Preliminary pharmacokinetic study of ibuprofen enantiomers after administration of a new oral formulation (ibuprofen arginine) to healthy male volunteers

Comparison of the antinociceptive effects of ibuprofen arginate and ibuprofen in rat models of inflammatory and neuropathic pain

“…The L-arginine salt of ibuprofen (ibuprofen arginate) is a highly soluble salt that is formed by combining racemic ibuprofen with the amino acid L-arginine. L-Arginine renders ibuprofen more soluble in water, facilitating its rapid absorption by the gastric and enteric mucosa (Fornasini et al, 1997). Furthermore, as L-arginine reduces ibuprofen-induced oxidative stress it is thought to be less toxic in the gastrointestinal tract (Jimenez et al, 2004).…”

Rationale and conditions for the requirement of chiral bioanalytical methods in bioequivalence studies

“…In addition, according to the Biopharmaceutics Classification System (BCS) [9,10], ibuprofen is a highly soluble at neutral pH class II drug with complete oral absorption, but whose rate of absorption is highly dependent on formulation and manufacturing factors [11,12] or even on the interaction with antacids [13]. In other words, due to its low solubility at acidic pH, different formulations may show different in vivo dissolution rates, which lead to different rates of absorption [14]. For these reasons it was chosen as a model drug in a previous [3] and the present work.…”

New approaches of LC‐MS compatible method development on α1‐acid glycoprotein‐based stationary phase for resolution of enantiomers by HPLC

“…It was first introduced by Hermansson in 1983 1 for direct resolution of racemic drugs by HPLC under RP conditions. Since that time, this CSP has found extensive use in various application areas such as the determination of active chiral substances and their metabolites in biological media 2–23, the pharmacokinetic studies of chiral drugs 24–28 and the analysis of bioactive chiral compounds in plants 29. Resolution of enantiomers of various categories by CHIRAL‐AGP has been the subject of numerous pieces of work and has led to a certain number of validated methods for drug analysis 19–22, 30–34.…”