Preparation of budesonide/γ‐cyclodextrin complexes in supercritical fluids with a novel SEDS method

Preparation of inclusion complex of piroxicam with cyclodextrin by using supercritical carbon dioxide

“…Drug References geraniol, mustard oil [12] acetaminophen [13] piroxicam [14,15] miconazole [15,16,17,18,19,20] Eflucimibe [21,22] ibuprofen [23,24,25,26,27,28,29] naproxen [28,30,31,32] flurbiprofen [28] citral, thymol, carvacrol [33] imazalil [34] salicylic acid [35] azobenzene [36] budesonide [37,38,39] indomethacin [40] polyaniline [41] cholesterol [42] arylphosphines [43] itraconazole [44,45,46] 2 sodium salts [47] hydroxyflavone [48] benzocaine [50, 49,] bupivacaine, and mepivacaine [50] simvastatin [51] several triphenyl phosphine derivatives [52] all-trans-lycopene [53] 15 carbohydrates [54] human serum immunoglobulin G …”

Crystal Structure Changes of γ-cyclodextrin After the SEDS Process in Supercritical Carbon Dioxide Affect the Dissolution Rate of Complexed Budesonide

“…The SEDS apparatus and processes have recently been described in our previous work (15). In the present study, solid g-CD particles were prepared with the conventional SEDS method.…”

“…In our previous work, we described a novel method for preparation of budesonide/g-CD complexes by using the solution enhanced dispersion by supercritical fluids (SEDS) process (15). The aim of the present study was to clarify the effect of the SEDS processing conditions on the properties of g-CD particles and to further discuss the effect of crystal structure changes of g-CD, induced by the SEDS process, on the dissolution rate of complexed model drug (budesonide).…”

Preparation of Emodin‐Polyethylene Glycol Composite Microparticles Using a Supercritical Antisolvent Process

“…Solution-enhanced dispersion by supercritical fluids (SEDS) is one of the SFP processes that have attracted high attention in producing high-quality drug composite microparticles. Some successful examples include: composite crystals of acetaminophen and p-acetoxyacetanilide [6], budesonide-b-cyclodextrin complexes [7], microencapsulation of amoxicillin in poly(L-lactic acid) [8], 5-fluorouracil-poly-(L-lactide) microparticles [9], budesonide-c-cyclodextrin complexes [10], etc. In our previous works, the SEDS-prefilming atomization (PA) process has been also successfully applied to deposit the composite microparticles of polyethylene glycol (PEG) loaded with natural carotene [2] and caroteneproanthocyanidin composite microparticles [11].…”