Preparation, Characterization and In vitro Evaluation of Theophylline Nanoparticles Prepared with Dextran- Conjugated Soy Protein

Jin, Bei; Zhou, Xiaosong; Chen, Caiyan; Zhang, Xiaosa; Chen, Siqiao

doi:10.4314/tjpr.v14i8.2

Cited by 9 publications

(4 citation statements)

References 21 publications

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“…Pada pemberian oral, stabilitas teofilin mudah berubah oleh adanya pengaruh enzim, pH, dan degradasi mikroba [4]. Teofilin juga diketahui dapat menyebabkan gangguan saluran cerna seperti indigesti [5] sehingga tidak heran jika senyawa ini mulai banyak dikaji dan dikembangkan sistem penghantarannya ke dalam mikropartikel [6], hydrogel [7], dan nanopartikel [8].…”

Section: Introductionunclassified

Penerapan Teknik Nanopresipitasi pada Nanoenkapsulasi Teofilin dengan Variasi Konsentrasi Polimer dan Surfaktan

2023

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Teofilin merupakan derivat xantin yang digunakan dalam terapi asma yang menyebabkan relaksasi otot polos, khususnya dilatasi otot polos bronkus. Sejauh ini bentuk sediaan farmasi teofilin sangat beragam dan sebagian besar ditujukan untuk penggunaan secara oral. Pemberian obat peroral diketahui rentan menyebabkan gangguan saluran cerna seperti indigesti. Selain itu, stabilitasnya juga mudah berubah karena adanya pengaruh enzim, pH, dan degradasi mikroba. Salah satu sistem penghantaran obat yang menjanjikan adalah nanoenkapsulasi. Tujuan dari penelitian ini adalah untuk memperoleh formula optimum dari nanoenkapsulasi teofilin (NET) menggunakan sistem optimasi. Nanoenkapsulasi teofilin dipreparasi dengan menerapkan variasi konsentrasi PEG 6000 dan SLS mulai dari perbandingan terkecil 1:1 hingga terbesar 3:1. Adapun karakterisasi yang dilakukan terhadap lima formula NET meliputi persentase transmitan, ukuran partikel, dan indeks polidispersitas (PDI). Formula optimum NET terpilih kemudian ditetapkan zeta potensialnya menggunakan Particle Size Analyzer. Perbandingan antara PEG 6000 dan SLS sebesar 1,667:1 merupakan komposisi paling optimum yang mampu menghasilkan NET dengan ukuran partikel 11,9 nm, PDI 0,12 µm, dan zeta potensial sebesar +18,87 mV.

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Section: Introductionunclassified

Penerapan Teknik Nanopresipitasi pada Nanoenkapsulasi Teofilin dengan Variasi Konsentrasi Polimer dan Surfaktan

2023

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“…Therefore, SPI, a natural plant protein with good emulsifying properties, and dextran (Dex), a neutral polysaccharide with excellent solubility and biocompatibility, were selected for investigation in this study. 23 Furthermore, it is still unknown whether SPI-Dex complexes can stabilize HIPEs. The effect of Dex concentration on the HIPEs stabilized by SPI-Dex complexes is also not clear.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the interaction mechanism between proteins and uncharged polysaccharides is still not clear, especially regarding SPI. Therefore, SPI, a natural plant protein with good emulsifying properties, and dextran (Dex), a neutral polysaccharide with excellent solubility and biocompatibility, were selected for investigation in this study 23 . Furthermore, it is still unknown whether SPI–Dex complexes can stabilize HIPEs.…”

Section: Introductionmentioning

confidence: 99%

Development of high‐internal‐phase emulsions stabilized by soy protein isolate–dextran complex for the delivery of quercetin

Liu

et al. 2022

J Sci Food Agric

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Background: Protein-polysaccharide complexes have been widely used to stabilize high-internal-phase emulsion (HIPEs). However, it is still unknown whether soy protein isolate-dextran (SPI-Dex) complexes can stabilize HIPEs or what is the effect of Dex concentration on the HIPEs. Furthermore, the non-covalent interaction mechanism between SPI and Dex is also unclear. Therefore, we fabricated SPI-Dex complexes and used them to stabilize HIPEs-loaded quercetin and explore the interaction mechanism between SPI and Dex, as well as the effect of Dex concentration on the particle size, ζ-potential, microstructure, rheology, quercetin encapsulation efficiency, and gastrointestinal fate of the HIPEs.Results: Spectral analysis (fourier transform infrared spectroscopy, ultraviolet spectroscopy, and fluorescence spectroscopy) results identified the formation of SPI-Dex complexes, and indicated that the addition of Dex changed the spatial structure of SPI, whereas thermodynamic analysis (ΔH > 0, ΔS > 0) showed that hydrophobic interactions were the main driving forces in the formation of SPI-Dex complexes. Compared with HIPEs stabilized by SPI, the SPI-Dex complex-stabilized HIPEs had smaller particles (3000.33 ± 201.22 nm), as well as higher ζ-potential (−21.73 ± 1.10 mV), apparent viscosities, modulus, and quercetin encapsulation efficiency (98.19 ± 0.14%). In addition, in vitro digestion revealed that SPI-Dex complex-stabilized HIPEs significantly reduced the release of free fatty acid and improved quercetin bioaccessibility. Conclusion: HIPEs stabilized by SPI-Dex complexes delayed the release of free fat acid and improved the bioaccessibility of quercetin, and may be help in designing delivery systems for bioactive substances with specific properties.

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“…Therefore, it seems that soy protein and dextran are ideal candidates for preparing bioactive compound nanocarriers. We have previously developed a simple and green method to fabricate nanoparticles with dextran-conjugated soy protein by TiO 2 photocatalysis [12]. However the particle size of the nanoparticles was too large to deliver functional materials with longer circulation time in vivo .…”

Section: Introductionmentioning

confidence: 99%

Self-Assembled Modified Soy Protein/Dextran Nanogel Induced by Ultrasonication as a Delivery Vehicle for Riboflavin

Jin

Zhou

et al. 2016

Molecules

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A simple and green approach was developed to produce a novel nanogel via self-assembly of modified soy protein and dextran, to efficiently deliver riboflavin. First, modified soy protein was prepared by heating denaturation at 60˝C for 30 min or Alcalase hydrolysis for 40 min. Second, modified soy protein was mixed with dextran and ultrasonicated for 70 min so as to assemble nanogels. The modified soy protein-dextran nanogels were characterized by Fourier-transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) and ζ-potential studies to confirm the formation of NGs. Transmission electron microscopy (TEM) revealed the NGs to be spherical with core-shell structures, in the range of 32-40 nm size. The nanogels were stable against various environmental conditions. Furthermore, the particle size of the nanogels hardly changed with the incorporation of riboflavin. The encapsulation efficiency of nanogels was found to be up to 65.9% at a riboflavin concentration of 250 µg/mL. The nanogels exhibited a faster release in simulated intestine fluid (SIF) compared with simulated gastric fluid (SGF). From the results obtained it can be concluded that modified soy protein-dextran nanogels can be considered a promising carrier for drugs and other bioactive molecule delivery purposes.

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Preparation, Characterization and In vitro Evaluation of Theophylline Nanoparticles Prepared with Dextran- Conjugated Soy Protein

Cited by 9 publications

References 21 publications

Penerapan Teknik Nanopresipitasi pada Nanoenkapsulasi Teofilin dengan Variasi Konsentrasi Polimer dan Surfaktan

Penerapan Teknik Nanopresipitasi pada Nanoenkapsulasi Teofilin dengan Variasi Konsentrasi Polimer dan Surfaktan

Development of high‐internal‐phase emulsions stabilized by soy protein isolate–dextran complex for the delivery of quercetin

Self-Assembled Modified Soy Protein/Dextran Nanogel Induced by Ultrasonication as a Delivery Vehicle for Riboflavin

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