-controlled trial

Zhao

Kang

et al. 2018

Trials

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“…Moxibustion has been reported as a successful therapeutic in treating knee osteoarthritis [144]. Research shows that patients treated with moxibustion experience significantly improved pain, stiffness, and physical function compared with sham-moxibustion [145]. Although the majority of systematic reviews and meta-analyses of randomized controlled trials point to absences in the research and request further well-designed, largescale RCTs, the overall outcome points to positive effects in managing the symptoms of post-stroke urinary incontinence [146] and constipation [147], use as an adjuvant therapy for chronic kidney disease [148], and in treating diabetic peripheral neuropathy [149].…”

Section: Moxibustionmentioning

confidence: 99%

Understanding Traditional Chinese Medicine Therapeutics: An Overview of the Basics and Clinical Applications

et al. 2021

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Traditional Chinese medicine (TCM) is a systematic healthcare system developed from clinical experience based on a scientific model of regulation. TCM relies on unique theories and practices to treat diseases and enhance health. These practices include Chinese herbal medicine and dietetics, acupuncture and moxibustion, and other non-medication therapies such as Chinese bodywork or manual therapy, known as “Tuina”, and traditional biofeedback exercises, known as “Qigong” and “Taijiquan”. The integration of TCM in Western health systems and research requires a rational communicable theory, scientific proof of efficacy and safety, and quality control measures. Understanding the structural concepts of the TCM language makes possible the parallelism to Western physiology, and the inherent rational use of the reflex therapeutic systems, anti-inflammatory mechanisms and mental training involved, for example, in acupuncture and “Qigong”. The results of TCM clinical trials and fundamental research on its nature and mechanisms have encouraged the development and application of well-designed research strategies such as double blinding in acupucture to overcome limitations and resistances in integrating these practices into the existing biomedical paradigms of the West. This review aims to overview some TCM theoretical concepts and the evidence-based clinical application of TCM’s leading practices to create an easy-to-consult and condensed source of information, available for the healthcare community, facilitating the understanding and communication between conventional health professionals and TCM practitioners and acupuncturists.

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Repeated exposure to moxa-burning smoke: its acute and chronic toxicities in rats

Han

Liu

Liu³

et al. 2018

Journal of Traditional Chinese Medicine

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Preliminary clinical randomized controlled trial on knee osteoarthritis treated with moxibustion

Cited by 6 publications

References 9 publications

Moxibustion using different habitat moxa floss for moderate to severe primary knee osteoarthritis: study protocol for a three-armed randomized, double-blinded, sham-controlled trial

Moxibustion using different habitat moxa floss for moderate to severe primary knee osteoarthritis: study protocol for a three-armed randomized, double-blinded, sham-controlled trial

Understanding Traditional Chinese Medicine Therapeutics: An Overview of the Basics and Clinical Applications

Repeated exposure to moxa-burning smoke: its acute and chronic toxicities in rats

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