Preliminary Phytochemical Screening, Renal and Haematological Effects of Portulaca Oleracea (Whole Plant) in Swiss Albino Mice

Shafi, Sabeeha; Tabassum, Nahida

doi:10.7897/2230-8407.06672

Cited by 5 publications

(5 citation statements)

References 5 publications

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“…The use of Portulaca oleracea in folk medicine dates back to ancient times. It has been listed by the World Health Organization (WHO) as one of the most commonly used medicinal plants, which has given it the name, 'Global Panacea' [6]. All parts of the plant, especially the leaves and stems, are useful as remedies for many ailments and they are usually used in fresh or dried state.…”

Section: Introductionmentioning

confidence: 99%

Haematological profile of albino rats exposed to polar leaf extracts of Portulaca oleracea Linn.

Obinna

Delesi

Eriarie

et al. 2019

GSC Biol. and Pharm. Sci.

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Although the use of medicinal plants is becoming popular globally, some of these plants which are purported to be safe are not without side effects or toxicity. Portulaca oleracea, Linn. is among the medicinal plants used globally in the treatment of diseases and management of health challenges. The dearth of information on the toxicity of Portulaca oleracea in a long term use prompted this study which investigated the sub-chronic effect of the oral administration of polar (aqueous methanol) leaf extracts of Portulaca oleracea on haematological parameters in male albino rats. Sixtyfour animals were randomly divided into 4 groups of 16 rats each. Group 1(Control) received 0.5 ml of 20% Tween 80 (vehicle), Groups 2, 3 & 4 received 125, 250 & 500 mg/kg bw of the extract respectively for 60 days by oral gavage. On days 14, 28, 42 and 60; four rats from each group were anaesthetized and blood samples were collected for haematology. No significant (p>0.05) variation occurred in the mean values of PCV, hemoglobin concentration, RBC count, platelet count and differential leucocyte count relative to the control throughout the 60-day duration. Significant (p<0.05) increase in WBC count was recorded on day 42 in the 500mg treated group. Oral administration of polar leaf extract of P.oleracea as used in this study had no injurious effect on haematological parameters in a long term treatment of 60 days; thus can be said to be non-toxic to blood parameters.

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Section: Introductionmentioning

confidence: 99%

Haematological profile of albino rats exposed to polar leaf extracts of Portulaca oleracea Linn.

Obinna

Delesi

Eriarie

et al. 2019

GSC Biol. and Pharm. Sci.

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“…Acute toxicity evaluation gives the information about LD50. Both subacute and chronic evaluations give information about the cumulative toxicity at low dose on prolonged period of time 11 . With this view, in the present study, the extract was subjected to a toxicity study.…”

Section: Discussionmentioning

confidence: 99%

Chronic and Sub Acute Toxicity Study of the N-Butanol Extract of the Marine Sediment Fungus Aspergillus Protuberus Sp1

Mathan¹,

A²,

Daran³

et al. 2015

Int. Res. J. Pharm.

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This study was designed to evaluate the toxicity of the n-butanol extract of marine derived fungi Aspergillus protuberus sp1. Lethal dose (LD50), chronic and sub acute toxicities were determined in the rats. From the LD50, the effective dose (ED50) was determined. The n-butanol extract was prepared at the concentrations of 200, 400, and 600 mg.kg -1 body weight. In the sub acute toxicity study, the prepared extract was given orally to the experimental rats for fourteen days and in case of chronic toxicity study, it was given for ninety days. Then the animals were observed for the biochemical and hematological effects, macroscopic and microscopic changes in the liver and kidney. Results showed that, in both sub acute and chronic toxicity studies, the experimental rats showed normal general behavior, respiratory pattern, cardiovascular signs, motor activities, reflexes and normal change in skin and fur. The results also showed that the extract did not induce any biochemical, hematological effects, macroscopic and microscopic changes in the liver and kidney. Collectively, these data demonstrate that the extract is safe and these results are useful for further investigation of this fungus in the future.

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“…The authors indicate that Moringa oleifera leaf extract has no toxic effects when administered in concentrated doses over a short period [170][171][172]. Hydroalcoholic extract of Portulaca oleracea at the dose level of 500 mg/kg can be used for further pharmacological activity and at the dose level of 400mg/kg have significant hepato protection [173]. The toxicity of compounds (phenolics, terpenoids and alkaloids) of certain anti-fatigue plants was also evaluated.The flavonoid fraction of the leaves of the Anisomelles Indica Kuntze seems to be safe for oral administration and has been shown that it is non-toxic following acute exhibitions with mice under experience conditions where the maximum tolerated dose is assessed at more than 5000 mg / kg B.W [63,174].…”

Section: Toxicity Of Doping Molecules and Herbalmentioning

confidence: 99%

Phytochemical Contain, Biological Properties and Toxicities of Herbals Used for Doping

Traore,

Guenne,

Kobende

et al. 2024

Preprint

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Substances derived from herbals are much in demand in doping practices because of their interesting biological properties for physical exercise and sport. This review aimed to investigate anti-fatigue herbals, their properties, analysis methods and toxicity. Data indicate that phytomolecules have beneficial effects on the physiological and biochemical parameters of the body undergoing exercise. They reduce fatigue and promote recovery by improving antioxidant enzyme activities, immune responses, blood pressure, body composition and by reducing the accumulation of toxic metabolites and systemic inflammation. Thus, the use of herbal could provide relief to people who exert intense physical activities such as farmers and athletes; for this, these peoples must do careful, the use of doping herbal must be done in accordance with all the previsions which take into account the need for the use of herbal supplement, the doses. In addition, these benefits attributed to herbals should not conceal the drawbacks of using them in sport.Some phytomolecules are toxic when used in large quantities, and others, in this case alkaloids, should be avoided by athletes.

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Preliminary Phytochemical Screening, Renal and Haematological Effects of Portulaca Oleracea (Whole Plant) in Swiss Albino Mice

Cited by 5 publications

References 5 publications

Haematological profile of albino rats exposed to polar leaf extracts of Portulaca oleracea Linn.

Haematological profile of albino rats exposed to polar leaf extracts of Portulaca oleracea Linn.

Chronic and Sub Acute Toxicity Study of the N-Butanol Extract of the Marine Sediment Fungus Aspergillus Protuberus Sp1

Phytochemical Contain, Biological Properties and Toxicities of Herbals Used for Doping

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