Preparation and Characterization of Paclitaxel/Chitosan Nanosuspensions for Drug Delivery System and Cytotoxicity Evaluation In Vitro

Liu, Yongjia; Wu, Fengren; Ding, Yongle; Zhu, Bangshang; Su, Yue; Zhu, Xinyuan

doi:10.1007/s42765-019-00012-z

Cited by 27 publications

(14 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Remarkably, for LPF-G, and LPF-S unexpected right-handed helical nanofibers obtained with the twist diameter of 120-150 nm and pitch falling in the range of 0.10-0.25 µm (Fig. 1b, c) [25]. LDAP assembled into right-handed twisted nanofibers with the twist diameter and pitch ranging from 200 to 300 nm and 1.0 to 1.1 µm, respectively (Fig.…”

Section: Sem Studiesmentioning

confidence: 86%

Chirality Transfer in Supramolecular Co-assembled Fibrous Material Enabling the Visual Recognition of Sucrose

et al. 2020

View full text Add to dashboard Cite

Molecular recognition of simple sugars is crucial due to their essential roles in most living organisms. However, it remains extremely challenging to achieve a visual recognition of simple sugars like sucrose in water media under physiological conditions. In this article, the visual recognition of sucrose is accomplished by a chiral supramolecular hydrogel formation through the co-assembly of a two-component fibrous solution (l-phenylalanine based gelator co-diaminopyridine, LDAP) and sucrose. H-bonding between the amino group of LDAP and the hydroxyl group of sucrose facilitates the gelation by loading sucrose into the LDAP solution. The formed hydrogel showed an amplified inversion of circular dichroism (CD) signals as compared to the corresponding LDAP solution. In addition, the effective chirality transfer was accompanied by a bathochromic shift in UV-Vis and FL spectra of the gel. Such a simple and straightforward chiral co-assembled strategy to visually recognize sucrose will have the potential use of smart gelators in saccharides separation and proteomics to be further applied in medical diagnostics and cell imaging.

show abstract

Section: Sem Studiesmentioning

confidence: 86%

Chirality Transfer in Supramolecular Co-assembled Fibrous Material Enabling the Visual Recognition of Sucrose

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Artificial nerve scaffolds hold great promise for the biomedical treatment of injured nerves by connecting the damaged stumps and new nerve tissues form within the scaffold chamber ( Liu et al, 2019 ; Jiang et al, 2020 ; Yan et al, 2020 ; Li et al, 2021 ). However, the functional restoration of PNIs still remains unsatisfactory ( Qian et al, 2018b ; Qian et al, 2019b ; Qian et al, 2019c ).…”

Section: Final Remarksmentioning

confidence: 99%

Two-Dimensional Nanomaterials for Peripheral Nerve Engineering: Recent Advances and Potential Mechanisms

Yan

Chen

Rosso

et al. 2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Peripheral nerve tissues possess the ability to regenerate within artificial nerve scaffolds, however, despite the advance of biomaterials that support nerve regeneration, the functional nerve recovery remains unsatisfactory. Importantly, the incorporation of two-dimensional nanomaterials has shown to significantly improve the therapeutic effect of conventional nerve scaffolds. In this review, we examine whether two-dimensional nanomaterials facilitate angiogenesis and thereby promote peripheral nerve regeneration. First, we summarize the major events occurring after peripheral nerve injury. Second, we discuss that the application of two-dimensional nanomaterials for peripheral nerve regeneration strategies by facilitating the formation of new vessels. Then, we analyze the mechanism that the newly-formed capillaries directionally and metabolically support neuronal regeneration. Finally, we prospect that the two-dimensional nanomaterials should be a potential solution to long range peripheral nerve defect. To further enhance the therapeutic effects of two-dimensional nanomaterial, strategies which help remedy the energy deficiency after peripheral nerve injury could be a viable solution.

show abstract

“…The integration of chemical and physical cues utilizing nanostructured scaffolds is fascinating. [ 22–28 ] However, there is only limited knowledge about regulating the IPS cells’ interfacial interactions and the effect on their neural differentiation.…”

Section: Introductionmentioning

confidence: 99%

Multivalent Polyanionic 2D Nanosheets Functionalized Nanofibrous Stem Cell‐based Neural Scaffolds

Xia

Yang

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

Because developed neural cells are no longer regenerative and proliferative, achieving neural regenerations by using induced pluripotent stem cells (IPS cells) for nerve diseases have recently attracted much attention. Since the IPS cells’ growth and differentiation can be manipulated by different physical and chemicals cues, scaffolds combining the beneficial nanostructures and extracellular matrix may become an ideal interface to promote IPS cells’ neural differentiation. In this work, a biocompatible and multivalent polyanion, hyperbranched polyglycerol sulfate, is used to modify the graphene oxide to obtain bio‐adhesive 2D nanosheets. After coating electrospinning nanofibers, the 2D nanosheets‐functionalized nanofibrous scaffolds are applied to mediate the proliferation, lineage specification, and neural differentiation of IPS cells. The results suggest that the modified scaffolds can improve the adhesion and proliferation of IPS cells combined with high efficiency in maintaining their stemness. During the neural differentiation process, the scaffolds can promote neural differentiation and their maturity, meanwhile decreasing the lineage specification toward astrocyte. Overall, this study not only provides new multivalent/bio‐adhesive nanofibrous scaffolds that integrate the chemical and physical cues to facilitate the targeted neural differentiation of IPS cells but also presents a novel pathway for the fabrication of carbon nanomaterials‐based biocomposites in regenerative therapies.

show abstract

Preparation and Characterization of Paclitaxel/Chitosan Nanosuspensions for Drug Delivery System and Cytotoxicity Evaluation In Vitro

Cited by 27 publications

References 38 publications

Chirality Transfer in Supramolecular Co-assembled Fibrous Material Enabling the Visual Recognition of Sucrose

Chirality Transfer in Supramolecular Co-assembled Fibrous Material Enabling the Visual Recognition of Sucrose

Two-Dimensional Nanomaterials for Peripheral Nerve Engineering: Recent Advances and Potential Mechanisms

Multivalent Polyanionic 2D Nanosheets Functionalized Nanofibrous Stem Cell‐based Neural Scaffolds

Contact Info

Product

Resources

About