Preoperative prediction of histopathological outcome in basal cell carcinoma: flat surface and multiple small erosions predict superficial basal cell carcinoma in lighter skin types

Ahnlide, Ingela; Zalaudek, Iris; La, Nilsson; Bjellerup, Mats; Nielsen, Kari

doi:10.1111/bjd.14499

Cited by 39 publications

(43 citation statements)

References 25 publications

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“…27 In 2016 a two part study of optional then mandatory dermoscopy use, the overall diagnostic sensitivity of basal cell carcinoma (BCC) was 93.3% (91.9–94.5) and specificity was 91.8% (90.6–93.0). 28 Furthermore, dermoscopy when compared to NEE was shown to help predict BCC histopathology subtypes. 28 In the following sections, we will detail further the specific diagnostic features of KC.…”

Section: Dermoscopy For the Diagnosis And Management Of Keratinocyte mentioning

confidence: 99%

“…28 Furthermore, dermoscopy when compared to NEE was shown to help predict BCC histopathology subtypes. 28 In the following sections, we will detail further the specific diagnostic features of KC.…”

Section: Dermoscopy For the Diagnosis And Management Of Keratinocyte mentioning

confidence: 99%

“…30–32 Studies have demonstrated that certain dermoscopic structures and patterns are associated with different subtypes of BCC. 28,33 The presence of spoke-wheel and leaflike structures, multiple small erosions, short fine vessels and shiny white blotches and strands in a nonpalpable lesion are associated with superficial BCC. In contrast, the presence of blue-grey globules, ovoid nest, arborizing vessels and ulceration are associated with nodular BCC.…”

Section: Dermoscopic Features In Basal Cell Carcinomamentioning

confidence: 99%

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Enhancing Skin Cancer Diagnosis with Dermoscopy

Wolner

Yélamos

Liopyris

et al. 2017

Dermatologic Clinics

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Synopsis Dermoscopy increases the sensitivity for skin cancer detection, decreases the number of benign lesions biopsied for each malignant diagnosis, and enables the diagnosis of thinner melanomas compared to naked eye examination. Three meta-analyses have all identified that dermoscopy improved diagnostic accuracy for melanoma when compared to naked eye exam. In addition, studies have established that dermoscopy can aid in the detection of keratinocyte carcinomas. Dermoscopy triage algorithms have been developed to help novices decide when a biopsy or a referral is most appropriate. In this chapter we illustrate the dermoscopic features that assist in identifying melanoma and keratinocyte carcinomas.

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Section: Dermoscopy For the Diagnosis And Management Of Keratinocyte mentioning

confidence: 99%

Section: Dermoscopy For the Diagnosis And Management Of Keratinocyte mentioning

confidence: 99%

Section: Dermoscopic Features In Basal Cell Carcinomamentioning

confidence: 99%

See 1 more Smart Citation

Enhancing Skin Cancer Diagnosis with Dermoscopy

Wolner

Yélamos

Liopyris

et al. 2017

Dermatologic Clinics

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“…Dermoscopy has significantly increased the accuracy in diagnosing BCC and several specific criteria have been described so far [6]. Furthermore, dermoscopy has also been proven to be useful in BCC subtype prediction, presurgical margin definition, and posttreatment assessment [7][8][9]. To date, only few reports have focused on dermoscopic features of BCC according to body site; in particular, there is a lack of data on BCC located on the lower limbs [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Dermoscopic Features of Basal Cell Carcinoma on the Lower Limbs: A Chameleon!

et al. 2017

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Background:Lower limbs represent an uncommon location for basal cell carcinoma (BCC) and only few reports have described dermoscopic features of BCC in this body site. Since BCCs of the lower limbs frequently display nonclassic BCC dermoscopic criteria, they can simulate other benign or malignant lesions. Objective: Our aim was to describe the dermoscopic features of BCC located on lower limbs and to define which criteria were more associated with their benignor malignant-looking appearance. Methods: We conducted a retrospective study enrolling consecutive patients with histologically confirmed BCCs of the lower limbs. Lesions were classified in 7 categories according to the clinical and dermoscopic global appearance. Clear BCC, squamous cell carcinoma (SCC) or Bowen disease-like, Kaposi disease-like, melanoma-like, and aspecific pattern were considered malignant-looking lesions; however, seborrheic keratosis-like and dermatofibroma-like were considered benign-looking. To define which dermoscopic criteria were independently associated with benign-or malignant-looking appearance, we conducted a multivariate logistic regression analysis. Results:A total of 81 BCCs were enrolled: 18 (22%) were benign-looking lesions (of which 11 were seborrheic keratosis-like and 7 dermatofibroma-like) and 63 (78%) were malignant-looking BCCs (of which 24 were clear-cut BCCs, 23 SCC-like, 2 Kaposi disease-like, 9 melanoma-like, and 5 had aspecific pattern). Multivariate regression analysis showed that erosions/ulceration and vessels were independently associated with malignant-looking appearance. The most represented vessels were glomerular and polymorphic, which are more frequently encountered in SCC, together with ulceration. Conclusion: BCC of the lower legs frequently simulates other benign or malignant lesions, with SCC being the main differential diagnosis.

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“…The named criteria are in consistency with the lesion being an initial BCC before the development of more common criteria according to the known correlations between dermatoscopic and morphological signs [22-27]. In particular, superficial fine telangiectasia and arborizing vessels with a small diameter have been associated with superficial BCCs [25, 26]. Translucency, also called semitranslucency, that can be seen both clinically and dermatoscopically as near-skin-tone colored, smooth, jellylike appearance has been suggested as a dermatoscopic sign of early BCCs measuring only 3–4 mm in diameter [22, 23].…”

Section: Discussion/conclusionmentioning

confidence: 91%

Treatment of Actinic Keratoses Facilitates Dermatoscopic Diagnosis of Early Basal Cell Carcinoma: A Case Report and Review

et al. 2019

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Chronic exposure to ultraviolet radiation induces gradual changes in cutaneous morphology, which with increasing damage leads to the appearance of cancerous skin lesions. Among them, basal cell carcinomas (BCCs) and actinic keratoses (AKs) are the most common entities. Both lesions often develop as two separate lesions in a single individual at a conspicuous distance, close proximity or as collision lesions, which are characterized by the coexistence of both cancers in the same anatomical site. Collision lesions in which AK precisely overlies BCC is a rarely reported entity. We report a case where the presence of BCC was dermatoscopically detected after an overlying AK was treated with topical chemotherapy, thus indicating that treatment of AK allows better visualization of other underlying malignancies.

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Preoperative prediction of histopathological outcome in basal cell carcinoma: flat surface and multiple small erosions predict superficial basal cell carcinoma in lighter skin types

Cited by 39 publications

References 25 publications

Enhancing Skin Cancer Diagnosis with Dermoscopy

Enhancing Skin Cancer Diagnosis with Dermoscopy

Dermoscopic Features of Basal Cell Carcinoma on the Lower Limbs: A Chameleon!

Treatment of Actinic Keratoses Facilitates Dermatoscopic Diagnosis of Early Basal Cell Carcinoma: A Case Report and Review

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