Prenatal perfluoroalkyl substance exposure and child adiposity at 8 years of age: The <scp>HOME</scp> study

Braun, Joseph M.; Chen, Aimin; Romano, Megan E.; Calafat, Antònia M.; Webster, Glenys M.; Yolton, Kimberly; Lanphear, Bruce P.

doi:10.1002/oby.21258

Cited by 201 publications

(176 citation statements)

References 38 publications

Supporting

Mentioning

159

Contrasting

Order By: Relevance

“…High PFOS exposure was associated with a higher and steeper postload glucose trajectory, a greater tendency toward glucose intolerance, and a 3.4 times higher prevalence of diabetes, whereas an opposite relationship was found for other congeners of PFASs (PFOA, perfluorononanoic acid, and perfluoroundecanoic acid) (25). Previously published longitudinal studies (12)(13)(14)26,27) have relied on prenatal or perinatal exposure; however, long elimination half-lives of the substances from the human organism pave the way for using childhood PFAS exposure as a proxy for prenatal and postnatal exposure. Previous studies (12)(13)(14) have indicated that exposure to different congeners of PFASs in utero may cause permanent physiological changes, predisposing subjects to later weight gain.…”

Section: Discussionmentioning

confidence: 91%

“…Previously published longitudinal studies (12)(13)(14)26,27) have relied on prenatal or perinatal exposure; however, long elimination half-lives of the substances from the human organism pave the way for using childhood PFAS exposure as a proxy for prenatal and postnatal exposure. Previous studies (12)(13)(14) have indicated that exposure to different congeners of PFASs in utero may cause permanent physiological changes, predisposing subjects to later weight gain. However, other longitudinal studies have not found any relationship between prenatal exposure and anthropometry at 7 years of age (26) or early life exposure and risk of overweight and obesity in adulthood (27).…”

Section: Discussionmentioning

confidence: 99%

“…It may be the antenatal phase, as previously proposed (12)(13)(14), or it may differ according to the health outcomes under observation. In relation to obesity, the time around growth spurts or the adiposity rebound may be particularly vulnerable windows for endocrine disruption in children.…”

Section: Discussionmentioning

confidence: 99%

“…In humans, prenatal exposure to PFASs has been considered a catalyst of later weight gain in longitudinal studies (12)(13)(14). Also cross-sectional studies have linked PFAS exposure to glucose homeostasis, and indicators of the metabolic syndrome in children (15), adolescents, and adults (16).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Longitudinal Associations of Exposure to Perfluoroalkylated Substances in Childhood and Adolescence and Indicators of Adiposity and Glucose Metabolism 6 and 12 Years Later: The European Youth Heart Study

et al. 2016

View full text Add to dashboard Cite

OBJECTIVETo investigate the long-term association of exposure to perfluoroalkylated substances, including perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA), during childhood (9 years) and adolescence (15 years) on indicators of adiposity and glucose metabolism in adolescence (15 years) and young adulthood (21 years). Secondarily, we aim to clarify the degree of tracking of exposure from childhood into young adulthood. RESEARCH DESIGN AND METHODSData derived from a large multicenter prospective cohort study, in which the same participants have been observed from childhood (N = 590), during adolescence (N = 444), and into young adulthood (N = 369). Stored plasma samples were analyzed for PFOS and PFOA. Indicators of adiposity comprising body height, body weight, sum of four skinfolds, and waist circumference, as well as indicators of glucose metabolism, comprising fasting blood glucose, triglyceride, and insulin levels, b-cell function, and insulin resistance, have been collected at all study waves. Multiple linear regression was applied in order to model earlier exposure on later outcome while controlling for baseline outcome levels, sex, age, and socioeconomic factors. RESULTSChildhood exposure to PFOS was associated with indicators of adiposity at 15 years of age that are displayed in elevated BMI, skinfold thickness, and waist circumference, as well as increased skinfold thickness and waist circumference at 21 years of age. PFOA exposure in childhood was associated with decreased b-cell function at 15 years of age. We did not observe associations between exposure during adolescence and indicators of adiposity and glucose metabolism in young adulthood. CONCLUSIONSThis study found evidence for childhood exposure to PFOS and PFOA predicting adiposity at 15 and 21 years of age and impaired b-cell function at 15 years of age, respectively.

show abstract

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Longitudinal Associations of Exposure to Perfluoroalkylated Substances in Childhood and Adolescence and Indicators of Adiposity and Glucose Metabolism 6 and 12 Years Later: The European Youth Heart Study

et al. 2016

View full text Add to dashboard Cite

show abstract

“…No associations were observed for the other PFCs measured (PFOS, PFHxS and PFNA). The investigators noted that their study was limited by the use of less-refined measures of body fatness and that future studies should take advantage of more comprehensive measures such as DXA (32).…”

Section: Discussionmentioning

confidence: 99%

Prenatal Exposure to Perfluoroalkyl Substances and Body Fatness in Girls

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

Short‐Chain Per/Polyfluoroalkyl Acids (C7 and Below)

Lasee,

Dourson,

Onyema

2024

Patty's Toxicology

View full text Add to dashboard Cite

This chapter is about a series of short‐chain per‐ and polyfluoroalkyl substances (PFAS). In the past, PFAS were described as fluorinated fatty acids or sulfonates. The overall structure of PFAS is a carbon chain with fluorine atoms substituting for hydrogen atoms. The resulting chemicals are chemically stable, water and oil resistant, and useful for many industrial applications, such as in the formation of polymers. The most notorious in this group are the fluorinated fatty acids (carboxylates) or sulfonates. In biological systems, these chemicals are generally well‐absorbed by the oral route and resistant to metabolism but also have the unusual property of having drastically different elimination kinetics between mammalian species. The available literature on this group of PFAS (C7 and below) is modest. This chapter will not attempt to review all this literature. Rather, human studies will be emphasized. Since human studies often suggest associations between PFAS exposure and health outcomes, these studies will be followed by definitive experimental animal studies that give insights into the human evidence. Afterward, a summary of attempts to estimate potential human risk by various international agencies will be described. What will become obvious, however, is that the overall uncertainty in the database of some of these chemicals has led to widely divergent risk assessment positions that need to be resolved. Risk management decisions on specific members of this class of chemistries are seen to be premature without such scientific resolution.

show abstract

Prenatal perfluoroalkyl substance exposure and child adiposity at 8 years of age: The HOME study

Cited by 201 publications

References 38 publications

Longitudinal Associations of Exposure to Perfluoroalkylated Substances in Childhood and Adolescence and Indicators of Adiposity and Glucose Metabolism 6 and 12 Years Later: The European Youth Heart Study

Longitudinal Associations of Exposure to Perfluoroalkylated Substances in Childhood and Adolescence and Indicators of Adiposity and Glucose Metabolism 6 and 12 Years Later: The European Youth Heart Study

Prenatal Exposure to Perfluoroalkyl Substances and Body Fatness in Girls

Short‐Chain Per/Polyfluoroalkyl Acids (C7 and Below)

Contact Info

Product

Resources

About