Preparation and characterization of electrospun polycaprolactone/polyethylene oxide membranes

Nien, Yu–Hsun; Shih, Chung‐Yang; Yang, Chih‐Yuan; Lu, Chien-Ju; Ye, Quan-Xun

doi:10.1007/s10965-013-0166-9

Cited by 15 publications

(4 citation statements)

References 16 publications

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“…2). The C O stretching intensity of PCL at 1725/cm decreased with increasing PEG composition [29], whereas C O C stretching intensity of PEG at 1107/cm increased with increasing PEG composition [30,31]. This confirmed the homogeneous blending of PEG and PCL in the electrospun NFMs.…”

Section: Preparation and Characterization Of Electrospun Nfmsupporting

confidence: 57%

Prevention of peritendinous adhesions with electrospun polyethylene glycol/polycaprolactone nanofibrous membranes

Chen

Shalumon

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Section: Preparation and Characterization Of Electrospun Nfmsupporting

confidence: 57%

Prevention of peritendinous adhesions with electrospun polyethylene glycol/polycaprolactone nanofibrous membranes

Chen

Shalumon

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…Jackson, et al showed the addition of water soluble molecules, such as sodium chloride, dextran or PEO, to PMMA bone cement monolithic blocks only caused minor changes in strength, but greatly enhanced the drug release profiles, such as vancomycin and linezolid 19 . In another study, the addition of PEO to drug loaded polycaprolactone implants enhanced drug release profiles as the PEO dissolved out of hydrophobic brittle polycaprolactone 20 . Whilst the insertion of PEO into cement is easy (simple mixing), electrospinning methods might be excessively compromised by the addition of large amounts of excipients.…”

Section: Discussionmentioning

confidence: 99%

Doxycycline release and antibacterial activity from PMMA/PEO electrospun fiber mats

et al. 2019

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Objective:To investigate the use of polymethyl methacrylate (PMMA) electrospun fiber mats containing different amounts of polyethylene oxide (PEO) as a doxycycline delivery system and to test antibacterial activity against an oral pathogen.Methodology:PMMA powders or PEO (mol wt 200 Kd) (10,20,30% w/w/) were dissolved in N, N-dimethylformamide (DMF) to obtain a final polymer concentration of 15% in DMF (w/v). 2% Doxycycline monohydrate was added to the solutions and submitted to vortex mixing. The solution was transferred to a plastic syringe and fit into a nanofiber electrospinning unit. The parameters applied were: voltage at 17.2 kV; distance of 20 cm between the needle tip and the collector plate; target speed at 2 m/min; and transverse speed at 1cm/min. Syringe pump speed was 0.15 mm/min. The drug release analysis was performed by removing aliquots of the drug-containing solution (in PBS) at specific periods. Doxycycline release was quantified using RP-HPLC. Fiber mats from all groups had their antibacterial action tested against S. mutans based on inhibition halos formed around the specimens. The experiments were performed in triplicate. Gravimetric analysis at specific periods was performed to determine any polymer loss. Morphological characterization of the electrospun fibers was completed under an optical microscope followed by SEM analysis.Results:The addition of PEO to the PMMA fibers did not affect the appearance and diameter of fibers. However, increasing the %PEO caused higher doxycycline release in the first 24 h. Fibers containing 30% PEO showed statistically significant higher release when compared with the other groups. Doxycycline released from the fibers containing 20% or 30% of PEO showed effective against S. mutans.Conclusion:The incorporation of PEO at 20% and 30% into PMMA fiber mat resulted in effective drug release systems, with detected antibacterial activity against S. mutans.

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“…In this regard, embedding therapeutic substances into electrospun dressings followed by their subsequent release would open up new applicative biomedicine solutions to treat pains and diseases. Most promising investigations have demonstrated the incorporation and subsequent release from electrospun matrices of nonsteroidal anti‐inflammatory drugs (NSAIDs) such as ibuprofen (IBU) , ketoprofen (KET) , indomethacin , diclofenac , and meloxicam . Other electrospinning studies have been focused on the encapsulation of analgesic compounds such as paracetamol and acetylsalicylic acid (aspirin) .…”

Section: Drug Release From Electrospun Matricesmentioning

confidence: 99%

A review on electrospun polymer nanostructures as advanced bioactive platforms

2016

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This review article deals with latest literature studies on the potential use of polymer ultrathin and nanosized structures obtained by electrospinning to design novel engineered materials with bioactive properties. The electrofluidodynamic process offers the option to form high-performance bioactive systems based on polymer yarns of nanofibers or coatings of nanobeads with high surface-to-volume ratios. The electrospun and electrosprayed nanostructures can be further functionalized by encapsulation with bioactive fillers and substances. For both scenarios, the resultant polymer nanostructures present unique bioactive properties capable of providing a beneficial impact over human's health and with improved and advanced performance for biomedicine, pharmaceutics, nutrition, bioengineering, and healthcare applications. These novel functional materials attained by the electrospinning technology can be of interest for many bioactive applications such as functional food design, food packaging, functional coatings, controlled delivery of drug solutions and, mainly, tissue engineering. This article is purposely designed to gather, for the first time, most recent and promising multi-and inter-disciplinary develop-

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Preparation and characterization of electrospun polycaprolactone/polyethylene oxide membranes

Cited by 15 publications

References 16 publications

Prevention of peritendinous adhesions with electrospun polyethylene glycol/polycaprolactone nanofibrous membranes

Prevention of peritendinous adhesions with electrospun polyethylene glycol/polycaprolactone nanofibrous membranes

Doxycycline release and antibacterial activity from PMMA/PEO electrospun fiber mats

A review on electrospun polymer nanostructures as advanced bioactive platforms

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