Prenatal exposure to lead in relation to risk of preterm low birth weight: A matched case–control study in China

Zhang, Bin; Xia, Wei; Li, Yuanyuan; Bassig, Bryan A.; Zhou, Aifen; Wang, Youjie; Li, Zhengkuan; Yao, Yuanxiang; Hu, Jie; Du, Xiaofu; Zhou, Yanqiu; Liu, Juan; Xue, Weiyan; Ma, Yue; Pan, Xinyun; Yang, Peng; Zheng, Tongzhang; Xu, Shunqing

doi:10.1016/j.reprotox.2015.06.051

Cited by 53 publications

(36 citation statements)

References 38 publications

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“…First, a study investigated the association between prenatal exposure to lead and the risk of low birth weight. The association was significant among female infants, but not in male infants 26 . As we know, low birth weight is a risk factor for higher BMI and obesity in adulthood 27 .…”

Section: Discussionmentioning

confidence: 69%

Blood lead level and its association with body mass index and obesity in China - Results from SPECT-China study

Wang

Chen

Nie

et al. 2015

Sci Rep

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We aimed to report environmental and blood lead level (BLL) in China, and investigate the relationship of BLL with body mass index (BMI) and obesity. 5558 subjects were enrolled from 16 sites in China. BLL was measured by atomic absorption spectrometry. Obesity was defined as BMI ≥ 30 kg/m2. Median (interquartile range) of BLL was 44.00 μg/L (29.00–62.16) for men and 37.79 μg/L (25.13–54.35) for women, about twice higher than in U.S. population. Subjects in rural and high-economic-status areas had significantly greater BLL (P < 0.001). However, in these areas, the lead levels in drinking water, river water and rice were comparable to or significantly lower than those in urban and low-economic-status areas. After adjustment for age, urbanization, economic status and metabolic factors, BLL was independently associated with BMI in women (P for trend < 0.001), but not in men. In fully adjusted model, increased quartiles of BLL were associated with significantly increased odds ratios of obesity (P for trend < 0.01) in women. In conclusion, BLLs in Chinese adults were much higher than in developed countries. There was a sex-specific association between BLL and BMI. Elevated BLL does not appear to be associated with lead levels in drinking water or rice, suggesting some other exposure source.

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Section: Discussionmentioning

confidence: 69%

Blood lead level and its association with body mass index and obesity in China - Results from SPECT-China study

Wang

Chen

Nie

et al. 2015

Sci Rep

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“…Lead has been shown to be associated with increased risk of PTB 36. A recent case-control study (n=102 preterm cases and 306 term controls), also in China, found that infants in the highest tertile of lead levels, versus the lowest, had higher odds of being born preterm (adjusted OR 2.96, CI 1.49 to 5.87) 37…”

Section: Macroenvironmental Factors That May Help To Explain Racial Dmentioning

confidence: 99%

Racial disparities in preterm birth in USA: a biosensor of physical and social environmental exposures

et al. 2019

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“…Lead also binds to sulfhydryl groups and inhibits enzymes involved in heme synthesis, which is important for cellular respiration and metabolism, as well as hemoglobin synthesis (Flora et al 2012). Several epidemiological studies have shown inconsistent associations of prenatal lead exposure and fetal growth (Burris et al 2011; Cantonwine et al 2010; Gonzalez-Cossio et al 1997; Jelliffe-Pawlowski et al 2006; Nishioka et al 2014; Wigle et al 2007; Zhang et al 2015; Zhu et al 2010). These studies used traditional regression methods, also known as ordinary least squares (OLS) regression, to estimate the conditional mean response of the association between prenatal lead exposure and fetal growth.…”

Section: Introductionmentioning

confidence: 99%

Prenatal lead exposure and fetal growth: Smaller infants have heightened susceptibility

Rodosthenous

Burris²,

Svensson

et al. 2017

Environment International

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Background As population lead levels decrease, the toxic effects of lead may be distributed to more sensitive populations, such as infants with poor fetal growth. Objectives To determine the association of prenatal lead exposure and fetal growth; and to evaluate whether infants with poor fetal growth are more susceptible to lead toxicity than those with normal fetal growth. Methods We examined the association of second trimester maternal blood lead levels (BLL) with birthweight-for-gestational age (BWGA) z-score in 944 mother-infant participants of the PROGRESS cohort. We determined the association between maternal BLL and BWGA z-score by using both linear and quantile regression. We estimated odds ratios for small-for-gestational age (SGA) infants between maternal BLL quartiles using logistic regression. Maternal age, body mass index, socioeconomic status, parity, household smoking exposure, hemoglobin levels, and infant sex were included as confounders. Results While linear regression showed a negative association between maternal BLL and BWGA z-score (β=−0.06 z-score units per log2 BLL increase; 95% CI: −0.13, 0.003; P=0.06), quantile regression revealed larger magnitudes of this association in the <30th percentiles of BWGA z-score (β range [−0.08, −0.13] z-score units per log2 BLL increase; all P values <0.05). Mothers in the highest BLL quartile had an odds ratio of 1.62 (95% CI: 0.99–2.65) for having a SGA infant compared to the lowest BLL quartile. Conclusions While both linear and quantile regression showed a negative association between prenatal lead exposure and birthweight, quantile regression revealed that smaller infants may represent a more susceptible subpopulation.

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Prenatal exposure to lead in relation to risk of preterm low birth weight: A matched case–control study in China

Cited by 53 publications

References 38 publications

Blood lead level and its association with body mass index and obesity in China - Results from SPECT-China study

Blood lead level and its association with body mass index and obesity in China - Results from SPECT-China study

Racial disparities in preterm birth in USA: a biosensor of physical and social environmental exposures

Prenatal lead exposure and fetal growth: Smaller infants have heightened susceptibility

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