Preparação de nanopartículas poliméricas a partir de polímeros pré-formados: parte II

Abstract

<jats:p>Nanopartículas poliméricas produzidas a partir de polímeros pré-formados, como os poliésteres alifáticos, têm sido amplamente utilizadas para incorporar, principalmente, princípios ativos lipofílicos. A produção das nanopartículas (nanocápsulas e nanosferas) por polímeros pré-formados pode ser realizada por emulsificação-evaporação do solvente, por deslocamento do solvente, por salting-out ou por emulsificação-difusão do solvente. Estes métodos de produção estão revisados e descritos neste artigo, evidenciando os parâmetros tecnológicos que interferem nas características físico-químicas das nanopartículas, como a solubilidade do princípio ativo, o volume e pH do meio de polimerização, a massa molar e concentração do monômero e a natureza e concentração do tensoativo.</jats:p>

Characterization of Nanospheres Containing Zanthoxylum riedelianum Fruit Essential Oil and Their Insecticidal and Deterrent Activities against Bemisia tabaci (Hemiptera: Aleyrodidae)

“…The stability of the nanoparticulate systems was maintained by employing a high hydrophilic–lipophilic balance (HLB) surfactant—Tween ® 80—which has the purpose of preventing particle coalescence and diffusion of the encapsulated active substance. The low HLB surfactant, Span ® 60, present in the organic phase, is necessary to obtain a population of nanospheres with a small and homogeneous size [ 35 , 36 ]. The stability and uniformity of the suspensions were evaluated by their pH, zeta potential (ZP), particle diameter (PD), and polydispersity index (PdI) values.…”

Development and evaluation of organic silicon nanoparticles

“…The suspension of Silicium P ® nanoparticles (NSiP) was prepared by the double emulsification-solvent evaporation technique 7 . Firstly, the polyvinyl alcohol (PVAL) was solubilized in ultra-purified water at a temperature of 40 °C under mechanical stirring, separately the poly (ε-caprolactone) (PCL) in chloroform was solubilized at room temperature under mechanical stirring.…”

Nanotechnological strategies for systemic microbial infections treatment: A review

“…However, some drawbacks have been reported, limiting the use of polymerization methods for PNs synthesis. Thus, the preparation using preformed polymers is more easily controllable, higher yielding and can be performed by solvent emulsification-evaporation, solvent displacement or nanoprecipitation, solvent emulsification-diffusion or salting-out ( Crucho and Barros, 2017 , Souto et al, 2012 ).…”