Prenatal Exposure to Organophosphate Pesticides and Neurobehavioral Development of Neonates: A Birth Cohort Study in Shenyang, China

Zhang, Ying; Han, Sung‐Sik; Liang, Dan; Shi, Xi; Wang, Fengzhi; Liu, Wei; Zhang, Li; Chen, Lixin; Gu, Yingzi; Tian, Ying

doi:10.1371/journal.pone.0088491

Cited by 76 publications

(77 citation statements)

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“…The DAP metabolite concentrations measured in our study however, were considerably lower compared to the levels observed in China and Taiwan (Huang et al, 2017; Liu et al, 2016; Zhang et al, 2014). This may be explained by China’s heavy use of OP pesticides in agricultural activities (Wu et al, 2010).…”

Section: Discussioncontrasting

confidence: 94%

Determinants of organophosphate pesticide exposure in pregnant women: A population-based cohort study in the Netherlands

Dries

Pronk²,

Guxens

et al. 2018

International Journal of Hygiene and Environmental Health

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Background In the Netherlands organophosphate (OP) pesticides are frequently used for pest control in agricultural settings. Despite concerns about the potential health impacts of low-level OP pesticides exposure, particularly in vulnerable populations, the primary sources of exposure remain unclear. The present study was designed to investigate the levels of DAP metabolites concentrations across pregnancy and to examine various determinants of DAP metabolite concentrations among an urban population of women in the Netherlands. Method Urinary concentrations of six dialkyl phosphate (DAP) metabolites, the main urinary metabolites of OP pesticides, were determined at < 18, 18–25, and > 25 weeks of pregnancy in 784 pregnant women participating in the Generation R Study (between 2004 and 2006), a large population-based birth cohort in Rotterdam, the Netherlands. Questionnaires administered prenatally assessed demographic and lifestyle characteristics and maternal diet. Linear mixed models, with adjustment for relevant covariates, were used to estimate associations between the potential exposure determinants and DAP metabolite concentrations expressed as molar concentrations divided by creatinine levels. Results The median DAP metabolite concentration was 311 nmol/g creatinine for the first trimester, 317 nmol/g creatinine for the second trimester, and 310 nmol/g creatinine for the third trimester. Higher maternal age, married/living with a partner, underweight or normal weight (BMI of < 18.5 and 18.5– < 25), high education, high income, and non-smoking were associated with higher DAP metabolite concentrations, and DAP metabolite concentrations tended to be higher during the summer. Furthermore, fruit intake was associated with increased DAP metabolite concentrations. Each 100 g/d difference in fruit consumption was associated with a 7% higher total DAP metabolite concentration across pregnancy. Other food groups were not associated with higher DAP metabolite concentrations. Conclusions The DAP metabolite concentrations measured in the urine of pregnant women in the Netherlands were higher than those in most other studies previously conducted. Fruit intake was the main dietary source of exposure to OP pesticides in young urban women in the Netherlands. The extent to which DAP metabolite concentrations reflect exposure to the active parent pesticide rather than to less toxic metabolites remains unclear. Further research will be undertaken to investigate the possible effects of this relatively high level OP pesticides exposure on offspring health.

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Section: Discussioncontrasting

confidence: 94%

Determinants of organophosphate pesticide exposure in pregnant women: A population-based cohort study in the Netherlands

Dries

Pronk²,

Guxens

et al. 2018

International Journal of Hygiene and Environmental Health

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“…Outside of the U.S., urinary metabolites have been measured in pregnant women from China (Shanghai (Wang et al, 2012); Shenyang (Zhang et al, 2014)), Mexico (Fortenberry et al, 2014), Netherlands (Ye et al, 2009, 2008), and Norway (Ye et al, 2009). Across these studies, urinary concentrations of OP insecticide metabolites varied widely; geometric mean (GM) urinary concentrations of TCPY ranged between 1.8 ng/ml (Mexico) and 3.6 ng/ml (Netherlands), whereas GM urinary concentrations of diethyl and dimethyl phosphates ranged between <LOD (1.0 ng/ml) (Shenyang, China) and 7.1 ng/ml (Shenyang, China) and 0.7 ng/ml (Netherlands) and 17.2 ng/ml (Shanghai, China), respectively.…”

Section: Discussionmentioning

confidence: 99%

Distribution and determinants of urinary biomarkers of exposure to organophosphate insecticides in Puerto Rican pregnant women

Lewis

Cantonwine

Toro

et al. 2015

Science of The Total Environment

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Globally, human exposures to organophosphate (OP) insecticides may pose a significant burden to the health of mothers and their developing fetuses. Unfortunately, relevant data is limited in certain areas of the world concerning sources of exposure to OP insecticides in pregnant populations. To begin to address this gap in information for Puerto Rico, we studied repeated measures of urinary concentrations of 10 OP insecticide metabolites among 54 pregnant women from the northern karst region of the island. We also collected demographic data and self-reported information on the consumption of fruits, vegetables, and legumes in the past 48-hr before urine collection and home pest-related issues. We calculated the distributions of the urinary biomarkers and compared them to women of reproductive age from the general U.S. population. We also used statistical models accounting for correlated data to assess within-subject temporal variability of the urinary biomarkers and to identify predictors of exposure. We found that for all but two metabolites (para-nitrophenol [PNP], diethylthiophosphate [DETP]), 50th or 95th percentile urinary concentrations (the metric that was used for comparison was based on the biomarker’s detection frequency) of the other eight metabolites (3,5,6-trichloro-2-pyridinol [TCPY], 2-isopropyl-4-methyl-6-hydroxy-pyrimidine, malathion dicarboxylic acid, diethylphosphate, diethyldithiophosphate, dimethylphosphate, dimethylthiophosphate [DMTP], dimethyldithiophosphate) were somewhat lower in our cohort compared with similarly aged women from the continental United States. TCPY, PNP, DETP, and DMTP, which were the only urinary metabolites detected in greater than 50% of the samples, had poor reproducibility (intraclass correlation coefficient range: 0.19–0.28) during pregnancy. Positive predictors of OP insecticide exposure included: age; marital or employment status; consumption of cherries, grape juice, peanuts, peanut butter, or raisins; and residential application of pesticides. Further research is needed to understand what aspects of the predictors identified influence OP insecticide exposure during pregnancy.

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“…Hal tersebut sesuai hasil penelitian di Shenyang, China yang menyebutkan bahwa paparan pestisida jenis organofosfat selama kehamilan mempunyai hubungan yang kuat dengan dampak buruk perkembangan otak bayi baru lahir (Zhang, 2014).…”

Section: Pendahuluanunclassified

Faktor Risiko Paparan Pestisida Selama Kehamilan Terhadap Kejadian BBLR Pada Petani Sayur

Fatmawati¹,

Windraswara

2016

UJPH

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Abstrak ___________________________________________________________________Berat badan lahir rendah (BBLR) menjadi salah satu penyebab utama mortalitas bayi. Permasalahan yang muncul adalah apakah ada hubungan antara paparan pestisida pada masa kehamilan dengan kejadian BBLR di daerah pertanian. Tujuan penelitian ini untuk mengetahui faktor risiko yang berhubungan dengan kejadian BBLR. Penelitian ini merupakanstudi case control. Subjek dibagi menjadi dua kelompok: kelompok kasus sejumlah 25 petani dengan riwayat melahirkan BBLR dan kelompok kontrol yang merupakan tetangga dari subjek kasus tanpa riwayat melahirkan BBLR sejumlah 25 petani. Pengumpulan data penelitian ini menggunakan wawancara dan observasi. Analisis data menggunakan analisis univariat dan bivariat (chi square dan fisher sebagai alternatifnya). Faktor risiko yang terbukti berhubungan dengan kejadian BBLR antara lain: pekerjaan ibu hamil yang berkaitan dengan pestisida (OR = 6,769); kelengkapan alat pelindung diri (APD) saat beraktivitas di ladang (OR= 18,857); dan penyimpanan pestisida (OR= 12,667). Saran yang direkomendasikan adalah menghindari pekerjaan yang berkaitan langsung dengan pestisida selama masa kehamilan, jika memang harus ikut dalam kegiatan pertanian maka ibu hamil sebaiknya menggunakan APD lengkap. (OR= 6,769); personal protective equipment completeness (OR= 18,857); and storage of pesticide (OR= 12,667). Recommended to pregnant farmer to avoid activity with pesticide during pregnancy. Pregnant farmer should use personal protective equipment completely when agricultural activities could not be avoided. Abstract

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Prenatal Exposure to Organophosphate Pesticides and Neurobehavioral Development of Neonates: A Birth Cohort Study in Shenyang, China

Cited by 76 publications

References 50 publications

Determinants of organophosphate pesticide exposure in pregnant women: A population-based cohort study in the Netherlands

Determinants of organophosphate pesticide exposure in pregnant women: A population-based cohort study in the Netherlands

Distribution and determinants of urinary biomarkers of exposure to organophosphate insecticides in Puerto Rican pregnant women

Faktor Risiko Paparan Pestisida Selama Kehamilan Terhadap Kejadian BBLR Pada Petani Sayur

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