2011
DOI: 10.1210/jc.2011-0414
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Premature Ovarian Failure in Patients with Autoimmune Addison's Disease: Clinical, Genetic, and Immunological Evaluation

Abstract: This study indicates that AD is frequently associated with POF and that steroidogenic antibodies are markers of patients with POF. Steroidogenic autoantibodies are predictive markers of POF in patients with AD.

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Cited by 101 publications
(67 citation statements)
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“…Reato et al investigated the prevalence of POI in women with autoimmune AD (73). In this specific clinical setting they found POI in 41% of women with APS1 and 16% of women with APS2.…”
Section: Syndromic Poimentioning
confidence: 99%
“…Reato et al investigated the prevalence of POI in women with autoimmune AD (73). In this specific clinical setting they found POI in 41% of women with APS1 and 16% of women with APS2.…”
Section: Syndromic Poimentioning
confidence: 99%
“…В нашем исследовании связь между присутствием антител к NALP5 и гипогонадизмом у женщин обнаружить не удалось. В развитии синдрома преждевременного истощения яичников более важную роль играют, по-видимому, антитела к SCC (фермент, отщепля-ющий боковую цепь холестерина) [13].…”
Section: Discussionunclassified
“…The endocrine combinations are type 1 (or autoimmune polyendocrinopahy -candidiasis -ectodermal dystrophy) and type 2 autoimmune polyglandular syndrome [8,14] . Addison's disease associated POF is presented in 10% of cases and POF correlates autoimmune adrenalitis in 2-20% of situations because both ovaries and adrenals expose common antigens with steroid-producing cell antibodies and steroidogenic enzymes antibodies (as 17ᾳ-hydroxylase autoantibodies or P450 side-chain cleavage enzyme autoantibodies) [9,15] . Autoimmune adrenal oophoritis involves a selective destruction of the theca cells with a specific preservation of granulosa cells (that produce low amount of estradiol) [9,15,16] .…”
Section: Editorialmentioning
confidence: 99%
“…Addison's disease associated POF is presented in 10% of cases and POF correlates autoimmune adrenalitis in 2-20% of situations because both ovaries and adrenals expose common antigens with steroid-producing cell antibodies and steroidogenic enzymes antibodies (as 17ᾳ-hydroxylase autoantibodies or P450 side-chain cleavage enzyme autoantibodies) [9,15] . Autoimmune adrenal oophoritis involves a selective destruction of the theca cells with a specific preservation of granulosa cells (that produce low amount of estradiol) [9,15,16] . The markers of ovarian reserve are high serum inhibin B (compared to healthy fertile women and other forms of immune oophoritis) and normal serum AMH (anti-mullerian hormone) in 2/3 of cases indicating a preserved pool of functioning follicles [9,15,16] .…”
Section: Editorialmentioning
confidence: 99%