Preoperative abdominal fat distribution and systemic immune inflammation were associated with response to intravesical Bacillus Calmette-Guerin immunotherapy in patients with non-muscle invasive bladder cancer

Ke, Zhi‐Bin; Chen, Hang; Chen, Jia-Yin; Cai, Hai; Lin, Yunzhi; Sun, Xiong‐Lin; Huang, Jiaofeng; Zheng, Qing‐Shui; Wei, Yong; Xue, Xue-Yi; Xu, Ning

doi:10.1016/j.clnu.2021.10.019

Cited by 20 publications

(39 citation statements)

References 32 publications

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“…Finally, 10 studies that comprised 7,087 patients were included in this meta-analysis ( 9 – 13 , 16 – 20 ). All the included studies have been published within the last 3 years (2019–2021); five studies focused on NMIBC ( 11 , 16 , 17 , 19 , 20 ) and the other five studies on MIBC ( 9 , 10 , 12 , 13 , 18 ). Notably, all of the 10 studies were retrospective, and six of them had been conducted in China ( 9 , 11 , 12 , 16 , 19 , 20 ), two in Europe and United States ( 10 , 17 ), one in Turkey ( 13 ), and one in Japan ( 18 ).…”

Section: Resultsmentioning

confidence: 99%

“…All the included studies have been published within the last 3 years (2019–2021); five studies focused on NMIBC ( 11 , 16 , 17 , 19 , 20 ) and the other five studies on MIBC ( 9 , 10 , 12 , 13 , 18 ). Notably, all of the 10 studies were retrospective, and six of them had been conducted in China ( 9 , 11 , 12 , 16 , 19 , 20 ), two in Europe and United States ( 10 , 17 ), one in Turkey ( 13 ), and one in Japan ( 18 ). The sample size in the included studies ranged from 79 to 4,335 patients, with the median patient age ranging from 53.6 to 73 years, and the cutoff values of SII ranged from 276 to 896.…”

Section: Resultsmentioning

confidence: 99%

“…Although previous studies have explored the prognostic value of SII in BC patients, the results were not consistent. SII was considered an important prognostic factor in some studies ( 9 – 11 ), whereas other studies have found no significant association between SII and survival outcomes of BC ( 12 , 13 ). Therefore, this study aimed to use the available data to evaluate the prognostic role of preoperative SII in patients with BC and the association between SII and clinicopathological features of BC.…”

Section: Introductionmentioning

confidence: 99%

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The Prognostic and Clinicopathological Significance of Systemic Immune-Inflammation Index in Bladder Cancer

Cao

Huang

et al. 2022

Front. Immunol.

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BackgroundSystemic immune-inflammation index (SII) has recently emerged as a biomarker for the prognosis of a variety of malignant tumors. However, the role of SII in bladder cancer (BC) remains unclear. To this end, we performed a pooled analysis to investigate the prognostic value of preoperative SII in patients with BC.MethodsA comprehensive search of electronic databases (PubMed/Medline, Web of Science, Scopus, and Cochrane Central Register of Controlled Trials) was conducted to determine the eligible studies that were published until January 2022. Pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the association between preoperative SII and the prognosis and clinicopathological characteristics of BC.ResultsTen studies with 7,087 patients were included in this analysis. SII was observed to be correlated with inferior overall survival (HR = 1.22, 95% CI 1.04–1.44, p = 0.013), cancer-specific survival (HR = 1.68, 95% CI 1.14–2.47, p = 0.009), and recurrence-free survival (HR = 1.29, 95% CI 1.03–1.61, p = 0.027). An increased preoperative SII was also associated with poor tumor differentiation, higher tumor stage, presence of lymph node involvement, and tumor size ≥3 cm (all p < 0.05).ConclusionsAn elevated preoperative SII is significantly associated with worse survival outcomes and adverse pathological features in patients with BC. Hence, SII may serve as a strong independent prognostic predictor for patients with BC after surgery.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Prognostic and Clinicopathological Significance of Systemic Immune-Inflammation Index in Bladder Cancer

Cao

Huang

et al. 2022

Front. Immunol.

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“…Full texts of 17 studies were then reviewed, with 7 studies excluded. Finally, 10 studies that comprised 7,087 patients were included in this meta-analysis (9)(10)(11)(12)(13)(16)(17)(18)(19)(20). All the included studies have been published within the last 3 years (2019-2021); five studies focused on NMIBC (11,16,17,19,20) and the other five studies on MIBC (9,10,12,13,18).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Although previous studies have explored the prognostic value of SII in BC patients, the results were not consistent. SII was considered an important prognostic factor in some studies (9)(10)(11), whereas other studies have found no significant association between SII and survival outcomes of BC (12,13). Therefore, this study aimed to use the available data to evaluate the prognostic role of preoperative SII in patients with BC and the association between SII and clinicopathological features of BC.…”

Section: Introductionmentioning

confidence: 99%

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Preoperative systemic immune‐inflammation index as a significant prognostic factor after TURBT in patients with non‐muscle‐invasive bladder cancer: A retrospective study based on propensity score matching analysis

et al. 2022

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Objective To investigate the association of the preoperative systemic immune‐inflammation index (SII) with recurrence‐free survival (RFS) after transurethral resection of the bladder tumor (TURBT) of non‐muscle‐invasive bladder cancer (NMIBC) using propensity score matching (PSM) analysis. Methods The clinicopathological characteristics and follow‐up data of NMIBC patients were collected retrospectively from two tertiary medical centers. A 1:1 PSM analysis was carried out using the nearest‐neighbor method (caliper size: 0.02). Cox regression analysis was used to identify the risk factors associated with RFS. Results A total of 416 NMIBC patients were included in this study. Before and after matching, patients with increased SII had worse RFS ( p < 0.0001 and p = 0.027, respectively). Multivariate Cox analysis identified SII as an independent predictor of RFS before (HR [95% CI]: 1.789 [1.232, 2.599], p = 0.002) and after matching (HR [95% CI]: 1.646 [1.077, 2.515], p = 0.021). In the matched subgroup analysis, an elevated SII had a significant association with postoperative worse RFS in the T1 stage ( p = 0.025), primary status ( p = 0.049), high‐grade ( p = 0.0015), and multiple lesions ( p = 0.043) subgroups. Conclusion SII could accurately stratify the prognosis of NMIBC patients before and after PSM analysis. An elevated SII was significantly associated with worse RFS in NMIBC patients.

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Preoperative abdominal fat distribution and systemic immune inflammation were associated with response to intravesical Bacillus Calmette-Guerin immunotherapy in patients with non-muscle invasive bladder cancer

Cited by 20 publications

References 32 publications

The Prognostic and Clinicopathological Significance of Systemic Immune-Inflammation Index in Bladder Cancer

The Prognostic and Clinicopathological Significance of Systemic Immune-Inflammation Index in Bladder Cancer

DataSheet_1.zip

Preoperative systemic immune‐inflammation index as a significant prognostic factor after TURBT in patients with non‐muscle‐invasive bladder cancer: A retrospective study based on propensity score matching analysis

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