Preparation and drug release properties of chitosan/organomodified palygorskite microspheres

Wu, Jie; Ding, Shangwu; Chen, Jing; Zhou, Su-Qin; Ding, Hongyan

doi:10.1016/j.ijbiomac.2014.04.030

Cited by 44 publications

(18 citation statements)

References 27 publications

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“…Higher clay content in the beads might have reduced the void space available to hold water in the structure [16]. The average external porosity of all the beads was around 55% (Table 1).…”

Section: Physical Properties Of Chitosan-palygorskite Compositesmentioning

confidence: 99%

Structural evolution of chitosan–palygorskite composites and removal of aqueous lead by composite beads

Rusmin

Sarkar

Liu

et al. 2015

Applied Surface Science

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a b s t r a c tThis paper investigates the structural evolution of chitosan-palygorskite (CP) composites in relation to variable mass ratios of their individual components. The composite beads' performance in lead (Pb) adsorption from aqueous solution was also examined. The composite beads were prepared through direct dispersion of chitosan and palygorskite at 1:1, 1:2 and 2:1 mass ratios (CP1, CP2 and C2P, respectively). Analyses by Fourier transform Infrared (FTIR) spectroscopy, Brunauer-Emmett-Teller (BET) surface area, X-ray diffraction (XRD) and scanning electron microscopy (SEM) confirmed the dependence of the composites' structural characteristics on their composition mass ratio. The chitosan-palygorskite composite beads exhibited a better Pb adsorption performance than the pristine materials (201.5, 154.5, 147.1, 27.7 and 9.3 mg g −1 for CP1, C2P, CP2, chitosan and palygorskite, respectively). Adsorption of Pb by CP1 and CP2 followed Freundlich isothermal model, while C2P fitted to Langmuir model. Kinetic studies showed that adsorption by all the composites fitted to the pseudo-second order model with pore diffusion also acting as a major rate governing step. The surface properties and specific interaction between chitosan and palygorskite in the composites were the most critical factors that influenced their capabilities in removing toxic metals from water.

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“…Higher clay content in the beads might have reduced the void space available to hold water in the structure [16]. The average external porosity of all the beads was around 55% (Table 1).…”

Section: Physical Properties Of Chitosan-palygorskite Compositesmentioning

confidence: 99%

Structural evolution of chitosan–palygorskite composites and removal of aqueous lead by composite beads

Rusmin

Sarkar

Liu

et al. 2015

Applied Surface Science

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“…In the last two decades, researchers have shown much interest in the use of nanoclay materials, most notably Kaolinite [1,2], montmorillonite [3][4][5], diatomic [6][7][8], palygorskite [9], and halloysite [10][11][12], especially in biomedical field. This interest is largely stems from the human interest due to its biocompatibility, biostability, degradability, non-toxic and increase the drug efficiency in drug delivery systems [13].…”

Section: Introductionmentioning

confidence: 99%

Sodium Alginate/Gelatin Microbeads-Intercalated With Kaolin Nanoclay for Emerging Drug Delivery in Wilson’s Disease

et al. 2019

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Objective: The aim of the present study was to fabricate and evaluate the drug release studies using Sodium Alginate (SA) and Gelatin (GE) microbeads intercalated with Kaolin (KA) nanoclay for sustained release of D-Penicillamine (D-PA). Methods: Sodium alginate/gelatin/Kaolin blend microbeads were prepared by an extrusion method by using glutaraldehyde (GA) as a crosslinker. The obtained microbeads were characterized by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and X–ray diffraction (XRD). Drug release kinetics of the microbeads was investigated in simulated intestinal fluid (pH 7.4) at 37 °C. Results: Microbeads formation was confirmed by FTIR spectroscopy. X-RD reveals that the KA should be intercalated with the drug and also it confirms the molecular level dispersion of D-Penicillamine into microbeads. Scanning Electron Microscopy (SEM) studies reveal that the beads were in spherical shape with some wrinkled depressions on the surface. The in vitro release study indicates the D-Penicillamine released in a controlled manner. The in vitro release kinetics was assessed by Korsmeyer-Peppas equation and the ‘n’ value lies in between 0.557-0.693 indicates Non-Fickian diffusion process. Conclusion: The results suggest that the developed KA intercalated microbeads are good potential drug carrier for the controlled release of D-PA.

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“…Nanocompósitos com polietilenoamina Ácido fólico [11] Nanocompósito com polypyrrole Aspirina [12] Microesferas de quitosana utilizando PLG organofilizada Diclofenaco sódico [13] PLG sozinha Lapachol [14] PLG liofilizada Ofloxacina [15] Compósito para a formação de hidrogel com carboximetilcelulose-g-poli(ácido acrílico) e alginato de sódio Diclofenaco [16] Compósito para a formação de hidrogel goma guar-gpoli(ácido acrílico) e alginato de sódio Diclofenaco [17] Sepiolita Pilarização Óxido nítrico [18] Fonte: Arquivo do autor, 2015.…”

Section: Forma Utilizada Fármaco Referênciaunclassified

“…Dentre os artigos que utilizavam somente as argilas para a liberação modificada, as mesmas foram submetidas a algum processo físico ou químico, como a liofilização ou organofilização, respectivamente, a fim de aumentar a área superficial e o volume dos poros, o que acarretou no melhoramento das propriedades desejadas quanto à sua utilização como veículo na vetorização de fármacos [13,16].…”

Section: Forma Utilizada Fármaco Referênciaunclassified

Utilização de argilas fibrosas e tubulares para a liberação modificadas de fármacos: uma revisão

Silva¹,

Vilarinho²,

Barud

et al. 2016

Matéria (Rio J.)

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RESUMONas últimas décadas o uso de argilominerais nas áreas de Ciência e Engenharia de Materiais tem recebido notória atenção para a sua utilização no carreamento de fármacos. Dentre os diversos tipos de argilas, as fibrosas e as tubulares tem sido utilizadas na preparação de bionanocompósitos, devido as suas propriedades inerentes, como exemplo a elevada área superficial. Esta pesquisa visou o levantamento bibliográfico da utilização das argilas tubulares e fibrosas para o carreamento de fármacos. A busca por artigos foi realizado no banco de dados Web of Science, utilizando combinação dos termos: Fibrous Clay and drug delivery, Tubular Clay and drug delivery, Halloysite and drug delivery, Imogolite and drug delivery, Palygoskite and drug delivery e Sepiolite and drug delivery. Foram encontrados o total de 36 artigos durante a pesquisa. Observouse que a maioria dos artigos utilizam as argilas em combinação com outros materiais (com formação de compósitos e blendas), principalmente polímeros, a fim de expandir as propriedades que melhoram a vetorização de insumos farmacêuticos ativos (IFAs), tais como a modificação do tamanho dos poros, do pH, da energia de ligação entre as moléculas, entre outros. Assim, evidencia-se que o interesse pela utilização das argilas no campo terapêutico tem aumentado, mostrando a relevância de pesquisas na área de medicamentos e materiais.Palavras-chave: argila fibrosa, argila tubular, argilominerais, carreamento de fármacos. ABSTRACTIn recent decades the use of clay minerals in the areas of Materials Science and Engineering has received notable attention for its use in carrying of drugs. Among the various types of clay, and fibrous tubes have been used in the preparation of bionanocompósitos due to their inherent properties, for example high surface area. This research aimed a review at the literature of the use of tubular and fibrous clays for the carrying of drugs. The search for articles was conducted in the Web of Science database, using combination of terms: Fibrous Clay and drug delivery, Tubular Clay and drug delivery, Halloysite and drug delivery, imogolite and drug delivery, drug delivery and Palygoskite and Sepiolite and drug delivery. Found total of 36 articles during the search. It was observed that most of the clay articles used in combination with other materials (with formation of composites and blends), in particular polymers in order to extend the properties that improve the vectoring of active pharmaceutical ingredients (APIs), such as modification pore size, the pH, the binding energy between molecules, among others. Thus, it is clear that the interest in the use of clays in the therapeutic field has increased, showing the relevance of research in the area of drugs and materials.

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Preparation and drug release properties of chitosan/organomodified palygorskite microspheres

Cited by 44 publications

References 27 publications

Structural evolution of chitosan–palygorskite composites and removal of aqueous lead by composite beads

Structural evolution of chitosan–palygorskite composites and removal of aqueous lead by composite beads

Sodium Alginate/Gelatin Microbeads-Intercalated With Kaolin Nanoclay for Emerging Drug Delivery in Wilson’s Disease

Utilização de argilas fibrosas e tubulares para a liberação modificadas de fármacos: uma revisão

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