Preparation and characterization of ketoprofen-loaded solid lipid nanoparticles made from beeswax and carnauba wax

Kheradmandnia, Soheila; Vasheghani‐Farahani, Ebrahim; Nosrati, Masoud; Atyabi, Fatemeh

doi:10.1016/j.nano.2010.06.003

Cited by 237 publications

(141 citation statements)

References 28 publications

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“…This endothermic event corresponds to melting of the drugs. The melting point of raw-NSAIDs matched well with the data that is reported in the literature [62][63][64]. The nanoformulated NSAIDs also had somewhat similar melting points as the rawNSAIDs.…”

Section: Thermal Characteristicssupporting

confidence: 84%

Unusual anti-leukemia activity of nanoformulated naproxen and other non-steroidal anti-inflammatory drugs

Kumar

Siril

Javid

2016

Materials Science and Engineering: C

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The non-steroidal anti-inflammatory drugs (NSAIDs) are the most widely used pharmaceuticals worldwide. Interestingly, many of them have significant anticancer properties too. However, the poor water solubility of certain NSAIDs limits their application for cancer treatment. Nanosizing of such drugs can help to improve the solubility and this may result in enhanced anticancer activities too. Moreover, over dosages and the accompanying side effects of NSAIDs can be minimized by improving their solubility and bioavailability. Successful nanoformulation of three NSAIDs: ibuprofen (IBP), ketoprufen (KP) and naproxen (NAP) using a novel evaporation assisted solvent-antisolvent interaction (EASAI) method is reported here. Three water soluble and biocompatible polymers: polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA) and hydroxypropyl methylcellulose (HPMC) were used to stabilize the drug nanoparticles. Particles having spherical morphology with average size below 30 nm were thoroughly characterized using dynamic light scattering and field emission scanning electron microscopy (FESEM) imaging. The nanoformulation resulted in ten to fifteen fold improvements in the solubility and significant enhancement in the in-vitro drug release profiles of the NSAIDs. Anticancer screening of the nanoformulated NSAIDs against five different cancer cell lines such as MCF-7 (Human breast cancer cell line), (Human pancreatic cancer cell line) MIA-PA-CA-2, (Human colon cancer cell line) HT-29, (Human leukemia cell line) Jurkat and (human ovarian carcinoma cell line) A2780 was performed. All the nanoformulated samples showed improved anticancer activity against the Leukemia cancer cell line, out of which NAP-PVP showed the highest anti-cancer activity. The anti-Leukemia activity of NAP-PVP was more than twice that of doxorubicin which is a standard anticancer drug.

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Section: Thermal Characteristicssupporting

confidence: 84%

Unusual anti-leukemia activity of nanoformulated naproxen and other non-steroidal anti-inflammatory drugs

Kumar

Siril

Javid

2016

Materials Science and Engineering: C

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“…Differential scanning calorimetry thermograms and high-performance liquid chromatographic analysis indicated the stability of nanoparticles with negligible Microgranules drug leakage after 45 days of storage. It was also found that nanoparticles with more beeswax content in their core exhibited faster drug release as compared with those containing more carnauba wax in their structure [102] . Martins et al carried out the development and validation of a simple reversed-phase HPLC method for the determination of camptothecin in animal organs following administration in SLNs and concluded that the the method developed is reliable, precise and accurate and can be used in the determination of CPT amount in rat organ samples after i.v., administration of camptothecin in suspension, in physical mixture with SLN and incorporated in SLN [103] .…”

Section: Recent Advances Of Bioenhancersmentioning

confidence: 96%

Bioavailability enhancers of herbal origin: An overview

Kesarwani

Gupta

2013

Asian Pacific Journal of Tropical Biomedicine

397

197

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“…12,13 SLNs present some advantages in comparison to conventional carrier systems such as low toxicity, efficient incorporation of hydrophobic bioactive compounds in their lipid core, the ability to influence the release profile of their cargo from the solid matrix and easy large-scale production. 14,15 Several methods are employed in the SLNs preparation, however the method of emulsification-solvent evaporation is usually applied when the bioactive compound has low solubility in the lipid or it is thermosensitive. 16,17 The common lipids used to obtain the SLNs are triglycerides, 12 fatty acids 13 and waxes.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Evaluation of Novel Triglyceride-Based Nanocomposites for Biomedical Applications

Almeida¹,

Gallo²,

Silva³

et al. 2017

J. Braz. Chem. Soc.

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This work describes the development and characterization of triglyceride-based magnetic nanocomposites for application in magnetic hyperthermia and controlled drug delivery. The magnetic solid lipid nanocomposites (MSLN) constituted by mixtures of trilaurin-tricaprylin and trilaurin-tricaprin have been successfully obtained by emulsification-solvent evaporation method. The developed MSLNs were subjected to an external oscillating magnetic field and showed significant hyperthermia. The samples were exposed to frequencies of 688 and 869 kHz causing, respectively, a temperature increase of 15.5 and 22.7 °C (trilaurin-tricaprylin) and 17.3 and 26.1 °C (trilaurin-tricaprin). Also, in vitro assays in the absence of magnetic field showed that the triglyceride-based formulations were able first to encapsulate and then to sustained release an antitumoural hydrophobic drug. After 72 h of assay trilaurin-tricaprylin and trilaurin-tricaprin released 73 and 55% of their cargo, respectively. In addition, MSLN exhibited low in vitro cytotoxic activity against human neutrophils.Keywords: lipid mixture, magnetic hyperthermia, drug delivery, oncocalyxone-A IntroductionNanotechnology is an expanding sector and the use of superparamagnetic iron oxide nanoparticles (SPIONs) is attracting increasing attention in several areas. SPIONs are widely employed for biotechnological applications through the development of magnetic systems for use in: cell separation, as contrast agents for magnetic resonance imaging (MRI), magnetic hyperthermia, targeted bioactive compounds delivery and biosensors. [1][2][3][4] Such applications explore the biggest advantages of using SPIONs: biocompatibility and satisfactory magnetic response at applied magnetic field (superparamagnetic character). 5,6 The surface of the magnetic nanoparticles should be modified, not only in order to prevent oxidation and aggregation, but also to provide colloidal stability, reduced magnetic susceptibility, as well as to expand the effectiveness of cellular uptake and biodistribution. The hydroxyl groups present on the surface of nanoparticles can function as an anchor point for various types of compounds such as oleic acid, which is commonly used in the synthesis of magnetic ferrofluids. The criteria adopted to select the appropriate coating of magnetic nanoparticles depends mainly on the intended application. In the case of this research, magnetic nanoparticles made of iron oxide were coated with oleic acid (Fe 3 O 4 @OA) for subsequent incorporation into lipid carriers. 7-9The lipid carriers have been widely used as they also possess excellent characteristics such as biocompatibility Preliminary Evaluation of Novel Triglyceride-Based Nanocomposites for Biomedical Applications J. Braz. Chem. Soc. 1548 and versatility, and they have been proposed for the delivery of bioactive compounds by oral, intravenous, topical and parenteral routes. 10,11The solid lipid nanoparticles (SLNs) emerged in the early 90's and currently are alternative encapsulation systems and carriers o...

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Preparation and characterization of ketoprofen-loaded solid lipid nanoparticles made from beeswax and carnauba wax

Cited by 237 publications

References 28 publications

Unusual anti-leukemia activity of nanoformulated naproxen and other non-steroidal anti-inflammatory drugs

Unusual anti-leukemia activity of nanoformulated naproxen and other non-steroidal anti-inflammatory drugs

Bioavailability enhancers of herbal origin: An overview

Preliminary Evaluation of Novel Triglyceride-Based Nanocomposites for Biomedical Applications

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