Preparation and evaluation of ibuprofen-loaded microemulsion for improvement of oral bioavailability

Hu, Liandong; Yang, Juan; Liu, Wei; Li, Li

doi:10.3109/10717544.2010.522613

Cited by 50 publications

(24 citation statements)

References 23 publications

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“…Microemulsion improves drug solubilization, absorption and permeability (Jain et al, 2009;Mostafa et al, 2014). It also provides protection against enzymatic hydrolysis (Hu et al, 2011). The selection of suitable surfactant combinations is a critical parameter in order to make thermodynamically stable emulsion (Wang et al, 2009).…”

Section: Microemulsionmentioning

confidence: 99%

Advances in nanotechnology-based carrier systems for targeted delivery of bioactive drug molecules with special emphasis on immunotherapy in drug resistant tuberculosis – a critical review

et al. 2015

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From the early sixteenth and seventeenth centuries to the present day of life, tuberculosis (TB) still is a global health threat with some new emergence of resistance. This type of emergence poses a vital challenge to control TB cases across the world. Mortality and morbidity rates are high due to this new face of TB. The newer nanotechnology-based drug-delivery approaches involving micro-metric and nano-metric carriers are much needed at this stage. These delivery systems would provide more advantages over conventional systems of treatment by producing enhanced therapeutic efficacy, uniform distribution of drug molecule to the target site, sustained and controlled release of drug molecules and lesser side effects. The main aim to develop these novel drug-delivery systems is to improve the patient compliance and reduce therapy time. This article reviews and elaborates the new concepts and drug-delivery approaches for the treatment of TB involving solid-lipid particulate drug-delivery systems (solid-lipid micro- and nanoparticles, nanostructured lipid carriers), vesicular drug-delivery systems (liposomes, niosomes and liposphere), emulsion-based drug-delivery systems (micro and nanoemulsion) and some other novel drug-delivery systems for the effective treatment of tuberculosis and role of immunomodulators as an adjuvant therapy for management of MDR-TB and XDR-TB.

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Section: Microemulsionmentioning

confidence: 99%

Advances in nanotechnology-based carrier systems for targeted delivery of bioactive drug molecules with special emphasis on immunotherapy in drug resistant tuberculosis – a critical review

et al. 2015

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“…The rat cyp2c6 and 2c11 are well-documented counterparts of human CYP2C9 (Vecera et al, 2011) and hence thought to be involved in the transformation of IBU. However, IBU is metabolized to a greater extent in humans as deduced from dose-normalized in vivo pharmacokinetic data (Hu et al, 2011;Kapil et al, 2004). …”

Section: Ibuprofen (Ibu)mentioning

confidence: 99%

Drug biokinetic and toxicity assessments in rat and human primary hepatocytes and HepaRG cells within the EU-funded Predict-IV project

Mueller

Hewitt

Richert

2015

Toxicology in Vitro

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“…Many research reports used distilled water [28][29][30] as media to determine the solubility of drug substance. Ibuprofen drug release from microemulsion was studied also in distilled water by Hu et al 31 Ibuprofen release profiles were similar for three kinds of microspheres in distilled water and with solution of low pH of 1.2 because of poor solubility of the drug. 32 Like ibuprofen many other non-steroidal anti-inflammatory drugs tend to self-associate by forming mixed-charged micelles or micelle-like structures and the solubility-pH profiles cannot be described properly with the Henderson-Hasselbalch eq.…”

Section: In-vitro Drug Releasementioning

confidence: 99%

Interactions between Ibuprofen and Silicified-MCC: Characterization, Drug Release and Modeling Approaches

Sahoo¹,

Nanda²,

Pramanik³

et al. 2019

ACSi

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Analysis of the binding interactions of ibuprofen and silicified-microcrystalline cellulose (SMCC) has been undertaken. Co-processing of ibuprofen with SMCC was carried out by solid state ball milling, and aqueous state equilibration followed by freeze drying to investigate the effect of silicified-microcrystalline cellulose on ligand. Molecular docking study revealed that ibuprofen formed complex through hydrogen bond with microcrystalline cellulose (MCC) and silicon dioxide (SiO 2); the binding energy between MCC and SiO 2 , and ibuprofen and SMCC were found as-1.11 and-1.73 kcal/mol respectively. The hydrogen bond lengths were varying from 2.028 to 2.056 Å. Interaction of Si atom of SMCC molecule with Pi-Orbital of ibuprofen has shown the bond length of 4.263 Å. Significant improvement in dissolution of ibuprofen has been observed as a result of interaction. Binary and ternary interactions revealed more stabilizing interactions with ibuprofen and SMCC compared to SMCC formation.

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Preparation and evaluation of ibuprofen-loaded microemulsion for improvement of oral bioavailability

Abstract: (2011) Preparation and evaluation of ibuprofen-loaded microemulsion for improvement of oral bioavailability, Drug Delivery, 18:1, 90-95,

Cited by 50 publications

References 23 publications

Advances in nanotechnology-based carrier systems for targeted delivery of bioactive drug molecules with special emphasis on immunotherapy in drug resistant tuberculosis – a critical review

Advances in nanotechnology-based carrier systems for targeted delivery of bioactive drug molecules with special emphasis on immunotherapy in drug resistant tuberculosis – a critical review

Drug biokinetic and toxicity assessments in rat and human primary hepatocytes and HepaRG cells within the EU-funded Predict-IV project

Interactions between Ibuprofen and Silicified-MCC: Characterization, Drug Release and Modeling Approaches

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