2005
DOI: 10.1097/01.mjt.0000162014.43743.e0
|View full text |Cite
|
Sign up to set email alerts
|

Preparation and Evaluation of Verapamil Hydrochloride Microcapsules

Abstract: Verapamil was encapsulated with ethylcellulose (EC) and cellulose acetate (CA) in various ratios of drug and polymer by the hot melt technique and the prepared microcapsules were evaluated for size range, drug content, drug release profiles, and kinetics of drug release. The microcapsules were compressed into tablets to study the variation of drug release between the 2 types of formulations (ie, microcapsules and tablets). The size analysis of prepared microcapsules was done by a standard sieving method and in… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
6
0

Year Published

2011
2011
2018
2018

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 8 publications
(6 citation statements)
references
References 11 publications
0
6
0
Order By: Relevance
“…Nanocomposites based on nanocellulose, nano-or microfibrilliar cellulose, cellulose nanofibers are new generation nanomaterials possessing wide range of practical applications in such domains as pharmacology 1 and medicine 2 , tissue engineering [3][4][5] , biosensors 6 , microfluidics elements 7 , materials for microencapsulation 8 and drug delivery [9][10][11][12] , as permoselective membranes 13 , and as a barrier to protect mucosal tissues 14,15 . The nanoscale cellulose possesses a whole complex of unique properties typical for nanomaterials in general, such as high specific surface area, enhanced chemical reactivity, high mechanical durability, together with biocompatibility, biodegradability, and non-toxicity, which make it an excellent candidate for drug release applications.…”
Section: Introductionmentioning
confidence: 99%
“…Nanocomposites based on nanocellulose, nano-or microfibrilliar cellulose, cellulose nanofibers are new generation nanomaterials possessing wide range of practical applications in such domains as pharmacology 1 and medicine 2 , tissue engineering [3][4][5] , biosensors 6 , microfluidics elements 7 , materials for microencapsulation 8 and drug delivery [9][10][11][12] , as permoselective membranes 13 , and as a barrier to protect mucosal tissues 14,15 . The nanoscale cellulose possesses a whole complex of unique properties typical for nanomaterials in general, such as high specific surface area, enhanced chemical reactivity, high mechanical durability, together with biocompatibility, biodegradability, and non-toxicity, which make it an excellent candidate for drug release applications.…”
Section: Introductionmentioning
confidence: 99%
“…Samples were withdrawn at intervals of 30, 60 and 90 days as per ICH guidelines. Prepared formulations evaluated for drug content and dissolution 14 .…”
Section: Stability Studiesmentioning
confidence: 99%
“…This can be largely attributed to the lower permeability of EC films. 17 Another possible reason may be the occurrence of complex/non-covalent interactions of Ca 2þ with the hydroxyl groups of the EC polymer. 28 Such interactions might lead to the slower release of Ca 2þ from microcapsules with EC.…”
Section: 11mentioning
confidence: 99%
“…EC-based microcapsules show a slower drug release compared to other polymer-based microcapsules. [14][15][16][17] In addition, polymer blends have also been studied for drug release and showed superior properties to single polymer microcapsules. 11,14,16 This study was designed to develop a new type of biocompatible calcium hydroxide delivery system: calcium hydroxide-loaded microcapsules.…”
Section: Introductionmentioning
confidence: 99%