Preoperative chest computerized tomography in patients with locally advanced mid or lower rectal cancer: Its role in staging and impact on treatment strategy

Choi, Duck Joo; Kwak, Jungwon; Kim, Jin; Woo, Si Uk; Kim, Seon Hahn

doi:10.1002/jso.21651

Cited by 39 publications

(21 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We agree with previous authors that finding indeterminate PNs should not prompt any modification of the treatment plan for primary colorectal cancer [14,17,30,33], but the diagnostic issue becomes particularly important in the patients concerned, because the treatment options that include surgery and chemotherapy, or some combination of them, improve for metastatic disease [34][35][36].…”

Section: Discussionsupporting

confidence: 90%

“…Unfortunately, PET/CT can usually only detect nodules more than 10 mm in size [18]; percutaneous needle biopsy may be impossible or uninformative for the purposes of an accurate pathological diagnosis, depending on the size and site of nodules [31]; and video-assisted thoracoscopic biopsy is too invasive to be performed routinely [32]. Chest CT revealed growing nodules in a larger proportion of patients in our series (19/92; 20.6 %) than in other published studies, where the overall rate of ultimate diagnosis of malignancy ranged from 6.3 to 16.6 % in colorectal cancer patients found to have PNs [14,30,33]. This discrepancy may be influenced by the grounds on which pulmonary metastases are suspected, which frequently rely on inference because no final histological diagnosis is available.…”

Section: Discussionmentioning

confidence: 48%

“…There is a paucity of literature on the effectiveness of imaging in detecting pulmonary metastases in already-diagnosed colorectal cancer. The available studies concentrated on specific concerns, such as the utility of lower chest CT images [9], the significance of PNs in primary rectal cancer revealing positive local lymph nodes at histopathology [14], or the clinical relevance of PNs in patients undergoing resection surgery for colorectal cancer liver metastases [15]. Although CT is considered the most appropriate technique for detecting pulmonary metastases [16][17][18], an internationally shared consensus on the optimal imaging follow-up for colorectal cancer patients has yet to take shape.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Significance of pulmonary nodules in patients with colorectal cancer

et al. 2012

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 48%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Significance of pulmonary nodules in patients with colorectal cancer

et al. 2012

View full text Add to dashboard Cite

show abstract

“…MRI performed with liver-specific contrast agents has > 90% sensitivity in cases of underlying liver disease (steatosis, cirrhosis) or very small lesions (< 1 cm). For this reason MRI is better than CT for metastasis detection[26]. …”

Section: Radiological Assessmentmentioning

confidence: 99%

Multidisciplinary approach of colorectal cancer liver metastases

Fiorentini

Sarti

Aliberti

et al. 2017

WJCO

View full text Add to dashboard Cite

Large bowel cancer is a worldwide public health challenge. More than one third of patients present an advanced stage of disease at diagnosis and the liver is the most common site of metastases. Selection criteria for early diagnosis, chemotherapy and surgery have been recently expanded. The definition of resectability remains unclear. The presence of metastases is the most significant prognostic factor. For this reason the surgical resection of hepatic metastases is the leading treatment. The most appropriate resection approach remains to be defined. The two step and simultaneous resection processes of both primary and metastases have comparable survival long-term outcomes. The advent of targeted biological chemotherapeutic agents and the development of loco-regional therapies (chemoembolization, thermal ablation, arterial infusion chemotherapy) contribute to extend favorable results. Standardized evidence-based protocols are missing, hence optimal management of hepatic metastases should be single patient tailored and decided by a multidisciplinary team. This article reviews the outcomes of resection, systemic and loco-regional therapies of liver metastases originating from large bowel cancer.

show abstract

“…Frequency was nearly three times higher for patients with rectal cancer than for patients with colon cancer. Smaller studies [42][43][44] have shown isolated lung metastases in 9-18% of patients with rectal cancer; although distant metastases can be identified in other organs including the bone and the brain [38].…”

Section: Introductionmentioning

confidence: 99%

High-Risk Human Papillomavirus and Colorectal Carcinogenesis

Moustafa¹,

Al-Antary²,

Yasmeen³

2016

Human Papillomavirus - Research in a Global Perspective

View full text Add to dashboard Cite

Colorectal, colon and rectal, cancer is the third most common malignancy in both men and women worldwide. Colorectal carcinogenesis is a complex, multistep process implicating environmental and lifestyle factors in addition to gene mutation and viral infections. On the other hand, it is well established that human papillomaviruses (HPVs) infection play a crucial role in certain types of human carcinomas including cervical and head and neck (HN); as roughly 96% and 30% of these cancers are positive for high-risk HPVs, respectively. Moreover, it has been reported that the presence of high-risk HPVs is associated with vascular invasion, lymph node metastases, and tumor size in cervical and HN cancers. Recently, several investigations pointed-out that high-risk HPVs are present in around 70% of human colorectal cancers. Likewise, our group has demonstrated that E6/E7 oncoproteins of HPV type 16 convert noninvasive and nonmetastatic human cancer cells to invasive and metastatic form. Accordingly, it is evident that high-risk HPVs are present in human colorectal cancers where they could play an important role in the development of these malignancies. In this chapter, we will discuss the presence and role of high-risk HPVs in human colorectal carcinogenesis and metastasis; particularly, the interaction between E5 and E6/E7 oncoproteins of high-risk HPVs in colorectal malignancies, which has been linked with the initiation and progression of these tumors.

show abstract

Preoperative chest computerized tomography in patients with locally advanced mid or lower rectal cancer: Its role in staging and impact on treatment strategy

Abstract: It seems reasonable to perform chest CT for preoperative staging in patients with T3/T4 mid or lower rectal cancer.

Cited by 39 publications

References 18 publications

Significance of pulmonary nodules in patients with colorectal cancer

Significance of pulmonary nodules in patients with colorectal cancer

Multidisciplinary approach of colorectal cancer liver metastases

High-Risk Human Papillomavirus and Colorectal Carcinogenesis

Contact Info

Product

Resources

About