Preparation of hybrid biomaterials for bone tissue engineering

Abstract

Tissue engineering has evolved from the use of biomaterials for bone substitution that fulfill the clinical demands of biocompatibility, biodegradability, non-immunogeneity, structural strength and porosity. Porous scaffolds have been developed in many forms and materials, but few reached the need of adequate physical, biological and mechanical properties. In the present paper we report the preparation of hybrid porous polyvinyl alcohol (PVA)/bioactive glass through the sol-gel route, using partially and fully hydrolyzed polyvinyl alcohol, and perform structural characterization. Hybrids containing PVA and bioactive glass with composition 58SiO2-33CaO-9P2O5 were synthesized by foaming a mixture of polymer solution and bioactive glass sol-gel precursor solution. Sol-gel solution was prepared from mixing tetraethoxysilane (TEOS), triethylphosphate (TEP), and calcium chloride as chemical precursors. The hybrid composites obtained after aging and drying at low temperature were chemically and morphologically characterized through infrared spectroscopy and scanning electron microscopy. The degree of hydrolysis of PVA, concentration of PVA solution and different PVA-bioglass composition ratios affect the synthesis procedure. Synthesis parameters must be very well combined in order to allow foaming and gelation. The hybrid scaffolds obtained exhibited macroporous structure with pore size varying from 50 to 600 µm

Rice husk derived bioactive glass-ceramic as a functional bioceramic: Synthesis, characterization and biological testing

“…The band at 932 cm − 1 corresponds to the Si-O-Si vibration (silanol groups in pure silica), which disappeared for the tested sample after the bioactivity evaluation due to the formations of an HCA layer. This finding is in agreement with the previous report [33].…”

“…These bands are similar to the reported data for hybrid PVA/bioactive glass described by Costa V.C. et al [33]. The band at 932 cm − 1 corresponds to the Si-O-Si vibration (silanol groups in pure silica), which disappeared for the tested sample after the bioactivity evaluation due to the formations of an HCA layer.…”

Biodegradable poly(vinyl alcohol)/polyoxalate electrospun nanofibers for hydrogen peroxide-triggered drug release

“…Pure PVA (curve a) showed a broad peak at 3100-3600 cm −1 which corresponds to a stretching of -OH group in PVA. [26,28] In the case of the spectrum of PVA/POX NFs with different ratios, the main characteristic peaks of POX (C=O bond stretching) appeared in all PVA/POX NFs (curves c-g). It was found that POX is present in electrospun nanofibers.…”

3D bioprinting for tissue engineering: Stem cells in hydrogels

“…However, natural materials often lack the mechanical integrity required whilst synthetic materials are often not biocompatible [50] . Some researchers have sought to overcome these issues by combining favourable elements from both categories to create hybrid materials [51,52] . Even so, not all of these materials are suited to 3D printing.…”