Prenatal and childhood phthalate exposure and attention deficit hyperactivity disorder traits in child temperament: A 12-year follow-up birth cohort study

Ku, Hsiu-Ying; Tsai, Tsung-Neng; Wang, Pei-Ling; Su, Pen‐Hua; Sun, Chien-Wen; Wang, Chien-Jen; Wang, Shuli

doi:10.1016/j.scitotenv.2019.134053

Cited by 38 publications

(18 citation statements)

References 35 publications

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“…Hyperactivity and working memory impairment are two significant symptoms in ADHD children [11]. Early-life phthalate exposure is related to the behavioral characteristics of ADHD in humans [9,10]. However, the mechanisms underlying the effects of DEHP exposure on symptoms of ADHD in the experimental animals have never been investigated.…”

Section: Discussionmentioning

confidence: 99%

“…In school-age children, behavioral problems such as emotional problems, aggression, hyperactivity, inattention, and working memory deficit are associated with prenatal DEHP exposure [6][7][8]. The outcome of DEHP-associated behaviors has led many researchers to notice the overlap with symptoms of attention-deficit hyperactivity disorder (ADHD) [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Recovery of BDNF and CB1R in the Prefrontal Cortex Underlying Improvement of Working Memory in Prenatal DEHP-Exposed Male Rats after Aerobic Exercise

Wang

Lin

Lee

et al. 2020

IJMS

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Early-life exposure to di-(2-ethylhexyl)-phthalate (DEHP) has been suggested to relate to hyperactivity, lack of attention, and working memory deficits in school-age children. Brain-derived neurotrophic factor (BDNF) and endocannabinoids are induced by aerobic exercises to provide beneficial effects on brain functions. This study investigated the mechanisms underlying working memory impairment and the protective role of exercise in prenatal DEHP-exposed male rats. Sprague Dawley dams were fed with vehicle or DEHP during gestation. The male offspring were trained to exercise on a treadmill for 5 weeks, which was followed by an assessment of their working memory with a T-maze delayed non-match-to-sample task. The expressions of BDNF, dopamine D1 receptor (D1R), cannabinoid receptor 1 (CB1R), and fatty acid amide hydrolase (FAAH) in the prefrontal cortex were detected by Western blot. The results showed that DEHP-exposed rats exhibited working memory impairments without significant alterations in locomotor activities. The reduced expressions of prefrontal BDNF and CB1R were obtained in the DEHP-exposed rats, while D1R and FAAH were barely affected. Importantly, aerobic exercise during childhood-adolescence prevented the impairment of working memory in the DEHP-exposed rats by recovering the BDNF and CB1R expressions in the prefrontal cortex. These findings suggest that exercise may provide beneficial effects in ameliorating the impairment of working memory in the prenatal DEHP-exposed male rats at late adolescence.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recovery of BDNF and CB1R in the Prefrontal Cortex Underlying Improvement of Working Memory in Prenatal DEHP-Exposed Male Rats after Aerobic Exercise

Wang

Lin

Lee

et al. 2020

IJMS

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“…Phthalate metabolite concentrations were higher in the 2- and 5-years old children, compared to 11 years old ones. Postnatal high exposure to phthalic acid ester is related to attention deficit hyperactivity disorder symptoms in children[ 207 ], and particularly diethylphthalate are inducing gut dysbiosis and consistent weight loss. One of the mechanisms proposed was through the aryl hydrocarbon receptor activation[ 208 ].…”

Section: Role Of Food Contaminants On Infant and Child Development Anmentioning

confidence: 99%

Early exposure to food contaminants reshapes maturation of the human brain-gut-microbiota axis

Sarron¹,

Pérot²,

Barbezier³

et al. 2020

WJG

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Early childhood growth and development is conditioned by the consecutive events belonging to perinatal programming. This critical window of life will be very sensitive to any event altering programming of the main body functions. Programming of gut function, which is starting right after conception, relates to a very well-established series of cellular and molecular events associating all types of cells present in this organ, including neurons, endocrine and immune cells. At birth, this machinery continues to settle with the establishment of extra connection between enteric and other systemic systems and is partially under the control of gut microbiota activity, itself being under the densification and the diversification of microorganisms’ population. As thus, any environmental factor interfering on this pre-established program may have a strong incidence on body functions. For all these reasons, pregnant women, fetuses and infants will be particularly susceptible to environmental factors and especially food contaminants. In this review, we will summarize the actual understanding of the consequences of repeated low-level exposure to major food contaminants on gut homeostasis settlement and on brain/gut axis communication considering the pivotal role played by the gut microbiota during the fetal and postnatal stages and the presumed consequences of these food toxicants on the individuals especially in relation with the risks of developing later in life non-communicable chronic diseases.

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“…Such widespread phthalate plasticizers (especially di‐alkyl phthalates) have been known to show reproductive toxicity, carcinogenic property, and mutagenic toxicity. Thus, many laboratories over the world have been involved in the study of such toxicities, especially in the study of symptoms and influences observed from children and pregnant women …”

Section: The Cartridge‐to‐cartridge Reproducibility Based On Four Spementioning

confidence: 99%

“…Thus, many laboratories over the world have been involved in the study of such toxicities, especially in the study of symptoms and influences observed from children and pregnant women. [1][2][3][4][5][6][7] A serious impact was also imposed on the Korean society on account of the events related to phthalates. For example, phthalates ingredients were found in imported and national cosmetics by the investigation of a civil organization in April 2003.…”

mentioning

confidence: 99%

Development of a New Solid Phase Extraction Cartridge Filled with Organic Monolith Particles for Extraction of di‐Alkyl Phthalates

Kim

Cheong

2019

Bulletin Korean Chem Soc

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Prenatal and childhood phthalate exposure and attention deficit hyperactivity disorder traits in child temperament: A 12-year follow-up birth cohort study

Cited by 38 publications

References 35 publications

Recovery of BDNF and CB1R in the Prefrontal Cortex Underlying Improvement of Working Memory in Prenatal DEHP-Exposed Male Rats after Aerobic Exercise

Recovery of BDNF and CB1R in the Prefrontal Cortex Underlying Improvement of Working Memory in Prenatal DEHP-Exposed Male Rats after Aerobic Exercise

Early exposure to food contaminants reshapes maturation of the human brain-gut-microbiota axis

Development of a New Solid Phase Extraction Cartridge Filled with Organic Monolith Particles for Extraction of di‐Alkyl Phthalates

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