Prenatal Probiotics: The Way Forward in Prevention of Preterm Birth

Dhanasekar, Karukkupalayam Ramasamy; Shilpa, Bennur; Gomathy, Nachimuthu; Shankar, K.

doi:10.14740/jcgo571

Cited by 6 publications

(7 citation statements)

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“…In fact, the colonization rate of the cervicovaginal communities after one cycle of probiotic treatment depends on several factors such as probiotic species, administration route (oral or vaginal), and other individual-dependent variables [52,[63][64][65]. Dhanasekar and coworkers [6] reported that the strains Lactobacillus rhamnosus GR1 and Lactobacillus Reuteri RC14 may persist up to 19 days in the human vagina following intravaginal administration. Both strains survive at low pH, have high adherent ability to uroepithelial and vaginal cells, and are able to colonize the vagina when administered orally, whereas some strains such as Lactobacillus rhamnosus GG and Lactobacillus acidophilus are not well-suited to colonize the vagina or to produce H 2 O 2 (has antimicrobial activity), explaining why both these strains fail to prevent the recurrence of urogenital infections [6].…”

Section: Definition and Characteristicsmentioning

confidence: 99%

“…It is characterized by several clinical and uncomfortable symptoms such as the release of discharge with abnormal vaginal odor, burning with urination, and itching. Additionally, it is linked to the increased risk of early delivery (pre-term delivery) among pregnant women [6]. In many studies, probiotics have been successfully used as a treatment for bacterial vaginosis [12,13]; in this sense, women undergoing bacterial vaginosis and receiving Lactobacillus vaginal tablets revealed the disappearance of bacterial vaginosis symptoms and had a clinically normal vaginal microbiota after daily probiotic therapy application for just 7 days.…”

Section: Benefits Of Probiotic For Female Reproduction 441 Women's Fe...mentioning

confidence: 99%

“…In addition, the administration of Lactobacillus rhamnosus GR1 and reuteri RC14 in pregnant women restores the normal vaginal flora and acidic pH and interrupts the infectious/inflammatory process due to bacterial vaginosis with recovery rates comparable to those of tocolytic therapies. Thus, probiotics are preferred over tocolytic therapy to reduce the adverse maternal and fetal outcomes [6]. Probiotics have been confirmed to tackle other reproductive diseases, even those that are not microbial-pathogen-borne diseases.…”

Section: Benefits Of Probiotic For Female Reproduction 441 Women's Fe...mentioning

confidence: 99%

“…Women [6] Lactobacillus rhamnosus GR1 and Lactobacillus reuteri RC14 Restored the normal vaginal flora and acidic pH Decreased preterm delivery…”

Section: Studies On Womenmentioning

confidence: 99%

“…Many studies have shown the positive effects of probiotics-based therapies on reproductive health in human [6][7][8][9] and animal models [10,11]. Probiotics support reproductive tract eubiosis and the fertility of the host due to their antimicrobial, antioxidant, antiinflammatory, and immunomodulatory activities.…”

Section: Introductionmentioning

confidence: 99%

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The Use of Probiotics for Management and Improvement of Reproductive Eubiosis and Function

Hashem

González-Bulnes

2022

Nutrients

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Reproductive tract dysbiosis, due to the action of pathogens and/or unhealthy lifestyle, has been related to many reproductive diseases and disorders in mammalian species. Classically, such a problem has been confronted by the administration of antibiotics. Despite their effectiveness for controlling disease, treatments with antibiotics may negatively affect the fertility of males and females and, mainly, may induce antibiotic resistance. Accordingly, safer alternatives for maintaining reproductive system eubiosis, such as probiotics, are required. The present review summarizes the current knowledge on the biodiversity of the microbiota at the reproductive tract, possible changes in the case of dysbiosis, and their relationships with adequate reproductive health and functioning in both females and males. Afterwards, mechanisms of action and benefits of different probiotics are weighed since the biological activities of probiotics may provide a promising alternative to antibiotics for maintaining and restoring reproductive eubiosis and function. However, at present, it is still necessary for further research to focus on: (a) identifying mechanisms by which probiotics can affect reproductive processes; (b) the safety of probiotics to the host, specifically when consumed during sensitive reproductive windows such as pregnancy; and (c) the hazards instructions and regulatory rules required for marketing these biological-based therapies with sufficient safety. Thus, in this review, to draw a comprehensive overview with a relatively low number of clinical studies in this field, we showed the findings of studies performed either on human or animal models. This review strategy may help provide concrete facts on the eligible probiotic strains, probiotics colonization and transfer route, and prophylactic and/or therapeutic effects of different probiotic strains.

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Section: Definition and Characteristicsmentioning

confidence: 99%

Section: Benefits Of Probiotic For Female Reproduction 441 Women's Fe...mentioning

confidence: 99%

Section: Benefits Of Probiotic For Female Reproduction 441 Women's Fe...mentioning

confidence: 99%

“…Women [6] Lactobacillus rhamnosus GR1 and Lactobacillus reuteri RC14 Restored the normal vaginal flora and acidic pH Decreased preterm delivery…”

Section: Studies On Womenmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Use of Probiotics for Management and Improvement of Reproductive Eubiosis and Function

Hashem

González-Bulnes

2022

Nutrients

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Vaginal and oral probiotics effect in the prevention of preterm delivery in patients visiting Kamali Hospital, Karaj, Iran in 2020

Solgi

Tavakoli‐Far²,

Badehnoosh³

et al. 2022

European Journal of Obstetrics & Gynecology and Reproductiv

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The features of complex therapy of bacterial vaginosis in pregnant women with cervical incompetence

Konkov

Adamchuk

Klivak

2020

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Objective of the study: to study the clinical and laboratory efficacy of the Femivag® (contains Lactobacillus gasseri, Lactobacillus rhamnosus) drug in the complex treatment of bacterial vaginosis (BV) in pregnant women with high risk of preterm birth.Materials and methods. 42 pregnant women at the 16–18 weeks of gestation with cervical dysfunction and BV diagnosed before cervical pessary installation were examined and treated. All patients were assessed the dynamics of symptoms severity, performed PCR testі with a quantitative count of opportunistic pathogens and Lactobacillus spp. Perinatal and neonatal outcomes were also assessed. Femivag® vaginal capsules were prescribed to 24 women (main group) to restore the vaginal microbiota after BV treatment. 18 pregnant women used dietary supplements containing pro- and prebiotics (comparison group). The examination was performed before treatment, 4 and 15–16 days from the therapy start, 4 and 8 weeks after treatment.Results. Vaginal probiotic Femivag® as a component of complex therapy of BV before the installation of cerclage pessary was more effective than the oral food supplements with pro- and prebiotics in terms of reducing in vaginal discharge and vaginal discomfort, the disappearance of vaginal itching and burning sensation for 4 days of therapy. Gardnerella vaginalis / Prevotella bivia / Porphyromonas spp., Mobiluncus spp. / Corynebacterium spp. and Atopobium vaginae disappeared and vaginal normobiota significant recovered in the second trimester in women with cervical dysfunction at 4 and 8 weeks from the start of BV treatment with Femivag®. Frequency of premature rupture of membranes and chorioamnionitis significantly decreased in the main group. Femivag® was well tolerated and had no side effects.Conclusions. Femivag® vaginal capsules had a pronounced clinical and laboratory effect in the complex treatment of BV in pregnant women with incompetent cervix

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Prenatal Probiotics: The Way Forward in Prevention of Preterm Birth

Cited by 6 publications

References 0 publications

The Use of Probiotics for Management and Improvement of Reproductive Eubiosis and Function

The Use of Probiotics for Management and Improvement of Reproductive Eubiosis and Function

Vaginal and oral probiotics effect in the prevention of preterm delivery in patients visiting Kamali Hospital, Karaj, Iran in 2020

The features of complex therapy of bacterial vaginosis in pregnant women with cervical incompetence

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