Preliminary study of indirect CT lymphography-guided sentinel lymph node biopsy in a tongue VX2 carcinoma model

Wu, Haitao; Xu, Xiaoxing; Hui, Ying; Hoffman, Matthew R.; Shen, Na; Sha, Yan; Zhou, Lingyan

doi:10.1016/j.ijom.2009.07.009

Cited by 18 publications

(29 citation statements)

References 20 publications

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“…Non-met LN = non-metastatic lymph nodes; met = metastatic; FDD = filling defect diameter; IFD = intranodal filling defect enhancement or metastases in the parotid or submandibular lymph nodes of tumour-bearing rabbits. 16,17 In the present study, we confirmed that the lymph nodes enhanced during indirect CT lymphography were deep cervical lymph nodes, according to their position and size in CT lymphography images and their histopathological results. We found no enhancement or metastases in parotid or submandibular lymph nodes.…”

Section: Discussionsupporting

confidence: 83%

“…16,20 In enhanced lymph nodes showing filling defects, we also calculated the filling defect diameter and intranodal filling defect ratio (i.e. the ratio between the area of filling defect and the area of lymph node).…”

Section: Image Analysismentioning

confidence: 99%

“…9,10 Recently, indirect CT lymphography has been successfully employed to identify sentinel lymph nodes in the breast, oesophagus, lung, skin, and head and neck, using the non-ionic, iodinated, water-soluble contrast agent iopamidol. [12][13][14][15][16][17] To the best of our knowledge, iopamidol has not previously been used to differentiate metastatic from non-metastatic lymph nodes, or to analyse their characterisation on CT lymphography, either quantitatively or qualitatively.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of cervical lymph node metastases using indirect computed tomography lymphography with iopamidol in a tongue VX2 carcinoma model

Shu

Wang

et al. 2011

J. Laryngol. Otol.

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Section: Discussionsupporting

confidence: 83%

Section: Image Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of cervical lymph node metastases using indirect computed tomography lymphography with iopamidol in a tongue VX2 carcinoma model

Shu

Wang

et al. 2011

J. Laryngol. Otol.

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“…In 2008, Takahashi et al administered subcutaneous injections to the breast cancer patients and accurately detected the sentinel nodes with CT-LG with an identification rate of 96% and 92% with dye guided procedures [38]. These results were also supported by Wu et al [39]. …”

Section: Resultsmentioning

confidence: 88%

Current and Future Lymphatic Imaging Modalities for Tumor Staging

Murtaza

Gao

Liu

et al. 2014

BioMed Research International

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Tumor progression is supported by the lymphatic system which should be scanned efficiently for tumor staging as well as the enhanced therapeutic outcomes. Poor resolution and low sensitivity is a limitation of traditional lymphatic imaging modalities; thus new noninvasive approaches like nanocarriers, magnetic resonance imaging, positron-emission tomography, and quantum dots are advantageous. Some newer modalities, which are under development, and their potential uses will also be discussed in this review.

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“…The results obtained by Takahashi et al on the use of the combined method (CT-LG and dye-method) of identification of sentinel nodes in breast cancer are corroborated by a study conducted by Wu et al on the identification of sentinel lymph nodes in the tounge VX2 carcinoma model. [16] The main concern with the use of highly water soluble small organic iodinated molecules as CT contrast enhancers is they tend to suffer from very short imaging times due to rapid renal clearance and non-specific vascular permeation.…”

Section: Lymphatic Imagingmentioning

confidence: 99%

Advances in lymphatic imaging and drug delivery

Nune

Gunda

Majeti

et al. 2011

Advanced Drug Delivery Reviews

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Cancer remains the second leading cause of death after heart disease in the US. While metastasized cancers such as breast, prostate, and colon are incurable, before their distant spread, these diseases will have invaded the lymphatic system as a first step in their progression. Hence, proper evaluation of the disease state of the lymphatics which drain a tumor site is crucial to staging and the formation of a treatment plan. Current lymphatic imaging modalities with visible dyes and radionucleotide tracers offer limited sensitivity and poor resolution; however, newer tools using nanocarriers, quantum dots, and magnetic resonance imaging promise to vastly improve the staging of lymphatic spread without needless biopsies. Concurrent with the improvement of lymphatic imaging agents, has been the development of drug carriers that can localize chemotherapy to the lymphatic system, thus improving the treatment of localized disease while minimizing the exposure of healthy organs to cytotoxic drugs. This review will focus on the use of various nanoparticulate and polymeric systems that have been developed for imaging and drug delivery to the lymph system, how these new devices improve upon current technologies, and where further improvement is needed.

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Preliminary study of indirect CT lymphography-guided sentinel lymph node biopsy in a tongue VX2 carcinoma model

Cited by 18 publications

References 20 publications

Assessment of cervical lymph node metastases using indirect computed tomography lymphography with iopamidol in a tongue VX2 carcinoma model

Assessment of cervical lymph node metastases using indirect computed tomography lymphography with iopamidol in a tongue VX2 carcinoma model

Current and Future Lymphatic Imaging Modalities for Tumor Staging

Advances in lymphatic imaging and drug delivery

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