Prenatal Diagnosis of Open Spina Bifida in Emilia-Romagna

Ghi, T.; Cocchi, Guido; Conti, Letizia; Pacella, G.; Youssef, A.; Rizzo, Nicola; Pilu, Gianluigi

doi:10.1159/000366158

Cited by 5 publications

(8 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In Denmark, 88.5% of the total population of SB was diagnosed before gestational week 22 and 93.9% at any gestational age. The EUROCAT society and other studies report prenatal detection rates in the range 81–90% [ 4 , 8 , 9 , 24 , 25 ]. Our overall prenatal detection rate was significantly higher than the percentage (89.3%) reported by the EUROCAT ( p = 0.03), suggesting that the Danish prenatal screening program outperforms those of other European countries that pursue different strategies for prenatal screening for anomalies.…”

Section: Discussionmentioning

confidence: 99%

“…Among all Danish SB cases, 81.6% resulted in ToP, and of those diagnosed with ultrasound before gestational week 22, 90.3% opted for termination. The ToP rate following prenatal diagnosis was in the same range as for Alsace in France (97%) [ 4 ] and the region Emilia-Romagna in Italy (92.4%) [ 8 ] (only open SB), but higher than rates reported by the EUROCAT (66%) [ 26 ], Atlanta in the US (34%) [ 12 ], and the northern parts of the Netherlands (78.6% when diagnosed in the second trimester) [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ultrasound in Prenatal Diagnostics and Its Impact on the Epidemiology of Spina Bifida in a National Cohort from Denmark with a Comparison to Sweden

Bodin

Rasmussen

Tabor

et al. 2018

BioMed Research International

View full text Add to dashboard Cite

Objectives The aim of this study was to assess the incidence, the prenatal detection rate by ultrasound, and the pregnancy outcome of spina bifida (SB) in Denmark (DK) in 2008–2015 and to compare results to national data from Sweden. Methods Data were retrieved from the Danish Fetal Medicine Database, which includes International Classification of Diseases- (ICD-) 10 codes for pre- or postnatally diagnoses and pregnancy outcome. Missing data were obtained from the National Patient Register. Livebirth data with myelomeningocele (MMC) in Sweden were obtained from different databases. Results There were 234 cases with SB in DK in 2008–2015. The incidence of SB was 4.9 : 10,000; 89% were detected with ultrasound prior to week 22; 90% of these pregnancies were terminated (ToP); 91% were isolated malformations of which 11% showed abnormal karyotype. The incidence of newborns with MMC was 1.3 : 10,000 in Sweden. Conclusions Ultrasound screening has a major impact on the epidemiology of SB. The prenatal detection rate of SB was high, and most SB cases were isolated and had a normal karyotype. Among women with a prenatal fetal diagnosis of SB, 90% chose to have ToP. The incidence of newborns with SB was higher in Sweden than in DK.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ultrasound in Prenatal Diagnostics and Its Impact on the Epidemiology of Spina Bifida in a National Cohort from Denmark with a Comparison to Sweden

Bodin

Rasmussen

Tabor

et al. 2018

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Ghi et al reviewed the prenatal detection rate for open spina bifida in the Emilia-Romagna region between 2001 and 2011. The overall detection was about 80% and the diagnosis was made prior to 23 weeks in only 73% of the cases [17]. However, in a retrospective evaluation of 627 fetuses, Bahlmann et al found a high association between posterior fossa abnormalities and open spine defects at 18-22 weeks' gestation [5].…”

Section: Discussionmentioning

confidence: 99%

Fetal profile in fetuses with open spina bifida

Prodan

Hoopmann

Sonek

et al. 2020

Arch Gynecol Obstet

View full text Add to dashboard Cite

Objective To determine whether the frontomaxillary facial (FMF) angle and the prefrontal space ratio (PFSR) are helpful in screening for open spinal defects by ultrasound in the second and third trimesters of pregnancy. Methods The FMF angle and the PFSR were measured in fetuses with spina bifida according to standardized protocols. The normal range of the PFSR was previously published by our group. To determine the normal values for the FMF angle in the second and third trimesters of pregnancy, we used the same stored images from the above-mentioned study. Results 71 affected and 279 normal fetuses were included in this study. Median gestational ages in the two groups were 21.1 weeks and 21.6 weeks, respectively. In fetuses with spina bifida, the FMF angle was significantly smaller than in the normal population (72.9° versus 79.6°). However, the measurement was below the fifth centile in only 22.5% of the affected fetuses. The PFSR was similar in both groups. Conclusions The FMF angle is smaller in second and third trimester fetuses with open spina bifida. However, the difference is not large enough to implement this marker in current screening programs.

show abstract

“…5 In humans, the prevalence of SBA is 3.2 per 10,000 live births. 14 The aetiology of SBA in humans currently remains unclear, but may be related to various factors including maternal nutrition, environment and genetics. For example, folic acid supplementation during pregnancy prevents spina bifida.…”

Section: Discussionmentioning

confidence: 99%

Tethered cord syndrome with spina bifida aperta in cats: two case reports of different types

Tamura

Oji²,

Une³

et al. 2017

Journal of Feline Medicine and Surgery Open Reports

View full text Add to dashboard Cite

Case summaryTwo castrated male cats, aged 8 months old (case 1) and 10 months old (case 2), showed a history of progressive paraparesis, an over-reaching pelvic limb gait, urinary incontinence and a palpable dermoid fistula. In case 1, the fistula was connected to the dural sac on the conus medullaris, and the tethered spinal cord was retracted caudally. In case 2, the tubular structure was connected to the dural sac on the thoracic spinal cord, and the tethered spinal cord was retracted dorsally. Tethered cord syndrome secondary to spina bifida aperta was suspected in both cats. Excision of the fistula and release of the tethered spinal cord was performed. A histopathological examination confirmed the diagnosis of a meningomyelocele in case 1 and a meningocele in case 2. Paraparesis improved postoperatively in both cats. However, urinary incontinence in case 1 remained partially unresolved.Relevance and novel informationThis is the first report to describe the imaging characteristics, surgical treatments and outcomes of two different types of tethered cord syndrome with spina bifida aperta in cats. Tethered cord syndrome with spina bifida aperta needs to be included in the differential diagnosis of slowly progressive paraparesis in younger cats with or without vesicorectal failure and a palpable dermoid fistula.

show abstract

Prenatal Diagnosis of Open Spina Bifida in Emilia-Romagna

Cited by 5 publications

References 27 publications

Ultrasound in Prenatal Diagnostics and Its Impact on the Epidemiology of Spina Bifida in a National Cohort from Denmark with a Comparison to Sweden

Ultrasound in Prenatal Diagnostics and Its Impact on the Epidemiology of Spina Bifida in a National Cohort from Denmark with a Comparison to Sweden

Fetal profile in fetuses with open spina bifida

Tethered cord syndrome with spina bifida aperta in cats: two case reports of different types

Contact Info

Product

Resources

About