Preparation and properties of thermo- and pH-responsive polypeptide bearing OEG and aldehyde pendants

Zhou, Congping; Shi, Zuowen; Xu, Fei; Ying, Lei; Tang, Haoyu

doi:10.1007/s00396-020-04712-6

Cited by 8 publications

(6 citation statements)

References 44 publications

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“…The second strategy is to manipulate the pH responsivity by attaching cleavable functional groups through pH‐labile linkers, which are designed to be stable at physiological pH, but undergoes cleavage when exposed to acidic condition. The pH‐labile linkers can be designed by selecting different pH‐responsible components including amide, [ 100 ] anhydride, [ 101 ] hydrazone, [ 102 ] acetal, [ 103 ] imine, [ 104 ] and ketal. [ 105 ] Another design strategy for controlling the pH responsivity is by changing the secondary structure of polypeptides, for example, α helices, β sheets, and coils, [ 106 ] which depend on pH‐responsive hydrophobic and ionic interactions.…”

Section: Ph‐responsive Biomoleculesmentioning

confidence: 99%

Design of Stimuli‐Responsive Peptides and Proteins

Yang

Gerstweiler

et al. 2022

Adv Funct Materials

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Stimuli‐responsive peptides and proteins are an exciting class of smart biomaterials for various applications and have received significant attention over the past decades. A wide variety of stimuli such as temperature, pH, ions, enzymes, magnetic field, redox, etc., are explored. This article provides a review of five intensively studied types of stimuli‐responsive peptides and proteins, their design principles and applications, including temperature‐, pH‐, light‐, metal ion‐, and enzyme‐responsive with an emphasis on the key design concepts and switch function. Moreover, typical examples of their applications are discussed to provide a better understanding of the design concept and underlying methodology. This review will facilitate and inspire future innovation toward new peptide‐ and protein‐based materials and their diverse applications.

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Section: Ph‐responsive Biomoleculesmentioning

confidence: 99%

Design of Stimuli‐Responsive Peptides and Proteins

Yang

Gerstweiler

et al. 2022

Adv Funct Materials

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“…Other pH-labile linkages, such as imine bonds, have also been investigated. Zhou et al reported the preparation of thermo- and pH-responsive poly(γ-4-(propargoxycarbonyl)benzyl-L-glutamate) co-grafted with oligoethylene glycol and aldehydes [ 71 ]. Cross-linking of the grafted aldehyde groups with 1,6-hexanediamine facilitated the formation of nanoparticles with pH-labile imine cross-links that could be reverted back to linear polymer chains below pH 6.15.…”

Section: Overview Of Ph-responsive Polypeptide and Polymer-peptidementioning

confidence: 99%

“…Cross-linking of the grafted aldehyde groups with 1,6-hexanediamine facilitated the formation of nanoparticles with pH-labile imine cross-links that could be reverted back to linear polymer chains below pH 6.15. The cross-linked polymer was water soluble at pH values above 6.15 and between 0–100 °C, but exhibited a reversible lower critical solution temperature (LCST) at pH values below 5.8 [ 71 ].…”

Section: Overview Of Ph-responsive Polypeptide and Polymer-peptidementioning

confidence: 99%

Strategies for the Development of pH-Responsive Synthetic Polypeptides and Polymer-Peptide Hybrids: Recent Advancements

et al. 2021

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Synthetic polypeptides and polymer-peptide hybrid materials have been successfully implemented in an array of biomedical applications owing to their biocompatibility, biodegradability and ability to mimic natural proteins. In addition, these materials have the capacity to form complex supramolecular structures, facilitate specific biological interactions, and incorporate a diverse selection of functional groups that can be used as the basis for further synthetic modification. Like conventional synthetic polymers, polypeptide-based materials can be designed to respond to external stimuli (e.g., light and temperature) or changes in the environmental conditions (e.g., redox reactions and pH). In particular, pH-responsive polypeptide-based systems represent an interesting avenue for the preparation of novel drug delivery systems that can exploit physiological or pathological pH variations within the body, such as those that arise in the extracellular tumour microenvironment, intracellularly within endosomes/lysosomes, or during tissue inflammation. Here, we review the significant progress made in advancing pH-responsive polypeptides and polymer-peptide hybrid materials during the last five years, with a particular emphasis on the manipulation of ionisable functional groups, pH-labile linkages, pH-sensitive changes to secondary structure, and supramolecular interactions.

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“…Moreover, ether oxygen also plays an important role for the design of temperatureresponsive polymers. For example, oligo(ethylene glycol) (OEG) containing ether oxygen was usually introduced for preparing temperature-responsive polymers, such as OEG methacrylate based polymers [39,40] and polypeptides bearing OEG pendants [41,42]. In 2021, linear alkyl ether-type amine compounds, which contain one ether oxygen and varying carbon atoms, were successfully used for the synthesis of temperature-responsive PAS-PAm derivatives bearing alkyl ether-type pendants [43].…”

Section: Temperature-responsive Poly(aspartamide) Derivativesmentioning

confidence: 99%

Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers

Zhang

Bao

2021

IJMS

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Poly(aspartamide) derivatives, one kind of amino acid-based polymers with excellent biocompatibility and biodegradability, meet the key requirements for application in various areas of biomedicine. Poly(aspartamide) derivatives with stimuli-responsiveness can usually respond to external stimuli to change their chemical or physical properties. Using external stimuli such as temperature and pH as switches, these smart poly(aspartamide) derivatives can be used for convenient drug loading and controlled release. Here, we review the synthesis strategies for preparing these stimuli-responsive poly(aspartamide) derivatives and the latest developments in their applications as drug carriers.

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Preparation and properties of thermo- and pH-responsive polypeptide bearing OEG and aldehyde pendants

Cited by 8 publications

References 44 publications

Design of Stimuli‐Responsive Peptides and Proteins

Design of Stimuli‐Responsive Peptides and Proteins

Strategies for the Development of pH-Responsive Synthetic Polypeptides and Polymer-Peptide Hybrids: Recent Advancements

Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers

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