Preoperative serum value of sialyl Lewis X predicts pathological nodal extension and survival in patients with surgically treated small cell lung cancer

Iwata, Takashi; Nishiyama, Noritoshi; Nagano, Koshi; Izumi, Nobuhiro; Tsukioka, Takuma; Chung, Kyukwang; Hanada, Shoji; Inoue, Kiyotoshi; Kaji, Masahide; Suehiro, Shigefumi

doi:10.1002/jso.23002

Cited by 42 publications

(14 citation statements)

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“…Thus, accurate clinical staging is difficult even using various image diagnoses such as PDG PET because it is not always correlated with the actual pathological stage, and it remains very important to predict the accurate lymph nodal extension preoperatively to determine the surgical indication. Previously, we have reported that preoperative serum sialyl Lewis X (SLX) is useful for the prediction of pathological nodal extension and survival in SCLC [39]. The present study demonstrated that A B serum CPLX2 levels in high grade LNETs were significantly elevated as compared to NSCLCs and NCs.…”

Section: Discussionsupporting

confidence: 47%

Complexin-2 (CPLX2) as a potential prognostic biomarker in human lung high grade neuroendocrine tumors

Komatsu

Kakehashi

Nishiyama

et al. 2013

CBM

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The present study aimed to identify novel useful clinical biomarker of high grade lung neuroendocrine tumors (LNETs). Based on the results of QSTAR LC-MS/MS analysis, we selected complexin-2 (CPLX2) (upregulated 8.7-fold) as a potential biomarker in high grade human LNETs, and validated its expression immunohistochemically in comparison with non-small cell lung carcinomas (NSCLCs). CPLX2 was strongly positive in 16.3% of examined LNETs, but completely negative in all adjacent non-cancerous tissues and NSCLCs. Importantly, positive CPLX2 expression was associated with lymph vessel invasion (P=0.016), pathological stage (P=0.031), and poor disease-specific survival (P=0.004) of patients with LNETs. Preoperative serum CPLX2 level measured by ELISA was significantly elevated in high grade LNETs as compared with %NCs non-cancer controls (NCs) (P=0.002) and NSCLCs (P< 0.001). Receiver operating characteristic (ROC) curve analysis was used for separating high-grade LNET patients from NSCLC patients. The area under the ROC curve (AUC) was 0.825. The calculated optimal cut-off point for CPLX2 level in the serum was 17.8 pg/ml (Youden index=0.591), while sensitivity and specificity was 94.1% and 65.0%, respectively. CPLX2 is suggested as a novel potential clinically useful biomarker for the diagnosis, prognosis and adequate choice of therapy for patients with high grade LNETs.

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Section: Discussionsupporting

confidence: 47%

Complexin-2 (CPLX2) as a potential prognostic biomarker in human lung high grade neuroendocrine tumors

Komatsu

Kakehashi

Nishiyama

et al. 2013

CBM

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“…The determined SialylLewis x structure here is in agreement with previous studies that reported the presence of SialylLewis x in malignancies [ 15 – 22 ]. SialylLewis x is an adhesion molecule present on O-and N-linked oligosaccharides, and is therefore of great significance in cell-cell recognition [ 23 ]. Importantly, SialylLewis x is thought to be associated with metastatic ability of tumor cells, and has the potential to be used as a marker for pathological tumor extensiveness, e.g., nodal extension or distant metastasis [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Glycomic profiling of carcinoembryonic antigen isolated from human tumor tissue

et al. 2015

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BackgroundCarcinoembryonic antigen (CEA) is a protein commonly found in human serum, with elevated CEA levels being linked to the progression of a wide range of tumors. It is currently used as a biomarker for malign tumors such as lung cancer and colorectal cancer [Urol Oncol: Semin Orig Invest 352: 644–648, 2013 and Lung Cancer 80: 45-49, 2013]. However, due to its low specificity in clinical applications, CEA can be used for monitoring only, rather than tumor diagnosis. The function of many glycoproteins is critically dependent on their glycosylation pattern, which in turn has the potential to serve in tumor detection. However, little is known about the detailed glycan patterns of CEA.MethodsTo determine these patterns, we isolated and purified CEA proteins from human tumor tissues using immunoaffinity chromatography. The glycan patterns of CEA were then analyzed using a Matrix-Assisted Laser Desorption/Ionization-Time of Flight-Mass Spectrometry3 (MALDI-TOF-MS3) approach.ResultsWe identified 61 glycoforms in tumor tissue, where CEA is upregulated. These glycosylation entities were identified as bi-antennary, tri-antennary and tetra-antennary structures carrying sialic acid and fucose residues, and include a multitude of glycans previously not reported for CEA.ConclusionOur findings should facilitate a more precise tumor prediction than currently possible, ultimately resulting in improved tumor diagnosis and treatment.Electronic supplementary materialThe online version of this article (doi:10.1186/s12014-015-9088-3) contains supplementary material, which is available to authorized users.

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“…A drought event is defined when SPI (3) reaches a value of −0.5 or less (Xu and Luo, 2019). Three drought conditions from mild (D_I), moderate (D_II) to severe (D_III) are defined using different SPI (3) thresholds (Thomas et al, 1993) (Table 2).…”

Section: Methodsmentioning

confidence: 99%

Changes of compound hot and dry extremes on different land surface conditions in China during 1957–2018

Yao

Liu

Sun

et al. 2020

Intl Journal of Climatology

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The co-occurrence of hot and dry extremes (compound hot and dry extreme, CHDE) has attracted much attention due to the amplified impact on wildfire occurrence, agriculture production and human health. Most existing studies have reported the spatiotemporal variations of CHDE, changes in CHDE on different land surface conditions are barely discussed. The study investigated the spatial and temporal differences of CHDE over different regions and land covers in China during 1957-2018. On average over China, both day-and night-time CHDEs have increased with a more rapid (2.6 times faster) and significant (p < .05) increasing trend in night-time ones. Increasing trends are mainly distributed in north China with decreasing trends in central China. Moreover, increasing trends in night-time mildly dry (0.07 per decade) and moderately hot (0.06 per decade) CHDEs are the largest among all dry and hot CHDEs. Regionally, the frequency of CHDE is the highest over the humid and sub-humid regions for night-and daytime CHDEs, but the lowest for both over the arid region. Meanwhile, CHDE has increased over the humid and sub-humid regions in the recent decade but decreased over the arid region since 1957. For different land covers, the frequency of CHDE is the highest over forest but the lowest over grassland. Daytime CHDEs of different hot magnitudes indicate the largest increasing trends over grassland caused by the largest increasing trends of daytime heatwave. Significant (p < 0.05) increasing trends of day-and night-time CHDEs over forest may increase the risks of tree mortality or forest fires after 2010 and larger increasing trends in nighttime CHDEs over urban may negatively impact human health.

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Preoperative serum value of sialyl Lewis X predicts pathological nodal extension and survival in patients with surgically treated small cell lung cancer

Abstract: Serum SLX values were associated with pathological stage and survival after surgery in SCLC patients.

Cited by 42 publications

References 10 publications

Complexin-2 (CPLX2) as a potential prognostic biomarker in human lung high grade neuroendocrine tumors

Complexin-2 (CPLX2) as a potential prognostic biomarker in human lung high grade neuroendocrine tumors

Glycomic profiling of carcinoembryonic antigen isolated from human tumor tissue

Changes of compound hot and dry extremes on different land surface conditions in China during 1957–2018

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