Preparation and in-vitro characterization of electrospun bioactive glass nanotubes as mesoporous carriers for ibuprofen

Panah, Neda Ghaebi; Alizadeh, Parvin; Yekta, B. Eftekhari; Motakef-Kazemi, Negar

doi:10.1016/j.ceramint.2016.03.228

Cited by 22 publications

(7 citation statements)

References 25 publications

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“…The textural properties of Ag-BG NPs determined from the nitrogen (N 2 ) adsorption and desorption isotherms were demonstrated in figure 3. Corresponding to the IUPAC the glass compositions were identified as type IV, which is descriptive of the mesoporous materials of 2−50 nm [28]. The hysteresis loop of this isotherm revealed different paths for desorption and adsorption branches at relatively high pressure P/P 0 .…”

Section: Textural Analysismentioning

confidence: 95%

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Antimicrobial properties of tissue conditioner containing silver doped bioactive glass nanoparticles:in vitrostudy

Moussa

El-Kady

Elboraey

et al. 2018

Adv. Nat. Sci: Nanosci. Nanotechnol.

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The objective of this work is to prepare and verify the antimicrobial properties of tissue conditioner containing silver doped bioactive glass nanoparticles (Ag-BG NPs) in vitro against three oral pathogens. A novel bioactive glass (BG) nanoparticles (NPs) with different Ag weight percentages of 0.6, 1.2, 3 and 4 wt% was prepared via a modified sol-gel method. Characterization of Ag-BG NPs was carried out using transmission electron microscopy (TEM), Fourier transformer infrared spectrophotometer (FTIR). Antimicrobial activities of the NPs were estimated. Also, Ag + ions release was measured using an inductively coupled plasma optical emission spectroscopy (ICP/OES). The 4% Ag-BG NPs was incorporated into the tissue conditioner (TC) for the preparation of the composite specimens (TC/Ag BG 4%). The dispersion of the NPs was evaluated using SEM/EDX. Ag + ion release and antimicrobial activities were evaluated. Finally, cell cytotoxicity was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay on normal human fibroblast (BJ1). Data analysis was performed using one-way ANOVA, and Tukey's post hoc test. The Ag-BG NPs (4%) exhibited the highest statistical significant mean inhibition value against selected pathogens. A novel Ag-BG NPs with antimicrobial properties with gradual release of Ag + were developed. However, the antimicrobial activity was lost when it was incorporated into the tissue conditioner.

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Section: Textural Analysismentioning

confidence: 95%

“…Corresponding to the IUPAC the glass compositions were identified as type IV, which is descriptive of the mesoporous materials of 2−50 nm [28]. The hysteresis loop of this isotherm revealed different paths for desorption and adsorption branches at relatively high pressure P/P 0 .…”

Section: Textural Analysismentioning

confidence: 99%

Antimicrobial properties of tissue conditioner containing silver doped bioactive glass nanoparticles:in vitrostudy

Moussa

El-Kady

Elboraey

et al. 2018

Adv. Nat. Sci: Nanosci. Nanotechnol.

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“…In 2004, Yan et al [13] developed a new type of SiO 2 -CaO-P 2 O 5 mesoporous bioactive glass (MBG) system. MBG has the advantages of excellent biocompatibility, bioactivity, and osteoconductivity, thus making itsuitable for bone regeneration and drug delivery [14,15]. In addition,the pore size distribution of MBG is on the nanoscale.…”

Section: Introductionmentioning

confidence: 99%

Amino-functionalized mesoporous bioactive glass for drug delivery

et al. 2017

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An amino-functionalized mesoporous bioactive glass (N-MBG) with a high drug loading capacity and longer drug release time was successfully prepared by using 3-aminopropyltriethoxysilane (APTES) in a short-time chemical reaction. The drug release performance of an MBG and the N-MBG were studied by loading gentamicin sulfate (GS) in a simulated body fluid solution. The results showed that the surface area of the N-MBG increases to 355.01 mg after amination at 80 °C for 1 h compared with that of the MBG (288.07 mg). Meanwhile, the surface zeta-potential of the N-MBG charges from the original negative charge (-10.06 mV) to the positive charge (+5.30 mV). Furthermore, the GS loading rate of the N-MBG is up to 62.92 ± 2.02%, higher than that of the MBG (48.90 ± 1.71%). In addition, the N-MBG has a longer drug release period and the seven-day accumulative release from the N-MBG reached only 45.9 ± 1.8%, significantly lower than that of the MBG, 60.7 ± 2.3%. In vitro bioactivity tests suggested that the N-MBG exhibited good biological activity. In conclusion, the N-MBG with a higher loading capacity and longer drug release time can serve as a promising candidate as a drug carrier.

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“…18,63 Ibuprofen was selected as a model molecule in this work since it is authentic and frequently used as an anti-inflammatory drug. 64–67 Furthermore, it has a lipophilic nature and convenient molecular size to be incorporated into the pores of the bioglass nanoparticles. 68…”

Section: Resultsmentioning

confidence: 99%

Acellular bioactivity and drug delivery of new strontium doped bioactive glasses prepared through a hydrothermal process

2022

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Preparation and in-vitro characterization of electrospun bioactive glass nanotubes as mesoporous carriers for ibuprofen

Cited by 22 publications

References 25 publications

Antimicrobial properties of tissue conditioner containing silver doped bioactive glass nanoparticles:in vitrostudy

Antimicrobial properties of tissue conditioner containing silver doped bioactive glass nanoparticles:in vitrostudy

Amino-functionalized mesoporous bioactive glass for drug delivery

Acellular bioactivity and drug delivery of new strontium doped bioactive glasses prepared through a hydrothermal process

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