“…The target of the peripheral nerve block for a median sternotomy or intercostal incision is the anterior/ventral branches of the spinal cord, that is, the intercostal nerves. The intercostal nerves arise from the anterior rami of the thoracic spinal nerves and run between the innermost and inner intercostal muscles, branching off collateral and lateral cutaneous branches along the way, and finally become anterior cutaneous branches and are distributed in the lateral and front sides of the chest wall, respectively, innervating sensory supply to the skin, soft tissue, and muscle on the anterior aspect of the trunk, including the sternum [ 34 , 35 ▪ , 36 ▪ , 37 ▪ ]. Consequently, blocking the intercostal nerve at any approachable site is the theory of peripheral nerve block for cardiac surgery with median sternotomy, as well as the intercostal approach (Fig.…”