Premature Ovarian Failure of Autoimmune Causes

Cârșote, Mara; Valea, Ana; Internationals, Ommega

doi:10.15436/2380-5595.15.364

Cited by 1 publication

(3 citation statements)

References 16 publications

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“…[82][83][84][85][86] Exact mechanism of autoimmune POI remains obscure and may be due to genetic and or environmental factors that are responsible for initiating immune response. 43,75,83,87,88 Important factors involved are: Major histocompatibility complex antigen (HLA), cytokines, cell-mediated immunity, antibodymediated immunity, etc. 43,75,83,87,88 There are three main types of autoimmune POI: Adrenal autoimmune POI, non-adrenal autoimmune POI and isolated idiopathic POI.…”

Section: Autoimmune Factorsmentioning

confidence: 99%

“…43,75,83,87,88 Important factors involved are: Major histocompatibility complex antigen (HLA), cytokines, cell-mediated immunity, antibodymediated immunity, etc. 43,75,83,87,88 There are three main types of autoimmune POI: Adrenal autoimmune POI, non-adrenal autoimmune POI and isolated idiopathic POI. 43,88,89 Autoimmune causes in pathogenesis of POI is characterised by presence of autoantibodies directed towards the ovarian tissue.…”

Section: Autoimmune Factorsmentioning

confidence: 99%

“…43,75,83,87,88 There are three main types of autoimmune POI: Adrenal autoimmune POI, non-adrenal autoimmune POI and isolated idiopathic POI. 43,88,89 Autoimmune causes in pathogenesis of POI is characterised by presence of autoantibodies directed towards the ovarian tissue. 84,90,91 These AOAs can be detected in the serum of affected females before clinical onset of POI.…”

Section: Autoimmune Factorsmentioning

confidence: 99%

See 2 more Smart Citations

Premature Ovarian Insufficiency: Aetiology and Long-Term Consequences

Kumar¹,

Manesh²

2017

Women Health Open J

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Premature ovarian insufficiency (POI) is characterised by premature cessation of ovulation/ menstruation for 4-6 months along with raised serum gonadotropin levels especially follicle stimulating hormone (FSH) (>40 IU/L) on two or more occasions >4 weeks apart. POI is a heterogeneous disorder resulting from various autoimmune, iatrogenic and metabolic factors, chromosomal or genetic mutations and infections. Premature loss of ovarian function in women with POI is associated with long-term psychosocial sequelae, infertility and major health complications. It is also associated with age-specific increase in mortality due to cardio-vascular diseases. Its occurrence has increased in recent years as more and more women now-a-days attain motherhood late, also there is increase in incidence of gynaecological malignancies and its successful management leading to increased risk of POI. This manuscript aims to highlight the recent advances in pathogenesis and management of POI. Literature regarding premature ovarian insufficiency, its incidence, pathogenesis, management and recent advances was searched from various English language journals, WHO, ACOG data, published peer-reviewed articles on PubMed, Medline, Embase and Google Scholar upto 2017.

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