Preparation and antibacterial activity of chitosan derivative membrane complexation with iodine

Xu, Nai; Ding, Dawei

doi:10.1039/c5ra13227d

Cited by 22 publications

(8 citation statements)

References 48 publications

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“…The FTIR spectra of MTZ and iodine-loaded trilayered fibers were compared to those of pure MTZ and PVP-I, to confirm the entrapment of the active ingredients in the fibers (Figure 4). Free iodine interacts with the negative end of the C=O dipole of PVP molecules, forming a complex with the amide functional group and is identified as a characteristic peak around 1654 cm −1 [26,27]. This characteristic peak was seen in the PVP-I spectrum as well as the fibers, confirming the presence of iodine.…”

Section: Compositional Featuresmentioning

confidence: 89%

A Portable Device for the Generation of Drug-Loaded Three-Compartmental Fibers Containing Metronidazole and Iodine for Topical Application

et al. 2020

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The use of combination therapies for the treatment of a range of conditions is now well established, with the component drugs usually being delivered either as distinct medicaments or combination products that contain physical mixes of the two active ingredients. There is, however, a compelling argument for the development of compartmentalised systems whereby the release, stability and incorporation environment of the different drugs may be tailored. Here we outline the development of polymeric fine fiber systems whereby two drugs used for the treatment of wounds may be separately incorporated. Fibers were delivered using a newly developed handheld electrospinning device that allows treatment at the site of need. Crucially, the delivery system is portable and may be used for the administration of drug-loaded fibers directly into the wound in situ, thereby potentially allowing domiciliary or site-of-trauma administration. The three-layered fiber developed in this study has polyethylene glycol as the outermost layer, serving as a structural support for the inner layers. The inner layers comprised iodine complexed with polyvinylpyrrolidone (PVP) and metronidazole dispersed in polycaprolactone (PCL) as a slow release core. The systems were characterized in terms of structure and architecture using scanning electron microscopy, transmission electron microscopy, attenuated total reflection Fourier transform infrared spectroscopy and diffractometry. As antibacterial creams are still used for managing infected wounds, the performance of our trilayered fiber was studied in comparison with creams containing similar active drugs. Drug release was measured by UV analysis, while antimicrobial efficiency was measured using agar diffusion and suspension methods. It was found that the trilayered systems, averaging 3.16 µm in diameter, released more drug over the study period and were confirmed by the microbacterial studies to be more effective against P. aeruginosa, a bacterium commonly implicated in infected wounds. Overall, the portable system has been shown to be capable of not only incorporating the two drugs in distinct layers but also of delivering adequate amounts of drugs for a more effective antibacterial activity. The portability of the device and its ability to generate distinct layers of multiple active ingredients make it promising for further development for wound healing applications in terms of both practical applicability and antimicrobial efficacy.

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Section: Compositional Featuresmentioning

confidence: 89%

A Portable Device for the Generation of Drug-Loaded Three-Compartmental Fibers Containing Metronidazole and Iodine for Topical Application

et al. 2020

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“…It was observed that the typical peaks at 3.1-3.9 ppm were assigned to the glucosamine unit (H3, H4, H5, and H6) of chitosan, that at 2.97 ppm corresponds to H2 and that at 4.5 ppm is related to the methyl protons of the N-acetyl group. 54 In the spectrum of CSGH, the typical peak of H2 is at 3.06 ppm and the peak shape becomes lower, which demonstrates the existence of biguanide groups in CSGH. The results were in consistent with our previous research.…”

Section: Characterization Of Chitosan and Csghmentioning

confidence: 95%

Microwave-assisted synthesis of chitosan biguanidine hydrochloride and its regulation on InsR and GLUT2 in insulin resistant HepG2 cells

et al. 2017

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“…The above advantages of the system make it highly promising as a source of new biomedical sterilization materials. In another study, a membrane was prepared from a mixture of gelatin, PVP, and a hydroxypropyl chitosan biguanide chloride copolymer [ 109 ]. The membrane showed good iodine absorption and sustained iodine release at lower temperatures.…”

Section: Applications Of Polymeric Iodophorsmentioning

confidence: 99%

Polymeric Iodophors: Preparation, Properties, and Biomedical Applications

2020

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The review summarizes the data on the main chemical and physiological properties of iodine and its capability of complexation with natural and synthetic polymers. Iodine is the best known antiseptic used to prevent and treat microbial infections. Its unique capability of complexation with certain polymers opens wide opportunities for targeted and prolonged delivery to target organs. Polymeric complexes with iodine have another color, other morphology, a higher electrical conductivity, and higher biological activity as compared with initial polymers. The formation of and ions is associated with iodine–polymer complexation. Iodine-containing biocompatible adhesive controlled-release formulations are designed as part of research into iodine–polymer complexes. The field is promising in terms of treating certain diseases because tolerance to iodine compounds does not usually develop in microbial cells.

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Preparation and antibacterial activity of chitosan derivative membrane complexation with iodine

Abstract: A chitosan based material with a polyvinylpyrrolidone membrane was prepared and used to adsorb iodine. The resultant material exhibited the sustained-release of iodine, and significant antibacterial activity against E. coli and S. aureus.

Cited by 22 publications

References 48 publications

A Portable Device for the Generation of Drug-Loaded Three-Compartmental Fibers Containing Metronidazole and Iodine for Topical Application

A Portable Device for the Generation of Drug-Loaded Three-Compartmental Fibers Containing Metronidazole and Iodine for Topical Application

Microwave-assisted synthesis of chitosan biguanidine hydrochloride and its regulation on InsR and GLUT2 in insulin resistant HepG2 cells

Polymeric Iodophors: Preparation, Properties, and Biomedical Applications

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