Preparation of Egg Albumin Microcapsules and Microspheres

Ishizaka, Tomomichi; Endo, Kenji; Koishi, Masumi

doi:10.1002/jps.2600700404

Cited by 60 publications

(26 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Egg albumin has been used for the microencapsulation of drugs. These included the capillary extrusion method (denaturation by dispersion of drug-egg albumin solution into hot oil), w/o emulsion method (physical denaturation of the emulsified oildrug-egg albumin with different temperature), and chemical method using glutaraldehyde (28)(29)(30)(31)(32). In another study, a w 1 /o/w 2 emulsion solvent evaporation method was employed to encapsulate hydrophilic peptide into microspheres.…”

Section: Peo11mentioning

confidence: 99%

Solubility of Drugs in Aqueous Polymeric Solution: Effect of Ovalbumin on Microencapsulation Process

2011

View full text Add to dashboard Cite

Abstract. Microencapsulation of water-soluble drugs using coacervation-phase separation method is very challenging, as these drugs partitioned into the aqueous polymeric solution, resulting in poor drug entrapment. For evaluating the effect of ovalbumin on the microencapsulation of drugs with different solubility, pseudoephedrine HCl, verapamil HCl, propranolol HCl, paracetamol, and curcuminoid were used. In addition, drug mixtures comprising of paracetamol and pseudoephedrine HCl were also studied. The morphology, encapsulation efficiency, particle size, and in vitro release profile were investigated. The results showed that the solubility of the drug determined the ratio of ovalbumin to be used for successful microencapsulation. The optimum ratios of drug, ovalbumin, and gelatin for water-soluble (pseudoephedrine HCl, verapamil HCl, and propranolol HCl), sparingly water-soluble (paracetamol), and waterinsoluble (curcuminoid) drugs were found to be 1:1:2, 2:3:5, and 1:3:4. As for the drug mixture, the optimum ratio of drug, ovalbumin, and gelatin was 2:3:5. Encapsulated particles prepared at the optimum ratios showed high yield, drug loading, entrapment efficiency, and sustained release profiles. The solubility of drug affected the particle size of the encapsulated particle. Highly soluble drugs resulted in smaller particle size. In conclusion, addition of ovalbumin circumvented the partitioning effect, leading to the successful microencapsulation of water-soluble drugs.

show abstract

Section: Peo11mentioning

confidence: 99%

Solubility of Drugs in Aqueous Polymeric Solution: Effect of Ovalbumin on Microencapsulation Process

2011

View full text Add to dashboard Cite

show abstract

“…A wide variety of processes have been developed to prepare these protein-based micro (sub-micro) particles. The most common techniques are spray-drying (Bruschi, Cardoso, Lucchesi, & Gremiao, 2003), emulsifying-crosslinking (Ishizaka & Koishi, 1981) or coacervation (Mauguet et al, 2002). However, these techniques require heating or organic agents in at least one of the production steps, leading to some destruction of sensitive encapsulated nutrients as well as toxicity problems associated with residual organic agents (Birnbaum, Kosmala, Henthorn, & BrannonPeppas, 2000).…”

Section: Introductionmentioning

confidence: 98%

Whey protein capsules obtained through electrospraying for the encapsulation of bioactives

López‐Rubio

Lagarón

2012

Innovative Food Science & Emerging Technologies

217

View full text Add to dashboard Cite

“…In the preliminary experiments, heat coagulation methods suggested by Deasy (1984) and Ishizaka et al (1981) were employed for egg albumin. Other modifications included the stirrer, stirring speed, mix-cell and core to coat ratio.…”

Section: Preparation Of Microspheresmentioning

confidence: 99%

“…Albumin has several properties which make it an attractive choice as a carrier (Tomlinson 1983, Poznansky andCleland 1980). The denaturation of albumin has been attained by heat coagulation (Deasy 1984, Ishizaka et al 1981, Ishizaka and Koishi 1983 and/or by treatment with formalin (Widder et al 1979(Widder et al ,1982, 2,3-butadione (Widder et al 1979,1982, Burger et al 1985 or glutaraldehyde (Burger et al 1985, Lee et al 1981, Davis et a/. 1987, Ratcliffe et al 1984.…”

Section: Introductionmentioning

confidence: 98%

Drug targeting using non-magnetic and magnetic albumin-globulin mix microspheres of mefenamic acid

Lalla¹,

Ahuja²

1991

Journal of Microencapsulation

View full text Add to dashboard Cite

Optimum conditions for the preparation of non-magnetic and magnetic microspheres of albumin-globulin mix (alglomix) containing mefenamic acid have been standardized. The effect of various parameters has been investigated with regard to the appearance, yield, drug content and encapsulation efficiency. The physicochemical parameters of the microspheres such as density, particle size distribution, surface topography and wall thickness, as well as the magnetite contained within the magnetic microspheres, have been determined. The infrared spectroscopic analysis confirmed the encapsulation of the drug and absence of free drug on the surface of the microspheres. The X-ray diffraction analysis confirmed that the crystallinity of the drug remained unchanged indicating thereby that no complex formation had taken place between core and coat materials. The in vitro release profiles of the microspheres have been studied. An attempt has also been made to check the in vivo efficacy in rats.

show abstract

Preparation of Egg Albumin Microcapsules and Microspheres

Cited by 60 publications

References 10 publications

Solubility of Drugs in Aqueous Polymeric Solution: Effect of Ovalbumin on Microencapsulation Process

Solubility of Drugs in Aqueous Polymeric Solution: Effect of Ovalbumin on Microencapsulation Process

Whey protein capsules obtained through electrospraying for the encapsulation of bioactives

Drug targeting using non-magnetic and magnetic albumin-globulin mix microspheres of mefenamic acid

Contact Info

Product

Resources

About