Preparation of Metal–Organic Frameworks UiO-66 for Adsorptive Removal of Methotrexate from Aqueous Solution

Aghajanzadeh, Mozhgan; Zamani, Mostafa; Molavi, Hossein; Manjili, Hamidreza Khieri; Shojaei, Akbar

doi:10.1007/s10904-017-0709-3

Cited by 165 publications

(67 citation statements)

References 43 publications

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“…Folate receptors are overexpressed on the cell membranes of many cancer cells . Methotrexate (MTX), an analog of folic acid (FA), disturbs cellular folate metabolism by inhibiting dihydrofolate reductase (DHFR), its target enzyme . The MTX shows not only a targeting role for folate receptors but also a therapeutic effect to many types of cancer cells that overexpress folate receptors on their surfaces .…”

Section: Introductionmentioning

confidence: 99%

“…[23][24][25] Methotrexate (MTX), an analog of folic acid (FA), disturbs cellular folate metabolism by inhibiting dihydrofolate reductase (DHFR), its target enzyme. 26,27 The MTX shows not only a targeting role for folate receptors but also a therapeutic effect to many types of cancer cells that overexpress folate receptors on their surfaces. 28,29 For to be effective, the drug carrier must be appropriately small to penetrate the vessels, perfuse out of the bloodstream, and set foot on the target cell of interest.…”

Section: Introductionmentioning

confidence: 99%

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Enzymatic stimuli‐responsive methotrexate‐conjugated magnetic nanoparticles for target delivery to breast cancer cells and release study in lysosomal condition

Nosrati

Mojtahedi

Danafar

et al. 2018

J Biomedical Materials Res

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In this study, magnetic nanoparticles (MNPs) coated with glycine (F-Gly NPs) and conjugated with methotrexate (MTX) (F-Gly-MTX NPs) were synthesized through a coprecipitation method followed by amidation reaction between the carboxylic acid end groups on MTX and the amine groups on the MNPs surface and studied its cytotoxic effect in vitro. The successful conjugating of MTX onto the nanoparticles (NPs) was confirmed by X-ray diffraction, thermogravimetric analysis, differential scanning calorimetry, Fourier transform infrared spectroscopy, vibrating sample magnetometer, and transmission electron microscopy techniques. The results showed that the average size was 46.82 ± 5.03 nm. This target drug delivery system is dependent on the release of the MTX within the lysosomal compartment. Hemolysis assay and cytotoxicity study results on HFF-2 and HEK-293 cell lines show that as prepared MNPs are biocompatible. The cytotoxicity of void of the MTX and F-Gly-MTX NPs were compared to each other by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay of the treated MCF-7 cell line. Enzymatic release studies exhibited the release of the MTX via peptide bond cleavage in the presence of proteinase K. These studies specify that the F-Gly-MTX NPs have a very remarkable anticancer effect, for breast cancer cell line. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1646-1654, 2018.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enzymatic stimuli‐responsive methotrexate‐conjugated magnetic nanoparticles for target delivery to breast cancer cells and release study in lysosomal condition

Nosrati

Mojtahedi

Danafar

et al. 2018

J Biomedical Materials Res

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“…UiO‐66 and NH 2 ‐UiO‐66 were chosen as adsorbents because of their high thermal stability, high chemical resistance toward polar solvents such as water, several alcohols, and organic solvents, easy functionalization and high capacity for drug adsorption . In related to our previous work to design and preparation of various type of nanoparticles for drug delivery and adsorbent systems . CUR was chosen as model drug because of its interesting properties.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of UiO‐66 metal organic framework as an effective sorbent for Curcumin's overdose

Molavi

Zamani

Aghajanzadeh

et al. 2018

Applied Organom Chemis

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112

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Metal organic frameworks (MOFs) UiO-66 (UiO stands for University of Oslo) and NH 2 -UiO-66 were prepared and characterized as sorbent (antidotal agents) for curcumin (CUR) adsorption. The structure of products were characterized by X-ray powder diffraction (XRD), Field emission scanning electron microscopy (FESEM), thermogravimetric analysis (TGA), Attenuated Total Reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), and N 2 adsorption-desorption measurements. FESEM showed NH 2 -UiO-66 displayed symmetrical crystals with triangular base pyramid morphology, with the particle size around 100 nm and uniform size distribution. Adsorption capacities of CUR/MOFs with different mass ratios in the feed were investigated in the present study, and this investigation revealed that when the CUR/MOFs with mass ratio was around 0.4, the absorption capacity of NH 2 -UiO-66 had tended to maximum. Although, functionalization reduced the specific surface area and free volume, introducing polar amine groups could improve the affinity of NH 2 -UiO-66 respect to CUR.Kinetic studies showed that the kinetic data are well fitted with the pseudo-second-order model. MTT assay revealed that MOFs at the concentration range of 0-560 μg/ml had no cytotoxic effect on the Human Foreskin Fibroblast normal cell line (HFF-2). These results suggest that these MOFs could be safe as sorbent for adsorb CUR from the body.

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“…UiO‐66‐NH 2 , UiO‐66‐GMA and UiO‐66‐EDA were synthesized under solvothermal conditions based on the methods described in our previous studies (see also the supporting information, section S1‐S3) …”

Section: Methodsmentioning

confidence: 99%

“…Metal–organic frameworks (MOFs), as an emerging class of highly crystalline and nanoporous materials built from various metal ions or metal clusters and organic linkers, have possessed great consideration in the past decade . The outstanding properties of MOFs such as ultra‐high surface area, well‐defined structures and pore size distribution, high pore volume, tunable composition and functionalization of pore surface, high porosity, and multiple topologies have made them promising candidates in different application including gas separation and storage, ion exchange, drug adsorption and delivery, chemical sensing, and catalysis …”

Section: Introductionmentioning

confidence: 99%

Zr‐Based MOFs with High Drug Loading for Adsorption Removal of Anti‐Cancer Drugs: A Potential Drug Storage

Molavi

Moghimi

Taheri

2020

Applied Organom Chemis

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A robust and highly water stable series of UiO‐66‐drived MOFs including UiO‐66‐NH2, glycidyl methacrylate functionalized UiO‐66‐NH2 (UiO‐66‐GMA) and ethylenediamine functionalized UiO‐66‐NH2 (UiO‐66‐EDA) were synthesized solvothermally and studied their adsorption performances toward two anti‐cancer drugs, methotrexate (MTX) and curcumin (CUR) in the case of overdose. It was found that functionalizing the surface of UiO‐66‐NH2 nanoparticles with different functional groups remarkably changes the adsorption capacity and the ideal adsorption selectivity of MTX over CUR. Particularly, the UiO‐66‐EDA exhibited the highest adsorption capacities for both drugs, 540.78 and 423.85 mg/g for MTX and CUR, respectively, because of the strong interaction between drug molecules and adsorbent via hydrogen bonding due to the existence of different polar functional groups. The kinetics of drugs adsorption was investigated by three well‐known kinetic models, which the output indicates that the adsorption of both drugs onto the synthesized MOFs follow the pseudo‐second‐order model. Moreover, it was found that the equilibrium adsorption results were well fitted with the Langmuir isotherm models, revealing that the adsorption of both drugs onto the synthesized MOFs is a monolayer adsorption process. Further investigation illustrated that the synthesized MOFs could be easily activated and reused after four successive adsorption–desorption cycles. The output of the present work is of main important for biomedical and environmental applications of MOFs as an outstanding adsorbent for adsorption removal of hazardous drugs from contaminated aqueous solutions.

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Preparation of Metal–Organic Frameworks UiO-66 for Adsorptive Removal of Methotrexate from Aqueous Solution

Cited by 165 publications

References 43 publications

Enzymatic stimuli‐responsive methotrexate‐conjugated magnetic nanoparticles for target delivery to breast cancer cells and release study in lysosomal condition

Enzymatic stimuli‐responsive methotrexate‐conjugated magnetic nanoparticles for target delivery to breast cancer cells and release study in lysosomal condition

Evaluation of UiO‐66 metal organic framework as an effective sorbent for Curcumin's overdose

Zr‐Based MOFs with High Drug Loading for Adsorption Removal of Anti‐Cancer Drugs: A Potential Drug Storage

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