Preparation and characterization of the electrospun nanofibers loaded with clarithromycin

Abstract

Electrospinning was applied to prepare the drug-loaded nanofibers for potential use in drug delivery and wound healing. Clarithromycin (CLM) was selected as the model drug, whereas poly(L-lactic acid) (PLLA) was used as the biodegradable and biocompatible polymer carrier. The low toxicity solvents were tested, and the morphology and structures of the nanofibers were investigated by scanning electron microscopy (SEM), Fourier transform infrared spectrometer (FTIR), and X-ray diffraction (XRD). PLLA and its composite of CLM were electrospun using the solvents of dichloromethane and acetone. SEM images showed that the diameters of the electrospun PLLA fibers were about 1000 nm, decreased to about 400 nm when 5 wt % CLM was loaded. With the increase of the amount the drug loaded, the diameters of the fibers gradually decreased and their distributions varied. The drug aggregates of any kind were not observed on the surfaces of the fibers. FTIR spectra revealed that CLM was incorporated into the macromolecular carrier of PLLA by formation of the hydrogen bonds but no new functional groups in the structure of the composite nanofibers were formed. XRD patterns indicated that the drug distributed in the composite nanofibers existed in the noncrystalline form.

Electrospun poly(L-lactide) membranes containing a single drug or multiple drug system for antimicrobial wound dressings

“…This indicates that the incorporation of the drug does not favor the polymer crystallization. The obtained results are in accordance with the data for other polymer/ drug systems 11,[22][23][24] and indicate that electrospinning is an effective method for one-step incorporation of drugs in fibrous membranes where they are to be found in the amorphous state.…”

Crystallization of calcium sulfate on polymeric surfaces

“…The majority of commercial RO/NF membranes are thin-film polyamide membranes and thus studies of mineral scaling have been limited to polyamide surfaces [14,15], with a few studies also considering cellulose acetate surfaces [16,17]. It has been shown that the membrane surface topography [18] and chemistry [19][20][21] can affect mineral salt scaling process significantly.…”

Solid-State NMR Characterization of High-Loading Solid Solutions of API and Excipients Formed by Electrospinning

“…A recently reported method of coprocessing API and polymer directly from a solution is to utilize the technique of electrospinning. [1][2][3][4][5][6][7][8][9][10][11] Electrospinning has been used for various applications since 1903, when Morton first patented the process. 12 In electrospinning, a charged solution containing a polymer, solvent, and other desired compounds is pumped through a needle, producing a drop at the tip.…”

“…Many studies have shown that electrospinning a solution containing API, polymer, and solvent results in 200-nm-to 2-:m-sized fibers that contain drug dispersed within the polymer. [1][2][3][4][5][6][7][8][9][10][11] Because of the rapid evaporation rate, the drug is often present in the fibers in the amorphous form. [4][5][6]8,9 This is an exciting result for researchers studying poorly water-soluble drugs, as high surface area and amorphous API both aid in increasing solubility.…”