Preparation and characterization of near-infrared region absorption enhancer carbon nanotubes hybridmaterials

Huang, Peng; Zhang, Chunlei; Xu, Cheng; Bao, Le; Li, Zhiming

doi:10.5101/nbe.v2i4.p225-230

Cited by 13 publications

(9 citation statements)

References 29 publications

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“…Carbon-based nanomaterials, including fullerenes 15 , carbon nanotubes 16 - 17 , carbon nanohorns 18 , and their derivatives, exhibit great application prospects in PDT. For example, Fullerenes and their derivatives, due to their extended π-conjugation, have been reported as PSs in PDT 19 - 20 .…”

Section: Introductionmentioning

confidence: 99%

Folic Acid-conjugated Graphene Oxide loaded with Photosensitizers for Targeting Photodynamic Therapy

Huang¹,

Xu²,

Lin³

et al. 2011

Theranostics

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Photodynamic therapy (PDT) has emerged as an alternative and promising noninvasive treatment for cancer as well as non-cancer diseases, which involves the uptake of photosensitizers (PSs) by cancer cells followed by irradiation. The use of nanomaterials as carriers of PSs is a very promising approach to improve the development of PDT in clinical medicine. In this study, a novel folic acid-conjugated graphene oxide (GO) was strategically designed and prepared as targeting drug delivery system to achieve higher specificity. The second generation photosensitizer (PS) Chlorin e6 (Ce6) was effectively loaded into the system via hydrophobic interactions and π-π stacking. The nanocarriers can significantly increase the accumulation of Ce6 in tumor cells and lead to a remarkable photodynamic efficacy on MGC803 cells upon irradiation. These suggested that folic acid-conjugated GO loaded Ce6 had great potential as effective drug delivery system in targeting PDT.

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Section: Introductionmentioning

confidence: 99%

Folic Acid-conjugated Graphene Oxide loaded with Photosensitizers for Targeting Photodynamic Therapy

Huang¹,

Xu²,

Lin³

et al. 2011

Theranostics

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502

340

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“…Carbon nanotubes (CNTs) were discoveried in 1991 [1]. Since its discovery, CNTs' many unique properties such as mechanical, chemical and physical properties have been found gradually [2][3][4], CNTs have become highly attractive materials for applications in various fields including molecular electronics [5][6][7], field emission devices [8] and bioengineering [9,10]. So far many novel properties of CNTs have been being explored by attaching molecules outside [11,12] or encapsulating molecules inside CNTs [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Delivery of Gold Nanoparticles Inside Carbon Nanotubes by Oligonucleotides

Cui¹,

Ozkan²,

Tian³

et al. 2011

Nano BioMed ENG

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Delivery of gold nanoparticles with 2 nm or so in diameter inside multiwall carbon nanotubes (MCNTs) by oligonucleotides was performed under the condition of 400 k and 3 bar for 20 min. The Au-oligo-CNT complexes were first purified via 1% agarose gel electrophoresis and then analyzed via high resolution transmission electron microscopy (HR-TEM) and energy dispersive X-ray spectroscopy (EDX). The results showed that the excess of oligonucleotides, Au nanopartilces and the Au-oligo hybrids attached to the outside walls of CNTs could be removed away by agarose gel electrophoresis. HR-TEM and EDX results demonstrated that 2% or so Au-oligo hybrids were successfully delivered inside MCNTs. In contrast, few Au nanopartilces were observed to locate inside CNTs under identical experimental conditions. This is the very first confirmation that oligonucleotides can be used to deliver Au nanoparticles inside MCNTs. The van der Waals attraction between CNT and Au-oligo hybrids is likely the main driving force for this phenomenon. This phenomenon has potential applications in future nanotechnology such as molecular electronics, biochemical sensors, nano-devices, gene storage and delivery systems.

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“…Subsequently, 10 mL APTS were added to form a mixed solution and allowed to react under refluxing at 60 °C for 1 h. The resultant was washed with deionized water for five times and dried at 60 °C for 3 h in a vacuum oven to obtain the GNR-SiO 2 -NH 2 . The resultant was further coated with a polymer (PSS) by a layer-by-layer technique providing accessible amine groups to solvent [ 29 ]. These amine-terminated nanorods were allowed to react with the carboxylic acid of purified antibodies for 12–16 h in the presence of EDC, a water-soluble carbodiimide that promotes amide bond formation between the carboxylic acid and primary amine [ 30 ].…”

Section: Methodsmentioning

confidence: 99%

Antibody-Conjugated Silica-Modified Gold Nanorods for the Diagnosis and Photo-Thermal Therapy of Cryptococcus neoformans: an Experiment In Vitro

Xiao

Chen

et al. 2018

Nanoscale Res Lett

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BackgroundCryptococcus neoformans is an encapsulated yeast. There is still little quick and effective solution for the diagnosis or treatment of C. neoformans infection at an early stage in clinical. Antibody-conjugated silica-modified gold nanorods (GNR-SiO2-Ab) can conjugate C. neoformans selectively. It may provide a possibility for treatment of cryptococcosis safely and effectively.MethodsGold nanorods (GNRs) were synthesized according to the seed-mediated template-assisted protocol. Anti-C. neoformans antibody was covalently anchored on the surface of GNRs with silane coupling agent. In vitro computer tomography imaging was performed to explore the diagnostic effect of the GNR-SiO2-Ab. The viability of cells was evaluated to confirm the photo-thermal therapy effect of GNR-SiO2-Ab combined with near-infrared (NIR) laser light.ResultsGNR-SiO2-Ab has a potential application as a positive X-ray/CT imaging contrast agent. An antibody can induce a much greater aggregation of GNRs by binding to the surface of C. neoformans cells resulting in a much higher attenuation values than ever. After irradiation, C. neoformans cells suffered photo-thermal damages and the normal structure of cells were destroyed. The viability of cells reduced significantly compared to the untreated cells.ConclusionsOur work confirmed that antibody-conjugated silica-modified gold nanorods could enhance X-ray attenuation of C. neoformans cells in CT images. And immune GNRs, which were mediated by antibodies, could increase the effects of NIR-induced photo-thermal therapy in C. neoformans cells.

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Preparation and characterization of near-infrared region absorption enhancer carbon nanotubes hybridmaterials

Cited by 13 publications

References 29 publications

Folic Acid-conjugated Graphene Oxide loaded with Photosensitizers for Targeting Photodynamic Therapy

Folic Acid-conjugated Graphene Oxide loaded with Photosensitizers for Targeting Photodynamic Therapy

Delivery of Gold Nanoparticles Inside Carbon Nanotubes by Oligonucleotides

Antibody-Conjugated Silica-Modified Gold Nanorods for the Diagnosis and Photo-Thermal Therapy of Cryptococcus neoformans: an Experiment In Vitro

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