Preparation and evaluation of a BisGMA-free dental composite resin based on a novel trimethacrylate monomer

Pérez‐Mondragón, Alma Antonia; Cuevas‐Suárez, Carlos Enrique; González-López, José Abraham; Trejo‐Carbajal, Nayely; Meléndez-Rodrı́guez, Myriam; Herrera‐González, Ana M.

doi:10.1016/j.dental.2020.02.005

Cited by 37 publications

(21 citation statements)

References 28 publications

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“…Neat commercial resin consisting of 50 wt % Bis-GMA and 50 wt % TEGDMA (5B5T) served as the control. , CQ (0.2 wt %) and 4-EDMAB (0.8 wt %) were used as the photoinitiators with respect to the total concentration of monomers. The detailed compositions of all dental resins are listed in Table , where the experimental resins are coded as x M t Bet y B z T with x , y , and z representing the weight fractions of the betulin-based comonomers (M t Bet, t = 1 or 2), Bis-GMA (B), and TEGDMA (T), respectively.…”

Section: Experimental Sectionmentioning

confidence: 99%

Synthesis and Characterization of Methacrylate-Functionalized Betulin Derivatives as Antibacterial Comonomer for Dental Restorative Resins

Zhang

Wang

et al. 2021

ACS Biomater. Sci. Eng.

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Secondary caries is the primary cause of composite restoration failures, resulting from marginal leakage and bacterial accumulation in the oral environment. Antibacterial dental composites, especially antibacterial monomers, have emerged as a promising strategy to inhibit secondary caries, which is pivotal to prolonging the lifespan of dental restorations. In this work, monomethacrylate- and dimethacrylate-functionalized betulin derivatives (M1Bet and M2Bet) were synthesized via an esterification reaction and served as antibacterial comonomers to develop novel dental resin formulations, in which M1Bet and M2Bet were incorporated to partially or completely replace bisphenol A glycerolate dimethacrylate (Bis-GMA). The control resin was a mixture based on Bis-GMA and tri(ethyleneglycol) dimethacrylate (TEGDMA) with a weight ratio of 50:50 (5B5T). The effect of the resin compositions and the chemical structures of M1Bet and M2Bet on the rheology behavior, optical property, polymerization kinetics, mechanical performance, cell viability, and antibacterial activity of dental resins were systematically investigated. Among all materials, the 1M2Bet4B5T resin with 10 wt % substitution of Bis-GMA by M2Bet exhibited comparable viscosity, higher light transmittance, improved degree of conversion, and mechanical properties compared with 5B5T. After incubation for 24 h, this optimal resin also possessed the best antibacterial activity against Streptococcus mutans, which had a significantly lower bacterial concentration (1.53 × 109 CFU/mL) than 5B5T (9.03 × 109 CFU/mL). Introducing betulin-based comonomers into dental resins is a potential strategy to develop antibacterial dental materials without sacrificing physical–mechanical properties.

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Section: Experimental Sectionmentioning

confidence: 99%

Synthesis and Characterization of Methacrylate-Functionalized Betulin Derivatives as Antibacterial Comonomer for Dental Restorative Resins

Zhang

Wang

et al. 2021

ACS Biomater. Sci. Eng.

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“…Porous nature of Hydroxyapatite results into additional suitable situation for cell adhesion and Proliferation which results in to good biocompatibility character [22]. further, some initial biocompatibility tests are essential that allow various treatments to be evaluated without the necessity for ample and whole belief on in vitro animal testing and clinical trials [23].…”

Section: Resultsmentioning

confidence: 99%

Bio Ceramics: New Material from Mangrove Bark

Powar¹

2020

Adv. Mater. Lett.

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“…According to the results, all materials underwent an expansion after water storage, which suggests highly hydrophilicity of the materials evaluated 34 . The organic matrix used for the formulation of the endodontic sealers included methacrylate monomers that contain a large amount of hydrophilic groups in their structure, which ones can form hydrogen bonds with water molecules, with the consequent expansion of the material 35 . Furthermore, the leakage of unreacted components, like the vegetable extracts, from the polymeric matrix could have contributed to promoting the expansion of the materials.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial and physical properties of experimental endodontic sealers containing vegetable extracts

Santos

Barboza

Schneider

et al. 2021

Sci Rep

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To assess the antimicrobial activity and the physical properties of resin-based experimental endodontic sealers with the incorporation of vegetable extracts obtained from Bixa orellana, Mentha piperita, and Tagetes minuta species. The extracts were obtained and characterized by gas chromatography-mass spectrometry (GC–MS), and minimum inhibitory concentration (MIC) against Streptococcus mutans, Enterococcus faecalis, and Candida albicans. The extracts were individually incorporated into a dual-cure experimental sealer at a mass concentration of 0.5%. A commercial reference RealSeal was used. The sealers were evaluated by measuring the setting time, degree of conversion, dimensional stability, radiopacity, flow, and film thickness of these materials, also and its antimicrobial effect was evaluated using the direct contact test. Data were statistically analyzed by analysis of variance and Tukey’s post-hoc test at α = 0.05 significance level. The physical properties were not influenced by the addition of the vegetable extracts (p > 0.05). For S. mutans, only T. minuta and B. orellana groups presented antibacterial activity after 24 h of contact (p < 0.05). All extracts evidenced an antibacterial effect against E. faecalis (p < 0.05). The experimental sealers hold promise as a novel vegetable sealer with great antimicrobial activity and also great physical–mechanical properties. Nonetheless, more studies are needed.

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Preparation and evaluation of a BisGMA-free dental composite resin based on a novel trimethacrylate monomer

Cited by 37 publications

References 28 publications

Synthesis and Characterization of Methacrylate-Functionalized Betulin Derivatives as Antibacterial Comonomer for Dental Restorative Resins

Synthesis and Characterization of Methacrylate-Functionalized Betulin Derivatives as Antibacterial Comonomer for Dental Restorative Resins

Bio Ceramics: New Material from Mangrove Bark

Antimicrobial and physical properties of experimental endodontic sealers containing vegetable extracts

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