Soft colloidal particles with multiple
surface patches of differing
composition are critical to the development of complex macroscopic
structures that can serve as interfacial catalysts, macroscale surfactants,
electronically responsive materials, and drug delivery vehicles. Here,
we present a continuous process for the scalable formation of soft
colloidal particles with multiple surface domains that employs well-established
principles of polymer precipitation and phase separation to controllably
shape particle architectures. Our results illustrate the broad range
of particle morphologies, including Janus and Cerberus structures,
and surface compositions accessible to our versatile solution-based
assembly system. We also identify polymer diffusion, precipitation,
and vitrification as the primary determinants of particle structure
for the first time.