Preparation and characterization of insulin nanoparticles using chitosan and Arabic gum with ionic gelation method

Avadi, Mohammad Reza; Sadeghi, A.M.M.; Mohammadpour, Nasser; Abedin, Saideh; Atyabi, Fatemeh; Dinarvand, Rassoul; Rafiee-Tehrani, Morteza

doi:10.1016/j.nano.2009.04.007

Cited by 328 publications

(188 citation statements)

References 22 publications

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“…On the contrary, negative zeta potential values seem to propitiate aggregation. It is known that positive zeta potential keeps a thicker double-layer that appears to prevent aggregation [35]. …”

Section: Zeta Potential Of Hydrogelsmentioning

confidence: 99%

Polyelectrolyte Complexation versus Ionotropic Gelation for Chitosan-Based Hydrogels with Carboxymethylcellulose, Carboxymethyl Starch, and Alginic Acid

Henao

Delgado

Contreras

et al. 2018

International Journal of Chemical Engineering

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e preparation of gels by charge interaction methods has been extensively studied, but it is not yet clear how these methods influence gel characteristics. e objective of this work was to study differences in morphology and surface charge of hydrogels prepared by ionotropic gelation, polyelectrolyte complexation, and a combination of both methods. us, the anionic charge was provided by carboxymethylcellulose (CMC), carboxymethylated starch (CMS), and alginic acid (AA); calcium chloride (CaCl 2 ) and chitosan (CS) were used for the ionotropic gelation and polyelectrolyte complexation, respectively. ose materials are commercially available, have low toxicity, and are widely used in the area. ese compounds interact through physical crosslinks, which are affected by physical changes of the medium. Our results showed that these two methods produced changes in the morphology of the hydrogels. CMC gels exhibited larger pores in the presence of CaCl 2 . In polyelectrolyte complexation, CMS produced an increased agglomeration of particles, while the addition of CaCl 2 to AA generated dispersed particles of size in the order of millimeters. Mixing both ionotropic gelation and polyelectrolyte complexation methods yielded gels of varied charge (568 mV for CMC, 502 mV for CMS, and 1713 mV for AA). FTIR spectra of the hydrogels showed interactions between the different polymeric compounds, being the greatest changes between 1250 and 1600 cm −1 , due possibly to the replacement of Na by Ca at crosslinking points. erefore, the method of gel preparation employed had a major influence on the size and pore distribution, parameters which in turn influence encapsulation and drug delivery in these systems.

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Section: Zeta Potential Of Hydrogelsmentioning

confidence: 99%

Polyelectrolyte Complexation versus Ionotropic Gelation for Chitosan-Based Hydrogels with Carboxymethylcellulose, Carboxymethyl Starch, and Alginic Acid

Henao

Delgado

Contreras

et al. 2018

International Journal of Chemical Engineering

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“…Nilai indeks polidispersitas yang mendekati nol menunjukkan distribusi partikel yang homogen atau seragam sedangkan nilai indeks polidispersitas yang melebihi 0,5 menunjukkan partikel memiliki tingkat heterogenitas yang tinggi. Nilai indeks polidispers pada tabel 3 tidak melebihi 0,5 sehingga menunjukkan bahwa seluruh formula nanopartikel yang dihasilkan memiliki distribusi ukuran partikel yang homogen sehingga memiliki kecendrungan stabil secara fisik sehingga tidak menyebabkan partikel saling beragregasi (Avadi 2010;Rahmawanty, 2014).…”

Section: Optimasi Lama Pengadukanunclassified

OPTIMIZATION OF STIRRING SPEED AND STIRRING TIME TOWARD NANOPARTICLE SIZE OF CHITOSAN-SIAM CITRUS PEEL (Citrus nobilis L.var Microcarpa) 70% ETHANOL EXTRACT

et al. 2017

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“…The average zeta potential was positive for the different nanosystem formulations, which is attributed to the residual amine groups of Ch that neutralize the negative charges of GA and PEGAuNPs. Also, the strong positive charges on the surface of nanoparticles prevent the aggregation (Table 1) Avadi et al 2010;Avadi et al 2011). The release profiles of BTZ from Ch-GA NPs and Ch-GA-PEGAuNPs were performed in vitro using a dialysis membrane in PBS 0.01 M at 37 ºC.…”

Section: Methodsmentioning

confidence: 99%

Encapsulation of a proteasome inhibitor with gold-polysaccharide nanocarriers

et al. 2014

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Designing positively charged chitosan-gum arabic-gold nanoparticle structures is farsighted to be a new approach to specific drug delivery. To reconnoitre this concept, an anticancer drug activity was evaluated with a proteasome inhibitor, bortezomib, in pancreatic cell lines, S2-013 and hTERT-HPNE. Laser scanning confocal microscopy show the uptake of the gold nanoparticle/bortezomib encapsulated in chitosan-gum arabic matrix and the fast internalization of these nanocombinations into pancreatic cells. Cytotoxic assays assessed that positively charged nanosystems reduce the cell growth and cell proliferation of S2-013s but the same effect was not observed in cytotoxic response in hTERT-HPNE cells. The findings of this study show the capacity of chitosan-gum arabic nanocarriers to deliver gold nanoparticles/anticancer drug and to increase the permeation and retention effect in S2-013 cells and minimize drug side effects in HPNE cells.

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Preparation and characterization of insulin nanoparticles using chitosan and Arabic gum with ionic gelation method

Cited by 328 publications

References 22 publications

Polyelectrolyte Complexation versus Ionotropic Gelation for Chitosan-Based Hydrogels with Carboxymethylcellulose, Carboxymethyl Starch, and Alginic Acid

Polyelectrolyte Complexation versus Ionotropic Gelation for Chitosan-Based Hydrogels with Carboxymethylcellulose, Carboxymethyl Starch, and Alginic Acid

OPTIMIZATION OF STIRRING SPEED AND STIRRING TIME TOWARD NANOPARTICLE SIZE OF CHITOSAN-SIAM CITRUS PEEL (Citrus nobilis L.var Microcarpa) 70% ETHANOL EXTRACT

Encapsulation of a proteasome inhibitor with gold-polysaccharide nanocarriers

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