Preparation and characterization of amino–silane modified superparamagnetic silica nanospheres

Liu, Xianqiao; Ma, Zhi-Ya; Jian-wei, Xing; Liu, Huizhou

doi:10.1016/j.jmmm.2003.07.006

Cited by 497 publications

(138 citation statements)

References 14 publications

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“…The co-precipitation method was used for the synthesis of Fe 3 O 4 nanoparticles [16]. In the typical experimental procedure, 8.11 g of iron (III) chloride hexahydrate (FeCl 3 •6H 2 O), 5.96 g of iron (II) chloride tetrahydrate (FeCl 2 •4H 2 O) were added into three-necked flask contains 200 mL deionized water previously heated to 85˚C.…”

Section: Preparation Of Fe 3 O 4 Nanoparticles (Mnps)mentioning

confidence: 99%

Synthesis and Characterization of Fe3O4 Coated on APTES as Carriers for Morin-Anticancer Drug

Saif¹,

Wang²,

Dong³

et al. 2015

JBNB

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Morin (MR) is an anticancer drug present in fruits and Chinese herbs. Fe 3 O 4 magnetic nanoparticles (MNPs) coated on 3-aminopropyl triethoxysilane (APTES) were synthesized (MNPs-APTES) as carriers for MR. The characterization of drug delivery system was confirmed by Fourier Transform Infrared (FTIR), Transmission Electron Microscope (TEM), X-Ray Diffraction (XRD), dynamic light scattering (DLS), and vibrating sample magnetometer (VSM). The adsorbed APTES on the magnetite surface (MNPs-APTES) was examined by FTIR. The TEM image showed that the average particle size is obtained to be about 26.7 nm for MNPs-APTES. The MR loading and release behavior of MNPs-APTES were studied and the results showed that up to 60% of the adsorbed drug was released within 4 h. In summary, the MNPs-APTES nanocarriers are based on the results, promising for targeted morin drug delivery.

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Section: Preparation Of Fe 3 O 4 Nanoparticles (Mnps)mentioning

confidence: 99%

Synthesis and Characterization of Fe3O4 Coated on APTES as Carriers for Morin-Anticancer Drug

Saif¹,

Wang²,

Dong³

et al. 2015

JBNB

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“…As shown in Figure 3, the pristidin magnetic nanoparticles had a mean diameter of 29 nm. Using the ultrasonic processor caused smaller and more homogenized magnetic nanoparticles prepared [66]. After modification process, the modified magnetic nanoparticles prepared are in the range of 58-73 nm in diameter.…”

Section: Characteristics Of Modified Magnetic Nanoparticlesmentioning

confidence: 99%

Preconcentration and Determination of Ciprofloxacin with Solid-phase Microextraction and Silica-coated Magnetic Nanoparticles Modified with Salicylic Acid by UV-Vis Spectrophotometry

Neshin¹,

Ebrahimi²

2018

Eurasian J Anal Chem

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In the present age, the pharmaceutical application continues to increase and this results in the environmental pollution. As a result, pharmaceutical control is a common technique in many labs. This project is on the improvement of the procedure to determine a small amount of ciprofloxacin (CF) in bio-environmental sample. Regarding the fact that each method requires preliminary measures to preconcentrate and prepare analyte prior to measurement and recognition. In recent study, preconcentration of samples containing CF (as antibiotic) based on solid-phase microextraction method using silica-coated magnetic nanoparticles modified with salicylic acid (SA) was proposed which acted as sorbent. In addition, UV-Vis spectrophotometry was carried out to determine the amount of CF. The wavelength of maximum absorption (λmax) for this drug was 275 nm. Also, the optimum conditions of various parameters such as pH of solution, amount of magnetic nanoparticles, time, the effect of stirring speed on the extraction and desorption, the rate of centrifugation, the volume of aqueous and organic-phases, temperature and salt effect were investigated. The dynamic range was obtained between 0.05-0.15 mg L -1 , LOD and RSD (%) were 0.002 mg L -1 and 1.878 respectively. Results showed using this procedure increased the concentration factor to 68.36. Relative recovery was achieved by spike method.

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“…Superparamagnetic nanoparticles (Fe 3 O 4 ) were obtained using the method reported by Stroeve et al 25 The particle surface was then transformed into SiO 2 shell by a sol-gel process, 26 using tetraethyl orthosilicate. The product obtained was suspended in absolute ethanol containing ammonia solution.…”

Section: Generation Of Dmpmentioning

confidence: 99%

Immobilized transferrin Fe3O4@SiO2 nanoparticle with high doxorubicin loading for dual-targeted tumor drug delivery

Ding

Guo

2013

IJN

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Transferrin (Tf) was immobilized onto Fe 3 O 4 @SiO 2 nanoparticles with high doxorubicin (DOX) loading (TfDMP), for dual targeting of cancer, by chemically coupling both Tf and DOX with dual-function magnetic nanoparticles (DMPs) using a multi-armed crosslinker, poly-L-glutamic acid. With high trapping efficiency for magnetic targeting, TfDMP exhibits a Tf receptor-targeting function. Moreover, the DOX loading percentage of TfDMP is high, and can be controlled by adjusting the reactant ratio. TfDMP presents a narrow size distribution, and is sensitive to pH for drug release. Compared with DOX-coupled DMP without Tf modification (DDMP), TfDMP exhibits enhanced uptake by Tf receptor-expressing tumor cells, and displays stronger cancer cell cytotoxicity. This study provides an efficient method for the dual-targeted delivery of therapeutic agents to tumors, with controlled low carrier toxicity and high efficiency.

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Preparation and characterization of amino–silane modified superparamagnetic silica nanospheres

Cited by 497 publications

References 14 publications

Synthesis and Characterization of Fe<sub>3</sub>O<sub>4</sub> Coated on APTES as Carriers for Morin-Anticancer Drug

Synthesis and Characterization of Fe<sub>3</sub>O<sub>4</sub> Coated on APTES as Carriers for Morin-Anticancer Drug

Preconcentration and Determination of Ciprofloxacin with Solid-phase Microextraction and Silica-coated Magnetic Nanoparticles Modified with Salicylic Acid by UV-Vis Spectrophotometry

Immobilized transferrin Fe3O4@SiO2 nanoparticle with high doxorubicin loading for dual-targeted tumor drug delivery

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Preparation and characterization of amino–silane modified superparamagnetic silica nanospheres

Cited by 497 publications

References 14 publications

Synthesis and Characterization of Fe&lt;sub&gt;3&lt;/sub&gt;O&lt;sub&gt;4&lt;/sub&gt; Coated on APTES as Carriers for Morin-Anticancer Drug

Synthesis and Characterization of Fe&lt;sub&gt;3&lt;/sub&gt;O&lt;sub&gt;4&lt;/sub&gt; Coated on APTES as Carriers for Morin-Anticancer Drug

Preconcentration and Determination of Ciprofloxacin with Solid-phase Microextraction and Silica-coated Magnetic Nanoparticles Modified with Salicylic Acid by UV-Vis Spectrophotometry

Immobilized transferrin Fe3O4@SiO2 nanoparticle with high doxorubicin loading for dual-targeted tumor drug delivery

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Synthesis and Characterization of Fe<sub>3</sub>O<sub>4</sub> Coated on APTES as Carriers for Morin-Anticancer Drug

Synthesis and Characterization of Fe<sub>3</sub>O<sub>4</sub> Coated on APTES as Carriers for Morin-Anticancer Drug