Preparation and characterization of nanoemulsions of curcumin and echium oil

İnal, Aslı; Yenipazar, Hande; Şahin‐Yeşilçubuk, Neşe

doi:10.1016/j.heliyon.2022.e08974

Cited by 15 publications

(3 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of the optimized compositions, pC-NEU, led to a nanoemulsion with small hydrodynamic size (<200 nm), narrow size distribution (PDI<0.150) and high positive zeta potential (+40mV) which showed good stability profiles at different conditions of pH and temperature, and also after scaling up the synthesis process, which is highly desirable from a pharmaceutical industry point of view, ensuring an easier translation process [45]. Moreover, pC-NEU showed high entrapment capacity of L-palmitoyl carnitine, corroborating our initial hypothesis of the potential of nanoemulsions, if properly designed, as a drug delivery system for hydrophobic active compounds [46][47][48]. The biodistribution profile obtained is in line with those found by other authors for nanoemulsion with similar size [43,44], but it could be modulated changing physicochemical properties of the nanocarriers, such as size and surface composition [49].…”

Section: Discussionsupporting

confidence: 72%

A quality by design approach for the synthesis of palmitoyl carnitine loaded nanoemulsions as drug delivery systems

Urea

Hernando

Barriga

et al. 2022

Preprint

View full text Add to dashboard Cite

Nanoemulsions (NE) are lipid nanocarriers that can efficiently load hydrophobic active compounds, like palmitoyl-L-carnitine (pC), used here as model molecule. The use of design of experiments (DoE) approach is a useful tool to develop NE with optimized properties, requiring less experiments compared to trial-and-error approach. The optimized formulation was studied for its stability, scalability, pC entrapment, loading capacity, and biodistribution in mice. NE were prepared by the solvent injection technique. DoE was implemented for designing pC-loaded NE, using a two-level fractional factorial design as model. NE were fully characterized by a combination of techniques, and biodistribution was studied ex-vivo after injection of fluorescent NE in healthy mice. We selected the optimal formulation of NE, named pC-NEU, after DoE analysis of four variables. pC-NEU incorporated pC in a very efficient manner, with high entrapment efficiency and loading capacity. pC-NEU did not change its initial colloidal properties stored at 4ºC in water during 120 days, nor in buffers with different pH values (5.3 and 7.4) during 30 days. The scalability process did not affect NE stability properties. Biodistribution study showed that pC-NEU formulation was predominantly concentrated in the liver, with minimal accumulation in spleen, stomach and kidneys.

show abstract

Section: Discussionsupporting

confidence: 72%

A quality by design approach for the synthesis of palmitoyl carnitine loaded nanoemulsions as drug delivery systems

Urea

Hernando

Barriga

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…[7][8][9] In all these lipid-based nanocarriers, the solubilization performance of poorly water-soluble drugs is improved due to their increased surface areas, which leads to enhancing their oral bioavailability. [10][11][12][13] A revolutionary change has been noticed since the implementation of Quality by Design (QbD) as a mandatory requirement of the USFDA for the development of dosage forms to build quality into the product in the pharmaceutical industry. 4,14,15 Quality by a testing concept has disappeared after the implementation of the concept of QbD as quality is built into the product.…”

Section: Introductionmentioning

confidence: 99%

Design Expert-Implemented Nimodipine-Loaded Lyophilized Nanoemulsifying Drug Delivery System for Improved Oral Bioavailability and Physical Stability

Das,

Panda,

Jena

et al. 2024

Ind. J. Pharm. Edu. Res

View full text Add to dashboard Cite

To improve the oral bioavailability as well as the physical stability of nimodipine, Design-Expert-driven nimodipine loaded nanoemulsifying drug delivery system was developed with a certain quality target product profile. Materials and Methods: In this investigation, the three components triacetin as oil phase, labrasol as a surfactant, and plurol oleique CC 497 as co-surfactant were selected after screening. The ratio of surfactant and co-surfactant (S mix ) was selected from the pseudo-ternary phase diagram drawn by using ProSim ternary software. A d-optimal mixture design was employed to optimize the formulation. The dynamic light scattering, Fourier transform Infrared, Differential Scanning Calorimetry, X-ray Diffraction, Scanning Electron Microscopy, in vitro drug release, stability study, and in vivo pharmacokinetic studies were carried out for the characterization of the optimized formulation. Results: The globule size, PDI, and Zeta potential of the optimized formulation were found to be 322.1 nm, 0.48, and -14.5 mV respectively. The result of in vivo pharmacokinetic studies exhibited three-fold enhanced oral bioavailability of the optimized nanoemulsion as compared to the pure drug of nimodipine and the physical stability of the optimized nanoemulsion improved significantly as compared to the pure drug. Conclusion: The NIMO-loaded nanoemulsifying drug delivery system can be successfully fabricated by implementing the Design-Expert with improved oral bioavailability and physical stability significantly as compared to the pure drug of NIMO.

show abstract

“…which can signi cantly enhance solubility and bioavailability of poorly water-soluble drugs [8][9][10]. In all these lipid-based nanocarriers, the solubilization performance of poorly water-soluble drugs is improved due to their increased surface areas, which leads to enhancing their oral bioavailability [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Design Expert-implemented Nimodipine Nanoemulsion: Fabrication, Optimization, and Characterization for Improved Oral Bioavailability and Physical Stability

Das

Panda

Jena

et al. 2022

Preprint

View full text Add to dashboard Cite

Background The oral bioavailability and biological half-life (t1/2) of nimodipine(NIMO) are 13%(approximately) and 7-8h, respectively. The poor oral bioavailability and short t1/2 are due to extensive hepatic metabolism. Due to short t1/2, frequent drug administration is required, which leads to the patient being incompliant and inconvenient. In order to improve the oral bioavailability as well as the physical stability, quality by design(QbD)-driven NIMO nanoemulsion was developed with a certain quality target product profile (QTPP). .In this investigation, the three components triacetin as oil phase, labrasol as a surfactant, and plurol oleique CC 497 as co-surfactant were selected after screening. The ratio of surfactant and co-surfactant (Smix) was selected from the pseudo-ternary phase diagram drawn by using ProSim ternary software. A d-optimal mixture design was employed to optimize the formulation. The dynamic light scattering (DLS), FTIR, DSC, X-RD, SEM, in vitro drug release, stability study, and in vivo pharmacokinetic studies were carried out for the characterization of the optimized formulation. Results The globule size, PDI, and Zeta potential of the optimized formulation were found to be 322.1 nm, 0.48, and − 14.5 mV respectively. The result of in vivo pharmacokinetic studies exhibited three-fold enhanced oral bioavailability of the optimized nanoemulsion as compared to the pure drug of nimodipine and the physical stability of the optimized nanoemulsion improved significantly as compared to the pure drug. Conclusion The NIMO-loaded nanoemulsion can be successfully fabricated by implementing the QbD approach with improved oral bioavailability and physical stability significantly as compared to the pure drug of NIMO.

show abstract

Preparation and characterization of nanoemulsions of curcumin and echium oil

Cited by 15 publications

References 44 publications

A quality by design approach for the synthesis of palmitoyl carnitine loaded nanoemulsions as drug delivery systems

A quality by design approach for the synthesis of palmitoyl carnitine loaded nanoemulsions as drug delivery systems

Design Expert-Implemented Nimodipine-Loaded Lyophilized Nanoemulsifying Drug Delivery System for Improved Oral Bioavailability and Physical Stability

Design Expert-implemented Nimodipine Nanoemulsion: Fabrication, Optimization, and Characterization for Improved Oral Bioavailability and Physical Stability

Contact Info

Product

Resources

About