Preparation and characterization of poly <b>ε</b>-caprolactone-gelatin/multi-walled carbon nanotubes electrospun scaffolds for cartilage tissue engineering applications

Zadehnajar, Parisa; Akbari, Babak; Karbasi, Saeed; Mirmusavi, Mohammad Hussein

doi:10.1080/00914037.2018.1563088

Cited by 62 publications

(35 citation statements)

References 34 publications

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“…It resulted in a more porous structure, however, with limited control over spatial arrangement [ 115 ]. There are several papers where CNTs are used in a composite material with PCL [ 116 , 117 ] and polyurethane [ 118 , 119 ].…”

Section: Methods Of Scaffold Fabricationmentioning

confidence: 99%

Utilization of Carbon Nanotubes in Manufacturing of 3D Cartilage and Bone Scaffolds

et al. 2020

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Cartilage and bone injuries are prevalent ailments, affecting the quality of life of injured patients. Current methods of treatment are often imperfect and pose the risk of complications in the long term. Therefore, tissue engineering is a rapidly developing branch of science, which aims at discovering effective ways of replacing or repairing damaged tissues with the use of scaffolds. However, both cartilage and bone owe their exceptional mechanical properties to their complex ultrastructure, which is very difficult to reproduce artificially. To address this issue, nanotechnology was employed. One of the most promising nanomaterials in this respect is carbon nanotubes, due to their exceptional physico-chemical properties, which are similar to collagens—the main component of the extracellular matrix of these tissues. This review covers the important aspects of 3D scaffold development and sums up the existing research tackling the challenges of scaffold design. Moreover, carbon nanotubes-reinforced bone and cartilage scaffolds manufactured using the 3D bioprinting technique will be discussed as a novel tool that could facilitate the achievement of more biomimetic structures.

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Section: Methods Of Scaffold Fabricationmentioning

confidence: 99%

Utilization of Carbon Nanotubes in Manufacturing of 3D Cartilage and Bone Scaffolds

et al. 2020

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“…Cell culture study showed that the nanocomposite scaffolds did not have any cytotoxicity. According to their results, the PCL-gelatin/MWNTs nanocomposite scaffold can be appropriate for cartilage tissue engineering applications [ 89 ]. Sharifi et al used Chondroitin sulfate and gelatin (GEL-CS) as a component of cartilage extracellular matrix to incorporated by polycaprolactone (PCL)nanofibers utilizing co-electrospinning process.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Biomedical Applications of Nanofibers

Habibi

Talebian

2021

Russ J Appl Chem

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The idea of creating replacement for damaged or diseased tissue, which will mimic the physiological conditions and simultaneously promote regeneration by patients’ own cells, has been a major challenge in the biomedicine for more than a decade. Therefore, nanofibers are a promising solution to address these challenges. Nanofiber technology is an exciting area attracting the attention of many researchers as a potential solution to these current challenges in the biomedical field such as burn and wound care, organ repair, and treatment for osteoporosis and various diseases. Nanofibers mimic the porous topography of natural extracellular matrix (ECM), hence they are advantageous for tissue regeneration . In biomedical engineering, electrospinning exhibits advantages as a tissue engineering scaffolds producer, which can make appropriate resemblance in physical structure with ECM. This is because of the nanometer scale of ECM fibrils in diameter, which can be mimicked by electrospinning procedure as well as its porous structure. In this review, the applications of nanofibers in various biomedical areas such as tissue engineering, wound dressing and facemask, are summarized. It provides opportunities to develop new materials and techniques that improve the ability for developing quick, sensitive and reliable analytical techniques.

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“…Bone tissue engineering [163] α-TCP/collagen MC3T3-E1 cells The scaffold showed good mechanical properties and cellular activities Bone tissue engineering [164] collagen type I/agarose with sodium alginate Primary chondrocytes Addition of collagen or agarose had an impact on gelling behavior and improving mechanical strength. The collagen facilitated cell adhesion, accelerated cell proliferation, and enhanced the expression of cartilage-specific genes, (Acan, Sox9, and Col2a1) Bone tissue engineering [165] Fibrin and wollastonite Loaded with rabbit BMSCs Cartilage tissue [175] Phase separation process Cartilage ECM-derived/PLGA-β-TCP-collagen type I…”

Section: D Bioprintingmentioning

confidence: 99%

Tissue Engineering in Musculoskeletal Tissue: A Review of the Literature

et al. 2021

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Tissue engineering refers to the attempt to create functional human tissue from cells in a laboratory. This is a field that uses living cells, biocompatible materials, suitable biochemical and physical factors, and their combinations to create tissue-like structures. To date, no tissue engineered skeletal muscle implants have been developed for clinical use, but they may represent a valid alternative for the treatment of volumetric muscle loss in the near future. Herein, we reviewed the literature and showed different techniques to produce synthetic tissues with the same architectural, structural and functional properties as native tissues.

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Preparation and characterization of poly ε-caprolactone-gelatin/multi-walled carbon nanotubes electrospun scaffolds for cartilage tissue engineering applications

Cited by 62 publications

References 34 publications

Utilization of Carbon Nanotubes in Manufacturing of 3D Cartilage and Bone Scaffolds

Utilization of Carbon Nanotubes in Manufacturing of 3D Cartilage and Bone Scaffolds

Biomedical Applications of Nanofibers

Tissue Engineering in Musculoskeletal Tissue: A Review of the Literature

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