Preparation, characterization and antibacterial properties of cyanoethylchitosan/cellulose acetate polymer blended films

Abou‐Zeid, N. Y.; Waly, A.; Kandile, Nadia G.; Rushdy, Abeer Ahmed; El-Sheikh, Manal A.; Ibrahim, Hassan M.

doi:10.1016/j.carbpol.2010.11.026

Cited by 76 publications

(54 citation statements)

References 33 publications

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“…The inclusion of organic and inorganic additives represents an effective route to the physical and mechanical modification of CA-based materials. [8][9][10][11][12][13] Long linear chain molecular polymers, such as poly (ethylene oxide) (PEO), are expected to impart high flexibility to the CA matrix. PEO is one of the most biocompatible synthetic polymers; it is approved by the Food and Drug Administration for safe use in foods and pharmaceuticals.…”

Section: Introductionmentioning

confidence: 99%

Effects of poly(ethylene oxide) and ZnO nanoparticles on the morphology, tensile and thermal properties of cellulose acetate nanocomposite fibrous film

Pittarate

Yoovidhya

Srichumpuang

et al. 2011

Polym J

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A bio-based fibrous film intended to be used as a food-packaging component was electrospun from blend solutions of cellulose acetate (CA) in neat acetic acid and poly(ethylene oxide) (PEO) in 90% ethanol. The CA/PEO blend ratios were varied to determine the effects of PEO on the morphology, moisture-adsorption and tensile properties of the blended fibrous films. Zinc oxide nanoparticles (ZnO NPs) incorporated (2-20 wt% of PEO) into the blended fibers were tested for their effect on tensile and thermal properties of the nanocomposite films. The results indicated that the addition of PEO at 9 wt% improved tensile strength, elongation and elasticity (Po0.05) of the CA-based fibrous films. The energy-dispersive spectrometer-scanning electron microscopy results suggested that zinc elements were well dispersed in the CA-PEO-blend fiber matrix. The addition of ZnO NPs at 20 wt% of PEO led to a significant improvement in the elongation and tensile strength of the CA-PEO-blend fibrous film (Po0.05). This improvement was attributed to the association between ZnO NPs and the semi-crystalline structures of the PEO, as evidenced by differential scanning calorimetry thermograms and X-ray diffraction spectra.

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Section: Introductionmentioning

confidence: 99%

Effects of poly(ethylene oxide) and ZnO nanoparticles on the morphology, tensile and thermal properties of cellulose acetate nanocomposite fibrous film

Pittarate

Yoovidhya

Srichumpuang

et al. 2011

Polym J

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“…59 Briefly, CS was dissolved in (1 wt%) acetic acid to form homogenous aqueous solution, afterward filtered by filter paper. The solution was neutralized with NaOH (1 M) solution with continuous stirring and the fine powder obtained was collected.…”

Section: Synthesis Of An-and Arg-modified Cs Conjugatementioning

confidence: 99%

Self-assembled nanoparticles based on amphiphilic chitosan derivative and arginine for oral curcumin delivery

Raja

Zeenat

Arif

et al. 2016

IJN

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Curcumin (Cur) is a striking anticancer agent, but its low aqueous solubility, poor absorption, hasty metabolism, and elimination limit its oral bioavailability and consequently hinder its development as a drug. To redress these limitations, amphiphilic chitosan (CS) conjugate with improved mucoadhesion and solubility over a wider pH range was developed by modification with hydrophobic acrylonitrile (AN) and hydrophilic arginine (Arg); the synthesized conjugate (AN–CS–Arg), which was well characterized by Fourier transform infrared and 1 H nuclear magnetic resonance spectroscopy. Results of critical aggregation concentration revealed that the AN–CS–Arg conjugate had low critical aggregation concentration and was prone to form self-assembled nanoparticles (NPs) in aqueous medium. Cur-encapsulated AN–CS–Arg NPs (AN–CS–Arg/Cur NPs) were developed by a simple sonication method and characterized for the physicochemical parameters such as zeta potential, particle size, and drug encapsulation. The results showed that zeta potential of the prepared NPs was 40.1±2.81 mV and the average size was ~218 nm. A considerable improvement in the aqueous solubility of Cur was observed after encapsulation into AN–CS–Arg/Cur NPs. With the increase in Cur concentration, loading efficiency increased but encapsulation efficiency decreased. The in vitro release profile exhibited sustained release pattern from the AN–CS–Arg/Cur NPs in typical biological buffers. The ex vivo mucoadhesion study revealed that AN–CS–Arg/Cur NPs had greater mucoadhesion than the control CS NPs. Compared with free Cur solution, AN–CS–Arg/Cur NPs showed stronger dose-dependent cytotoxicity against HT-29 cells. In addition, it was observed that cell uptake of AN–CS–Arg/Cur NPs was much higher compared with free Cur. Furthermore, the in vivo pharmacokinetic results in rats demonstrated that the AN–CS–Arg/Cur NPs could remarkably improve the oral bioavailability of Cur. Therefore, the developed AN–CS–Arg/Cur NPs might be a promising nano-candidate for oral delivery of Cur.

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“…In case of gram positive bacterium, the cell wall is fully composed of peptide polyglycogen and since the peptidoglycan layer is composed of networks with plenty of pores it allows the foreign molecules to come into the cell without difficulty. But in case of gramnegative bacterium, since the cell wall is made up of a thin membrane of peptide polyglycogen and an outer membrane constituted of lipopolysaccharide, lipoprotein and phospholipids which is a bilayer, it acts as a potential barrier against foreign molecules to enter into cell wall [65][66][67][68].…”

Section: Antibacterial Activitymentioning

confidence: 99%

Synthesis, Characterization and Applications of Nanochitosan/Sodium Alginate/Microcrystalline Cellulose Film

Vijayalakshmi¹,

Bm²,

PN³

et al. 2016

J Nanomed Nanotechnol

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The antimicrobial potential of the synthesized ternary nanochitosan (NCS)/sodium alginate (SA)/microcrystalline cellulose (MC) (extracted from banana fiber) film in 4:16:1 ratio against Bascillus subtilis and E. coli are reported here. Initially the present work focuses on the synthesis and characterization of ternary nanochitosan (NCS)/sodium alginate (SA)/microcrystalline cellulose (MC) (extracted from banana fiber) film. The prepared NCS/SA/MC film sample was then characterized using advanced analytical techniques such as FT-IR, XRD, TGA, DSC and SEM studies. The obtained results of FT-IR studies clearly indicate that the nanochitosan gets effectively binded with the sodium alginate and the microcrystalline cellulose in the film form. The change in crystallinity and the increased thermal behavior was elucidated from XRD and TGA analysis respectively. The scanning electron microscopic (SEM) studies of NCS/SA/MC film showed that the prepared film has the improved rough surface morphology and fractured structure. The bactericidal action of NCS/SA/MC film determined using Muller Hinton Agar medium on two microbial strains (Escherichia coli and Bacillus subtilis) reveals that the prepared NCS/SA/MC film has the greater potential to kill the microorganisms to a greater extent and hence this NCS/SA/MC film was found to be suggested as the promising material for biomedical applications.

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Preparation, characterization and antibacterial properties of cyanoethylchitosan/cellulose acetate polymer blended films

Cited by 76 publications

References 33 publications

Effects of poly(ethylene oxide) and ZnO nanoparticles on the morphology, tensile and thermal properties of cellulose acetate nanocomposite fibrous film

Effects of poly(ethylene oxide) and ZnO nanoparticles on the morphology, tensile and thermal properties of cellulose acetate nanocomposite fibrous film

Self-assembled nanoparticles based on amphiphilic chitosan derivative and arginine for oral curcumin delivery

Synthesis, Characterization and Applications of Nanochitosan/Sodium Alginate/Microcrystalline Cellulose Film

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