Preparation and drug release properties of norisoboldine-loaded chitosan microspheres

He, Miao; Wang, Haiyan; Dou, Wei; Chou, Gui‐Xin; Wei, Xiaohui; Wang, Zhengtao

doi:10.1016/j.ijbiomac.2016.06.076

Cited by 19 publications

(8 citation statements)

References 37 publications

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“…To tackle these obstacles, many approaches have been developed for TP‐enriched food products such as 3D printing technology, microencapsulation, and the water‐in‐oil emulsion method (Acevedo et al., 2020; Massounga Bora et al., 2018; Ye et al., 2020). Encapsulation has been reported to improve the stability of bioactive substances (Feng et al., 2018; He et al., 2016; Shen & Quek, 2014). Feng et al.…”

Section: Introductionmentioning

confidence: 99%

Preparation and antioxidant activity evaluation of tea polyphenol–collagen–alginate microspheres

Ruan

Pei

et al. 2021

J. Food Process. Preserv.

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Tea polyphenol (TP)‐loaded alginate–collagen microspheres were prepared by ionic gelation method by Ca2+ as a cation and alginate as an anion. The morphology of the prepared microspheres was characterized by scanning electron microscopy. TP appeared in an amorphous state with an average size of 510.26 μm when encapsulated in the microspheres. The loading capacity (LC%) and encapsulation efficiency (EE%) were about 5.11% (w/w) and 33.51%, respectively. These microencapsulated beads were evaluated as a pH‐sensitive system for the delivery of tea polyphenol. At pH 7.4, the amounts of TP released increased significantly as compared with those released at pH 1.2. The 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical‐scavenging activity and the stability of the microencapsulated TP were higher than that of free TP. Overall, the TP microspheres could improve antioxidant activity and the storage stability of TP at room temperature for 6 months. Practical applications TP is widely used in the food industry, medicine, and daily health care because of its antioxidant and antibacterial effects. However, TP is sensitive to temperature, light, pH, oxygen, etc., which risks its stability during processing, storage, and transportation. The encapsulation using microspheres is of great significance for improving the antioxidant activity of TP. In conclusion, microspheroidization is an attractive approach to preserving TP efficiency during food processing and enables a targeted delivery upon consumption.

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Section: Introductionmentioning

confidence: 99%

Preparation and antioxidant activity evaluation of tea polyphenol–collagen–alginate microspheres

Ruan

Pei

et al. 2021

J. Food Process. Preserv.

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“…Encapsulation is a procedure that has been applied to bioactive compounds. It aims to reduce or prevent degradation processes until the compound of interest reaches the sites where absorption is desired . Also, this technique has been shown to increase lutein bioavailability .…”

Section: Introductionmentioning

confidence: 99%

“…It aims to reduce or prevent degradation processes until the compound of interest reaches the sites where absorption is desired. 12,17 Also, this technique has been shown to increase lutein bioavailability. 18,19 It is necessary to encapsulate lutein using biocompatible and hydrophilic materials in order to protect it from damage and improve its stability.…”

Section: Introductionmentioning

confidence: 99%

Development and evaluation of lutein‐loaded alginate microspheres with improved stability and antioxidant

Huang

Bai

et al. 2019

J Sci Food Agric

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Background Lutein has been of great interest to the food processing and pharmaconutrient industries owing to its beneficial effects on human health. However, lutein is very sensitive to heat, light, pH and oxidative conditions, which limits its application in food systems. The present study aimed to prepare lutein–alginate microspheres by a calcium chloride gelation method with the purpose of improving the stability and antioxidant abilities of lutein. Results The loading capacity of lutein in the microspheres was approximately 5.3% (w/w) and the entrapment efficiency was about 63%. The loaded microspheres were nearly spherical with an average size of 150 μm. They exhibited a crimped surface by scanning electron microscopy. The lutein was in amorphous state by X‐ray powder diffraction. Analysis by Fourier transform infrared spectroscopy and molecular docking revealed an intermolecular hydrogen bond interaction between lutein and sodium alginate. In vitro release experiments showed that the microspheres presented slower release at acidic conditions than at neutral intestinal conditions. The 2,2‐diphenyl‐1‐picrylhydrazyl radical scavenging activity of the microencapsulated lutein was higher than that of free lutein. The stability of lutein in the microspheres was improved significantly when compared with that of free lutein at various temperatures. Conclusion The present work successfully developed well‐protected lutein–alginate microspheres. This indicates that it is feasible to use microspheres loaded with lutein as antioxidant functional ingredients in food products. © 2019 Society of Chemical Industry

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“…Chitosan is the unique alkaline polysaccharide in nature, which has many physiological functions such as antibacterial, anticancer, and lipid lowering [24,25].…”

Section: Introductionmentioning

confidence: 99%

Preparation and drug loading behavior of pH-responsive Fe3O4/CMCS/ALS magnetic nanoparticles

Liu

Chen

Tan

et al. 2022

Preprint

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In order to improve the utilization of anti-tumor drugs, a magnetic delivery system for targeted drug was reported. Firstly, aminated modified sodium lignosulfonate (ALS) and carboxymethyl chitosan (CMCS) were used to fabricate nano Fe3O4 to obtain pH-responsive Fe3O4/CMCS/ALS magnetic nanoparticles. Then the magnetic nanoparticles were loaded with doxorubicin hydrochloride (DOX), realizing the targeted delivery and controlled release of anti-tumor drugs. It was found that the amount of crosslinking agent and emulsifier were the key factors affecting the morphology and size of the magnetic nanoparticles. Under optimized conditions, the particle size was about 79.9 ~ 169.9 nm, exhibiting excellent drug loading capacity, good magnetic and pH responsiveness, with an isoelectric point of 4. When the drug-to-material ratio was 11:10, the DOX loading rate and the encapsulation rate of the nanoparticles was 48.68% and 86.23%. While the Fe3O4/CMCS/ALS-DOX could release 63.14%, 56.71%, and 14.28% of DOX at pH 4, 5.3, and 7.4, respectively. The results showed that the Fe3O4/CMCS/ALS particles exhibited excellent drug loading and release behavior based on the pH responsiveness, which could be described by Langmuir adsorption model and Fick's law of diffusion respectively. MTT assay and Live/dead staining experiments also showed that the drug-loaded particles had obvious growth inhibition on cancer cells. So it could be used as a potential drug carrier.

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Preparation and drug release properties of norisoboldine-loaded chitosan microspheres

Cited by 19 publications

References 37 publications

Preparation and antioxidant activity evaluation of tea polyphenol–collagen–alginate microspheres

Preparation and antioxidant activity evaluation of tea polyphenol–collagen–alginate microspheres

Development and evaluation of lutein‐loaded alginate microspheres with improved stability and antioxidant

Preparation and drug loading behavior of pH-responsive Fe3O4/CMCS/ALS magnetic nanoparticles

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