Preparation and characterization of doxorubicin functionalized gold nanoparticles

Mirza, Agha Zeeshan; Shamshad, Hina

doi:10.1016/j.ejmech.2011.02.048

Cited by 94 publications

(54 citation statements)

References 30 publications

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“…Au colloid monolayers possess a set of features that make them very attractive for both basic and applied uses, including uniform roughness, high stability, and biocompatibility [19]. Recently Mirza and Shamshad [20] investigated the gold nanoparticles (Au NPs) functionalized with an anticancer drug, doxorubicin. Their study laid the basis of a linking methodology via hybrid multi drug, and receptor labelled NPs might be developed, which may provide an alternative design for nanosized drug-delivery system.…”

Section: Physical Synthesismentioning

confidence: 99%

Biogenic Synthesis of Nanoparticles and Potential Applications: An Eco- Friendly Approach

Ingale¹

2013

J Nanomedic Nanotechnol

252

114

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The uprising in materials science has been hosted by previous few decades. There has been a substantial research interest in the area of using particulate systems to accomplish various approaches. The conception or synthesis of material with nanometer-scale precision (nanoparticles), by means of material science, is nanotechnology. Nanoparticles are defined as particulate dispersal or solid particles, with a size in the range of 1-100 nm.This review intends to present biosynthesis and application of nanoparticles in minutiae. Here, we discussed different synthesis methods, i.e. chemical, physical and biogenic synthesis of nanoparticles. The potential come together between nanotechnology and biological science is enormous. Realistic biologics depends on units that have nanoscale dimensions (proteins, viruses, molecular motors, extra cellular matrix). Our major dictum is to focus the various facet of synthesis of nanoparticles, characterization, and its imperative application by giving accent on biogenic synthesis of nanoparticles.

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Section: Physical Synthesismentioning

confidence: 99%

Biogenic Synthesis of Nanoparticles and Potential Applications: An Eco- Friendly Approach

Ingale¹

2013

J Nanomedic Nanotechnol

252

114

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“…Venkatpurwar et al [16] reported attachment of doxorubicin with porphyran reduced AuNPs by electrostatic interaction. Mirza et al [17] also reported direct conjugation of doxorubicin by electrostatic binding of protonated amine group of doxorubicin with negatively charged citrate-reduced AuNPs.…”

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confidence: 99%

Preparation and Characterization of Ganciclovir Loaded Glutathione Modified Gold Nanoparticles

Kiroula¹,

Negi²

2016

pharmaceutical-sciences

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Kiroula, et al.: Glutathione-modified Gold Nanoparticles of GanciclovirThis article reports that ganciclovir-loaded gold nanoparticles were developed via glutathione surface modification. Citrate-reduced gold nanoparticles were prepared first from chloroauric acid. Further the surface of gold nanoparticles was modified with glutathione. Then ganciclovir was loaded onto the glutathione-modified gold nanoparticles through the reaction between carboxyl group of glutathione and amino group of ganciclovir. Gold nanoparticles were characterized by photon correlation spectroscopy, transmission electron microscopy and infrared spectroscopy. Drug loading of 87.27±2.52% was observed for ganciclovir-loaded gold nanoparticles. The particle size distribution of gold nanoparticles ranged from 26.3 to 31 nm. Thus ganciclovir-loaded gold nanoparticles were successfully prepared, which might further improve the oral bioavailability of ganciclovir.

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“…And now as it is being synthesized with appropriate size scale and desired structures, it is getting much more enthusiasm such as biomedical applications particularly in targeted drug delivery therapy by one step approach. The multifunctional doxorubicin (DOX) conjugated AuNPs (DOX-AuNPs) may also be used to improve imaging contrast for photothermal cancer therapy 24 . Up to now DOX (figure 1) has been considered as an effective anticancer drug and its activity is apparently related to the direct interactions with dsDNA 25,26 , Therefore DOX is an inhibitor of the topoisomerase II and can inhibit DNA duplication and transcription to mRNA 27 .…”

Section: Introductionmentioning

confidence: 99%

Polyethylene glycol gold-nanoparticles: Facile nanostructuration of doxorubicin and its complex with DNA molecules for SERS detection

Spadavecchia

Perumal

Casale

et al. 2016

Chemical Physics Letters

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We report the synthesis of dicarboxylic acid-terminated polyethylene-glycol (PEG)-gold nanoparticles by a simple one-step method, and their further use to form nanostructured surfaces for biomolecule immobilization. The synthesized nano-scale particles were conjugated with probe/target oligonucleotides in order to evaluate intercalation phenomenon in the presence of doxorubicin drug via Surface Enhanced Raman Spectroscopy (SERS) analysis.

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Preparation and characterization of doxorubicin functionalized gold nanoparticles

Cited by 94 publications

References 30 publications

Biogenic Synthesis of Nanoparticles and Potential Applications: An Eco- Friendly Approach

Biogenic Synthesis of Nanoparticles and Potential Applications: An Eco- Friendly Approach

Preparation and Characterization of Ganciclovir Loaded Glutathione Modified Gold Nanoparticles

Polyethylene glycol gold-nanoparticles: Facile nanostructuration of doxorubicin and its complex with DNA molecules for SERS detection

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