Preparation and in vitro dissolution characteristics of propranolol microcapsules

Pongpaibul, Yanee; Whitworth, Clyde W.

doi:10.1016/0378-5173(86)90059-1

Cited by 21 publications

(5 citation statements)

References 11 publications

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“…In this case, the drug was able to modify the dimensional structure of EDGFS nanoparticles. Some researchers have pointed out that the viscosity of the dispersed phase can be related to the size distribution, where, often increasing the viscosity of the organic phase, the mean size also increases (Pongpaibul, Whitworth, 1986;Chong-Kook, Mi-Jung, Kyoung-Hee, 1994).…”

Section: The Size Distribution Pi and Zp Of The Polymeric Nanoparticlementioning

confidence: 99%

Novel Eudragit® -based polymeric nanoparticles for sustained release of simvastatin

Rodrigues

Couto

Sinisterra

et al. 2020

Braz. J. Pharm. Sci.

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This paper reports on the development of nanoparticles aiming at the in vitro controlled release of simvastatin (SVT). The nanoparticles were prepared by the nanoprecipitation method with polymers Eudragit ® FS30D (EDGFS) or Eudragit ® NE30D (EDGNE). EDGFS+SVT nanoparticles showed mean size of 148.8 nm and entrapment efficiency of 76.4%, whereas EDGNE+SVT nanoparticles showed mean size of 105.0 nm and entrapment efficiency of 103.2%. Infrared absorption spectra demonstrated that SVT incorporated into the polymer matrix, especially EDGNE. Similarly, the differential scanning calorimeter (DSC) curve presented no endothermic peak of fusion, indicating that the system is amorphous and the drug is not in the crystalline state. The maintenance of SVT in the amorphous state may favors its solubilization in the target release sites. In the in vitro dissolution assay, the SVT incorporated into the EDGFS+SVT nanoparticles showed a rapid initial release, which may be related to the pH of the dissolution medium used. Regarding the EDGNE+SVT nanoparticles, the in vitro release occurred in a bimodal behavior, i.e., an initial "burst" followed by a sustained delivery, with the kinetics of drug release following Baker-Lonsdale's mathematical model. All these features suggest the nanoparticulate system's potential to modulate SVT delivery and enhance its bioavailability.

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Section: The Size Distribution Pi and Zp Of The Polymeric Nanoparticlementioning

confidence: 99%

Novel Eudragit® -based polymeric nanoparticles for sustained release of simvastatin

Rodrigues

Couto

Sinisterra

et al. 2020

Braz. J. Pharm. Sci.

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“…On one hand, this can be attributed to the load exerted over the cubosomes to pack higher amounts of the drug. On the other hand, it may be a result of the increased viscosity of the aqueous phase which may hinder the fine distribution of the ultrasonic waves and prevent the homogenous NC dispersion resulting in a larger PS (Pongpaibul & Whitworth, 1986 ).…”

Section: Discussionmentioning

confidence: 99%

The efficacy ofOriganum majoranananocubosomal systems in ameliorating submandibular salivary gland alterations in streptozotocin-induced diabetic rats

et al. 2021

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Diabetes mellitus is a challenging health problem. Salivary gland dysfunction is one of its complications. Current treatments possess numerous adverse effects. Therefore, herbal extracts have emerged as a promising approach for safe and effective treatment. However, they are required in large doses to achieve the desired effect. Accordingly, Origanum majorana extract (OE) was incorporated into nano-sized systems to enhance its biological effects at lower dosages. OE was standardized against rosmarinic acid (RA) and then loaded into nano-cubosomal (NC) systems via a 2 3 full-factorial design. Two optimum nano-systems at different drug loads (2.08 or 1.04 mg-RA/mL) were selected and assessed in vivo to compare their effects in streptozotocin-induced diabetic rats against conventional OE (2.08 mg-RA/mL). Blood glucose was evaluated weekly. Submandibular salivary glands were processed for histopathological examination and nuclear factor-erythroid 2-related factor 2 ( Nrf2 ), Kelch-like ECH-associated protein 1 ( Keap1 ), and p38-MAPK gene expression analysis. NC systems were successfully prepared and optimized where the optimum systems showed nano-sized vesicles (210.4–368.3 nm) and high zeta potential values. In vivo results showed a significant lower blood glucose in all treated groups, with an exceptional reduction with NC formulations. Marked histopathological improvement was observed in all OE - treated groups, with OE-NC4 (2.08 mg-RA/mL) demonstrating the best features. This was supported by RT-PCR; where the OE-NC4 group recorded the highest mean value of Nrf2 and the least mean values of Keap1 and p38-MAPK , followed by OE-NC3 and OE groups. In conclusion, OE-loaded NC enhanced the anti-hyperglycemic effect of OE and ameliorated diabetic gland alterations compared to conventional OE. Thus, cubosomal nano-systems could be anticipated as potential carriers for the best outcome with OE.

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“…For example, Whitworth (Pongpaibul and Whitworth 1986b) carried out an early study on the formation of microparticles of propranolol in CAB-171-15. These investigators added a solution of polymer and drug in acetone to mineral oil.…”

Section: Matricesmentioning

confidence: 99%

Cellulose esters in drug delivery

Edgar

2006

Cellulose

171

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Cellulose esters have played a vital role in the development of modern drug delivery technology. They possess properties that are not only well-suited to the needs of pharmaceutical applications, but that enable construction of drug delivery systems that address critical patient needs. These properties include very low toxicity, endogenous and/or dietary decomposition products, stability, high water permeability, high T g , film strength, compatibility with a wide range of actives, and ability to form micro-and nanoparticles. This suite of properties has enabled the creation of a wide range of drug delivery systems employing cellulose esters as key ingredients. The following is a review of the most important types of these systems, and of the critical roles played by cellulose esters in making them work, focusing on more recent developments.

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Preparation and in vitro dissolution characteristics of propranolol microcapsules

Cited by 21 publications

References 11 publications

Novel Eudragit® -based polymeric nanoparticles for sustained release of simvastatin

Novel Eudragit® -based polymeric nanoparticles for sustained release of simvastatin

The efficacy ofOriganum majoranananocubosomal systems in ameliorating submandibular salivary gland alterations in streptozotocin-induced diabetic rats

Cellulose esters in drug delivery

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