Prenatal depression effects on neonates

Lundy, Brenda L; Jones, Nancy Aaron; Field, Tiffany; Nearing, Graciela; Davalos, Marisabel; Pietro, Paul A.; Schanberg, Saul M.; Kuhn, Catherine M.

doi:10.1016/s0163-6383(99)80009-5

Cited by 290 publications

(208 citation statements)

References 27 publications

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“…An organic difficulty in learning and/or performance on the habituation tasks is one explanation for unreliable discrimination performance at 6 mo. Newborns of depressed mothers show inferior performance on the Brazelton assessment (40,41), with lower orientation scores, abnormal reflexes, inferior excitability, and withdrawal scores (42). However, the successful discrimination at 10 mo by infants born to depressed mothers not treated with an SRI may be better explained by a delayed critical period trajectory caused by early stimulus deprivation.…”

Section: Discussionmentioning

confidence: 97%

Prenatal exposure to antidepressants and depressed maternal mood alter trajectory of infant speech perception

Weikum

Oberlander

Hensch

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

172

107

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Language acquisition reflects a complex interplay between biology and early experience. Psychotropic medication exposure has been shown to alter neural plasticity and shift sensitive periods in perceptual development. Notably, serotonin reuptake inhibitors (SRIs) are antidepressant agents increasingly prescribed to manage antenatal mood disorders, and depressed maternal mood per se during pregnancy impacts infant behavior, also raising concerns about long-term consequences following such developmental exposure. We studied whether infants' language development is altered by prenatal exposure to SRIs and whether such effects differ from exposure to maternal mood disturbances. Infants from non-SRI-treated mothers with little or no depression (control), depressed but non-SRI-treated (depressed-only), and depressed and treated with an SRI (SRI-exposed) were studied at 36 wk gestation (while still in utero) on a consonant and vowel discrimination task and at 6 and 10 mo of age on a nonnative speech and visual language discrimination task. Whereas the control infants responded as expected (success at 6 mo and failure at 10 mo) the SRI-exposed infants failed to discriminate the language differences at either age and the depressed-only infants succeeded at 10 mo instead of 6 mo. Fetuses at 36 wk gestation in the control condition performed as expected, with a response on vowel but not consonant discrimination, whereas the SRI-exposed fetuses showed accelerated perceptual development by discriminating both vowels and consonants. Thus, prenatal depressed maternal mood and SRI exposure were found to shift developmental milestones bidirectionally on infant speech perception tasks.L anguage, our most quintessential human characteristic, involves a complex interplay between biology and experience. At birth, infants possess an initial preparedness for language and a developmental readiness that supports learning any of the world's languages (1-3), yet also already show privileged processing to the native language from prenatal listening experience (4-6). During the following weeks and months of life, infants become progressively attuned to the properties of their native language, including its rhythmical and segmental (e.g., consonant) information (reviewed in refs. 7 and 8). The high degree of regularity in the timing of sequential tuning to properties of the native language suggests a series of critical or sensitive periods, i.e., points in development when the system is maximally influenced by input.The timing of onset of these sensitive periods seems to be maturationally constrained. Infants born 3 mo preterm attune to the phonetic properties (9) of their native language at the same gestational age as full-term infants, not according to the number of months of postnatal listening experience. Such maturational constraints can protect development: ensuring the optimal consecutive stabilization of the perceptual components that contribute in a step-wise fashion to language acquisition (10). However, it is known from research i...

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Section: Discussionmentioning

confidence: 97%

Prenatal exposure to antidepressants and depressed maternal mood alter trajectory of infant speech perception

Weikum

Oberlander

Hensch

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

172

107

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“…Even though infants of depressed mothers exhibit a profile of behavioral and physiological dysregulation as early as birth Jones, Field, Fox, et al, 1997;Lundy et al, 1999), infants of depressed mothers with distinct interaction styles develop distinct neurobehavioral profiles. Depressed mothers show two distinct maternal behavior patterns when interacting with their infants (Cohn, Matias, Tronick, Connell, & Lyons-Ruth, 1986; Tronick & Field, 1986).…”

Section: Eeg Asymmetry; Depression; Interaction Stylementioning

confidence: 99%

“…Furthermore, there is evidence to indicate that infants reared in deprived environments develop distinct brain electrical activity patterns including EEG asymmetries (Marshall, Fox, & BEIP, 2004) and decreased brain glucose metabolism across several of the cortical and limbic areas involved in affect regulation (Chugani et al, 2001). Even though infants of depressed mothers exhibit a profile of behavioral and physiological dysregulation as early as birth Jones, Field, Fox, et al, 1997;Lundy et al, 1999), infants of depressed mothers with distinct interaction styles develop distinct neurobehavioral profiles. Depressed mothers show two distinct maternal behavior patterns when interacting with their infants (Cohn, Matias, Tronick, Connell, & Lyons-Ruth, 1986; Tronick & Field, 1986).…”

mentioning

confidence: 99%

Withdrawn and intrusive maternal interaction style and infant frontal EEG asymmetry shifts in infants of depressed and non-depressed mothers

Diego

Field

Jones

et al. 2006

Infant Behavior and Development

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The effects of maternal interaction style (intrusive/withdrawn) on the development of brain electrical activity were studied in infants of depressed and non-depressed mothers shortly after birth and again at 3-6 months of age. Infants of depressed mothers exhibited significantly greater relative right frontal EEG activation than infants of non-depressed mothers. Infants of depressed withdrawn mothers exhibited greater relative right frontal EEG activation than infants of depressed intrusive mothers. Furthermore, while infants of depressed mothers with intrusive interaction styles showed a shift towards greater relative left frontal EEG activation from birth to 3-6 months, infants of depressed mothers with withdrawn interaction styles showed a shift towards greater relative right frontal EEG activation. Keywords EEG asymmetry; Depression; Interaction styleMaternal depression has negative effects on infant behavior and physiology. For example, newborns of depressed mothers are more irritable, less consolable (Whiffen & Gotlib, 1989;Zuckerman, Als, Bauchner, Parker, & Cabral, 1990) and less responsive to stimulation (Abrams, Field, Scafidi, & Prodromidis, 1996). Infants of depressed mothers are also less responsive to facial expressions and show more negative and less positive affect when interacting with both their mothers (Cohn, Campbell, Matias, & Hopkins, 1990;Field, 1984) and a non-distressed adult (Field et al., 1988). In addition, infants of depressed mothers exhibit a distinct physiological profile marked by greater relative right frontal EEG activation (Dawson, Klinger, Panagiotides, Hill, & Spieker, 1992;Dawson et al., 1999;Field, Pickens, Fox, & Gonzalez, 1996;Jones, Field, Fox, Lundy, & Davalos, 1997).Asymmetries in brain electrical activity (EEG) over the frontal cortex are associated with the balance of the neural activity underlying two essential dimensions of affect regulation including behavioral approach and behavioral withdrawal (Davidson, 1996 andFox, 1994). Greater relative right frontal EEG activation is thought to reflect greater behavioral withdrawal and has been associated with responses to negative stimuli, inhibited behavior, negative affect and poor emotion regulation (Davidson, 1996 andFox, 1994). Infants also exhibit greater relative right frontal EEG activation during the expression, regulation and perception of negative/ withdrawal emotions (Davidson & Fox, 1982;Field, Pickens, Fox, Gonzalez, & Nawrocki, 1998 activation has been consistently noted in depressed adults (see Davidson, 1996 andDavidson, 2000 for reviews) and infants of depressed mothers as early as birth and Jones et al., 1998.Frontal EEG asymmetry profiles in depressed individuals have been shown to remain stable across time (Tomarken, Keener, & Neubauer, 1994; Vuga et al., 2006) and are present even when these individuals show a remission in their behavioral symptoms (Henriques & Davidson, 1990). Frontal EEG asymmetry profiles have also been shown to remain stable from 1 month to 3 months (Jones, Field, Fox, ...

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“…Prenatal maternal depression is noted to negatively affect fetal activity (increased) and fetal growth (decreased) and neonatal outcome (greater incidence of prematurity and low birthweight) in different cultures (Field, Diego, Dieter, et al 2004;Lundy, et al 1999;Zuckerman, Bauchner, Parker, & Cabral, 1990). Many fathers are also depressed.…”

Section: Prenatal Paternal Depressionmentioning

confidence: 99%

Prenatal paternal depression

Field

Diego

Hernandez‐Reif

et al. 2006

Infant Behavior and Development

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Prenatal depressive symptoms, anxiety, anger and daily hassles were investigated in 156 depressed and non-depressed pregnant women and their depressed and non-depressed partners (fathers-to-be). Depressed versus non-depressed fathers had higher depression, anxiety and daily hassles scores. Although the pregnant women in general had lower anxiety, anger and daily hassles scores than the men, the scores on the measures for depressed fathers and depressed mothers did not differ. Paternal depression appeared to have less effect than maternal depression on their partners' scores. However, the similarity between the scores of depressed mothers and depressed fathers highlights the importance of screening for depression in fathers-to-be as well as mothers-to-be as well as during pregnancy. Prenatal Paternal DepressionPrenatal maternal depression is noted to negatively affect fetal activity (increased) and fetal growth (decreased) and neonatal outcome (greater incidence of prematurity and low birthweight) in different cultures (Field, Diego, Dieter, et al 2004;Lundy, et al 1999;Zuckerman, Bauchner, Parker, & Cabral, 1990). Many fathers are also depressed. In an Australian study, for example, 20% of mothers and 12% of fathers were significantly distressed at mid-pregnancy (Morse, Buist, & Durkin, 2000). In a Norwegian study, psychological distress was reported by 37% of the mothers and 13% of the fathers a few days after childbirth, and severe distress symptoms were reported by 9% and 2% of the mothers and fathers, respectively (Skari, et al 2002). In an American study (Goodman, 2004), the incidence of paternal depression ranged from 1% to 26% in community samples, and from 24% to 50% among partners of women experiencing depression. In at least one study, prenatal paternal and maternal depressed mood were significant predictor variables for the postnatal moods of both mothers and fathers (Matthey, Barnett, Ungerer, Waters, 2000). The negative effects of paternal depression on early interactions between fathers and infants and on child development have been documented if prenatal paternal depression is predictive of postnatal paternal depression, it would be important to identify depressed fathers prenatally for early intervention to help prevent postnatal paternal depression and its negative effects. Paternal depression during the postnatal period has been associated with adverse emotional and behavioral problems in preschool children after controlling postnatal for maternal depression (Ramchandari, Stein, Evans, O'Connor, 2005). In addition, depression in the father-to-be might be expected to negatively affect the mother's mood state during pregnancy and thereby have indirect negative effects on fetal development and neonatal outcome.The present study investigated prenatal depression and other mood states in both depressed and non-depressed pregnant women and their depressed and non-depressed partners (fathersto-be). Comparisons were made between the prenatal mood states of 1) depressed versus nondepressed fathe...

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Prenatal depression effects on neonates

Cited by 290 publications

References 27 publications

Prenatal exposure to antidepressants and depressed maternal mood alter trajectory of infant speech perception

Prenatal exposure to antidepressants and depressed maternal mood alter trajectory of infant speech perception

Withdrawn and intrusive maternal interaction style and infant frontal EEG asymmetry shifts in infants of depressed and non-depressed mothers

Prenatal paternal depression

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