Preparation of chitosan-sodium alginate/bioactive glass composite cartilage scaffolds with high cell activity and bioactivity

Zhang, Wenpu; Hou, Xinghui; Wang, Huili; Kong, Dezhi; Zhou, Ying

doi:10.1016/j.ceramint.2022.09.164

Cited by 9 publications

(7 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They are present in different configurations: fibers, membranes, hydrogels, capsules, nanostructures, micelles, etc. The biopolymers that have been more prevalent in recent years include chitosan (CHT) and alginate (ALG), which have been widely applied for wound healing and other skin issues [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Alginate–Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing

et al. 2023

View full text Add to dashboard Cite

Biopolymers such as chitosan (CHT) or alginate (ALG) are among the most prominent for health-related applications due to their broad bioactivity. Their combination for the preparation of membranes is hereby proposed as an application for wound healing with the incorporation of lavender essential oil (LEO), widely known for its antioxidant and antimicrobial properties. The preparation of CHT, CHT + LEO, ALG, ALG + LEO, and CHT/ALG + LEO membranes was accomplished, and its composition was analyzed using Fourier Transform Infrared Spectroscopy (FTIR). The water absorption capacity and oil release profile of the membranes revealed higher water uptake capacity when a lower LEO release was obtained. The combined CHT/ALG + LEO film showed a water uptake percentage of 638% after 48 h and a maximum LEO release concentration of 42 mg/L. Cytotoxicity and biocompatibility of the prepared membranes were studied using a HaCaT cell line, with an assessment of cell viability regarding film leachables, DNA quantification, and DAPI-phalloidin staining. The results revealed that the indirect contact of the prepared membranes via its leachables does not compromise cell viability, and upon direct contact, cells do not adhere or proliferate on the surface of the membranes. Moreover, the CHT/ALG + LEO membrane increases cell proliferation, making it suitable for applications in wound healing.

show abstract

Section: Introductionmentioning

confidence: 99%

Alginate–Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing

et al. 2023

View full text Add to dashboard Cite

show abstract

“…This novel method offers a viable treatment option for articular cartilage abnormalities in knee joints. 81 Some of the effective formulations used to synthesize different nanocarriers for cartilage tissue engineering include Marine Coll-CS-fucoidan/chondroitin sulfate loaded with primary human cell, 82 CS/polydroxy butyrate/halloysite nanotubes, CS/PEG silicotugstic acid synthesized using smashed gel combination, 83 CS/poly(L-glutamic acid) hydrogel, 84 CS/sodium alginate/bioactive glass, 85 CMCS/g-poly-glutamic acid/ nanoHXP, 86 CS/CL NPs/HXP. 87…”

Section: Cs In Cartilage Tissue Engineeringmentioning

confidence: 99%

Chitosan alchemy: transforming tissue engineering and wound healing

Pramanik,

Aggarwal,

Kadi

et al. 2024

RSC Adv.

View full text Add to dashboard Cite

show abstract

“…Tissue engineering, a multifaceted process aimed at replacing damaged organs, entails restoring various biological functions (Amiryaghoubi et al, 2022). In this context, biomaterial-based scaffold has been developed to support cell adhesion, growth, and determine compatibility with the body (Zhang et al, 2023). An ideal scaffold for tissue engineering applications should have optimal chemical and structural characteristics along with good mechanical properties (Jafari et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Physical and Chemical Characterization of Collagen/Alginate/Poly(Vinyl Alcohol) Scaffold with the Addition of Multi-Walled Carbon Nanotube, Reduced Graphene Oxide, Titanium Dioxide, and Zinc Oxide Materials

Fajarani,

Rahman,

Pangesty

et al. 2024

IJTech

View full text Add to dashboard Cite

Bone damage is one of the main causes of disability in humans, and tissue engineering technology by applying biomaterial-based scaffold has been developed as an effective solution. This can be achieved using various natural and synthetic polymers combined with carbon-based and metal-oxide materials. Therefore, this study aimed to develop bone scaffold using collagen, alginate, and poly(vinyl alcohol), with the addition of multi-walled carbon nanotube, reduced graphene oxide, titanium dioxide, and zinc oxide materials. Scaffold was fabricated with the freeze-drying method and characterized physicochemically by observing the morphology through scanning electron microscopy (SEM), identification of functional groups by Fourier transform infrared spectroscopy (FTIR), compressive mechanical properties, porosity, and degradation rate. The results showed that each group of scaffold had a compact structure, with a small pore size and less than 50% porosity. The functional groups of each material were detected, and the compressive strength matched the trabecular bone, approximately 6 MPa. However, the scaffold lacked appropriate porosity and a fast degradation rate exceeding 35% in 7 days.

show abstract

Preparation of chitosan-sodium alginate/bioactive glass composite cartilage scaffolds with high cell activity and bioactivity

Cited by 9 publications

References 60 publications

Alginate–Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing

Alginate–Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing

Chitosan alchemy: transforming tissue engineering and wound healing

Physical and Chemical Characterization of Collagen/Alginate/Poly(Vinyl Alcohol) Scaffold with the Addition of Multi-Walled Carbon Nanotube, Reduced Graphene Oxide, Titanium Dioxide, and Zinc Oxide Materials

Contact Info

Product

Resources

About