Preparation and characterization of self-assembled nanoparticles of 6-O-cholesterol-modified chitosan for drug delivery

Chen, Mingmao; Liu, Yan; Yang, Wenzhi; Li, Xuemin; Liu, Lingrong; Zhou, Zhimin; Wang, Yinsong; Li, Ruifeng; Zhang, Qiqing

doi:10.1016/j.carbpol.2011.01.012

Cited by 51 publications

(31 citation statements)

References 48 publications

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“…From Fig.5, the decrease of DOX release rate was observed when the drug loading contents increased. The results were consistent with the previously reported phenomena [15,21]. At a higher drug loading content, the hydrophobic drug partially crystallized inside nanoparticles, and phase separation occurred, reducing the drug release rate [29].…”

Section: Page 12 Of 30supporting

confidence: 93%

“…Cholesterol succinate (CHS) was synthesized following the procedure reported previously [21]. DOX hydrochloride (DOX·HCl), glycol chitosan (M W = 2.5 × 10 5 …”

Section: Methodsmentioning

confidence: 99%

“…The mean diameter of Bio-CHGC nanoparticles was 305.2 nm, and the polydispersity index was 0.103. The zeta potential of Bio-CHGC A c c e p t e d M a n u s c r i p t 10 nanoparticles was +15.02 mv, which suggested that this nanoparticle system would be stable in aqueous phase [21].…”

Section: Characterization Of Bio-chgc Nanoparticles and Drug Loadingmentioning

confidence: 99%

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Collagen/chitosan film containing biotinylated glycol chitosan nanoparticles for localized drug delivery

Chen

Huang

Cao

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Section: Page 12 Of 30supporting

confidence: 93%

“…Cholesterol succinate (CHS) was synthesized following the procedure reported previously [21]. DOX hydrochloride (DOX·HCl), glycol chitosan (M W = 2.5 × 10 5 …”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Collagen/chitosan film containing biotinylated glycol chitosan nanoparticles for localized drug delivery

Chen

Huang

Cao

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…Ca 2+ was introduced to gel the ALG moieties at the outer shell of NP that encapsulated hydroxycamptothecin (HCPT) [104]. Chitosan has been chemically modified by linking hydrophobic groups on hydroxyl [105] or amino groups. Due to the higher reactivity of amino groups, the majority of the modifications have used this group mainly through N--acylation reactions [106] [107].…”

Section: Figurementioning

confidence: 99%

Self-assembling polymer systems for advanced treatment of cancer and inflammation

Palao-Suay

Gómez‐Mascaraque

Aguilar

et al. 2016

Progress in Polymer Science

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“…7 In order to improve the drug solubility and enhance the antitumor activity of SN38, various preparations have been developed in recent years, such as liposome-based formulations, 8,9 polymeric micelles, and complex compounds. [10][11][12][13][14][15] Unfortunately, these preparations are accompanied by inherent shortcomings, especially the need for complex preparation methods, low drug loading, and inefficient delivery. To overcome these problems, macromolecular prodrug systems that self-assemble in aqueous medium have been investigated in recent years.…”

Section: Introductionmentioning

confidence: 99%

Comparison of two self-assembled macromolecular prodrug micelles with different conjugate positions of SN38 for enhancing antitumor activity

Liu¹,

Piao²,

Gao³

et al. 2015

IJN

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7-Ethyl-10-hydroxycamptothecin (SN38), an active metabolite of irinotecan (CPT-11), is a remarkably potent antitumor agent. The clinical application of SN38 has been extremely restricted by its insolubility in water. In this study, we successfully synthesized two macromolecular prodrugs of SN38 with different conjugate positions (chitosan-(C 10 -OH)SN38 and chitosan-(C 20 -OH)SN38) to improve the water solubility and antitumor activity of SN38. These prodrugs can self-assemble into micelles in aqueous medium. The particle size, morphology, zeta potential, and in vitro drug release of SN38 and its derivatives, as well as their cytotoxicity, pharmacokinetics, and in vivo antitumor activity in a xenograft BALB/c mouse model were studied. In vitro, chitosan-(C 10 -OH)SN38 (CS-(10s)SN38) and chitosan-(C 20 -OH) SN38 (CS-(20s)SN38) were 13.3- and 25.9-fold more potent than CPT-11 in the murine colon adenocarcinoma cell line CT26, respectively. The area under the curve (AUC) 0–24 of SN38 after intravenously administering CS-(10s)SN38 and CS-(20s)SN38 to Sprague Dawley rats was greatly improved when compared with CPT-11 (both P <0.01). A larger AUC 0–24 of CS-(20s)SN38 was observed when compared to CS-(10s)SN38 ( P <0.05). Both of the novel self-assembled chitosan-SN38 prodrugs demonstrated superior anticancer activity to CPT-11 in the CT26 xenograft BALB/c mouse model. We have also investigated the differences between these macromolecular prodrug micelles with regards to enhancing the antitumor activity of SN38. CS-(20s)SN38 exhibited better in vivo antitumor activity than CS-(10s)SN38 at a dose of 2.5 mg/kg ( P <0.05). In conclusion, both macromolecular prodrug micelles improved the in vivo conversion rate and antitumor activity of SN38, but the prodrug in which C 20 -OH was conjugated to macromolecular materials could be a more promising platform for SN38 delivery.

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Preparation and characterization of self-assembled nanoparticles of 6-O-cholesterol-modified chitosan for drug delivery

Cited by 51 publications

References 48 publications

Collagen/chitosan film containing biotinylated glycol chitosan nanoparticles for localized drug delivery

Collagen/chitosan film containing biotinylated glycol chitosan nanoparticles for localized drug delivery

Self-assembling polymer systems for advanced treatment of cancer and inflammation

Comparison of two self-assembled macromolecular prodrug micelles with different conjugate positions of SN38 for enhancing antitumor activity

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