Preparation of bovine hemoglobin-imprinted polymer beads via the photografting surface-modified method

Gai, Qingqing; Qiu-Ye, Liu; Li, Wen‐You; He, Xiwen; Chen, Langxing; Zhang, Yukui

doi:10.1007/s11458-008-0089-x

Cited by 8 publications

(5 citation statements)

References 27 publications

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“…Consequently, computational chemistry can be an ally to optimize the process and keep away from unwanted elements. 38 For this goal, the three most experimentally used crosslinking agents, divinylbenzene (DVB), 48 N,N-methylene bisacrylamide (NNMB), [49][50][51] and ethylene glycol dimethacrylate (EGDMA), 48 were chosen and examined under the identical conditions as the monomer simulations.…”

Section: δE = Ementioning

confidence: 99%

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Theoretical design of molecularly imprinted polypyrrole biosensor for the detection of renal failure biomarkers

Rajaee,

Izadyar,

Housaindokht

2023

Mol. Syst. Des. Eng.

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Section: δE = Ementioning

confidence: 99%

“…For this goal, the three most experimentally used cross-linking agents, divinylbenzene (DVB), 48 N , N -methylene bisacrylamide (NNMB), 49–51 and ethylene glycol dimethacrylate (EGDMA), 48 were chosen and examined under the identical conditions as the monomer simulations.…”

Section: Theory and Computational Detailsmentioning

confidence: 99%

Theoretical design of molecularly imprinted polypyrrole biosensor for the detection of renal failure biomarkers

Rajaee,

Izadyar,

Housaindokht

2023

Mol. Syst. Des. Eng.

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“…Thus, the next step was the analysis of the proper crosslinking agent. For this goal, the three most experimentally used cross-linking agents N,N-methylene bisacrylamide (NNMB) [48][49][50], trimethylolpropane trimethacrylate (TRIM) [51][52][53] and ethylene glycol dimethacrylate (EGDMA) [23,26,[54][55][56][57] were chosen. It should be kept in mind that EGDMA is the most commonly employed.…”

Section: Selection Of Proper Cross-linking Agentmentioning

confidence: 99%

Computational design of synthetic receptors for drug detection: interaction between molecularly imprinted polymers and MDMA (3,4-methylenedioxymethamphetamine)

Sales

Ramalho

2020

Theor Chem Acc

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For many decades, synthetic receptors have been used as sensor elements and are a promising alternative to natural receptors, which, despite its great selectivity, are so complex and instable. The rational design of this kind of receptors is currently one of the most researched topics in molecular recognition. Molecular imprinted polymers (MIPs) have become a growing highlight in polymer chemistry, once they possess a wide range of applications and can be used in several environments, due to their high chemical and thermal stability. The aim of this study was to perform a rational design for the MIP preparation, for 3,4-methylenedioxymethamphetamine (MDMA) detection. The theoretical measurements were employed at several stages of the process, using DFT and B3LYP/6-31G(d,p) level of theory, by means of optimization and frequency calculations. Among the several functional monomers tested, the itaconic acid was the most appropriated for MIP preparation with MDMA template, and the proper molar ratio found theoretically was 3:1 (itaconic acid/MDMA). In the preparation of pre-polymerization complex, polar solvents were found to perform a better stabilization, mainly those which are not protic solvents. As cross-linking agents, the better results were obtained for trimethylolpropane trimethacrylate and ethylene glycol dimethacrylate molecules, respectively. Finally, selectivity tests showed a high affinity of the studied MIP for MDMA and chemically similar molecules. The proposal theoretical strategy yielded novel, experimentally testable hypotheses for the design of MIPs. Additionally, from the theoretical point of view, the set of computational analyses presented in this paper constitutes a very useful protocol to predict optimal experimental conditions, which can considerably reduce the time and cost on the MIPs preparation.

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“…A brief synopsis of the different types of protein and biomacromolecular surface‐imprinted monoliths and particles/beads is shown in Tables and , respectively, including the various surface imprinting strategies and characterization techniques that have been utilized.…”

Section: Imprinting Of Peptides and Proteins For The Use In Solid‐phamentioning

confidence: 99%

Advances in the development of molecularly imprinted polymers for the separation and analysis of proteins with liquid chromatography

Boysen

2018

J of Separation Science

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This review documents recent advances in the design, synthesis, characterization, and application of molecularly imprinted polymers in the form of monoliths and particles/beads for the use in the separation and analysis of proteins with solid‐phase extraction or liquid chromatography. The merits of three‐dimensional molecular imprinting, whereby the molecular template is randomly embedded in the polymer, and two‐dimensional imprinting, in which the template is confined to the surface, are described. Target protein binding can be achieved by either using the entire protein as a template or by using a protein substructure as template, that is, a peptide, as in the "epitope" approach. The intended approach and strategy then determine the choice of polymerization method. A synopsis has been provided on methods used for the physical, chemical, and functional characterizations and associated performance evaluations of molecularly imprinted and nonimprinted control polymers, involving a diverse range of analytical techniques commonly used for low and high molecular mass analytes. Examples of recent applications demonstrate that, due to the versatility of imprinting methods, molecularly imprinted monoliths or particles/beads can be adapted to protein extraction/depletion and separation procedures relevant to, for example, protein biomarker detection and quantification in biomedical diagnostics and targeted proteomics.

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Preparation of bovine hemoglobin-imprinted polymer beads via the photografting surface-modified method

Cited by 8 publications

References 27 publications

Theoretical design of molecularly imprinted polypyrrole biosensor for the detection of renal failure biomarkers

Theoretical design of molecularly imprinted polypyrrole biosensor for the detection of renal failure biomarkers

Computational design of synthetic receptors for drug detection: interaction between molecularly imprinted polymers and MDMA (3,4-methylenedioxymethamphetamine)

Advances in the development of molecularly imprinted polymers for the separation and analysis of proteins with liquid chromatography

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