Preparation of nano-hydroxyapatite/poly(l-lactide) biocomposite microspheres

Qiu, Xueyu; Han, Yadong; Zhuang, Xiuli; Chen, Xuesi; Li, Yuesheng; Jing, Xiabin

doi:10.1007/s11051-006-9158-6

Cited by 35 publications

(20 citation statements)

References 17 publications

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“…9 These studies covered nano-HA/PLA [268,[485][486][487][488][489][490][491][492] [34,575,576]. Besides, the data are available on the excellent biocompartibility of such nano-biocomposites [507].…”

Section: Calcium Orthophosphate Cement-based Biocomposites and Concretesmentioning

confidence: 99%

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Dorozhkin¹

2009

J Mater Sci

285

146

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Section: Calcium Orthophosphate Cement-based Biocomposites and Concretesmentioning

confidence: 99%

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Dorozhkin¹

2009

J Mater Sci

285

146

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“…[76] The hybrid particles could be applied for bone-repair applications, as coatings on implants, or as a building block for the scaffold fabrication that might be able to nucleate and grow new bone material. Although, such encapsulation within the polymeric matrix has already been reported in the form of microspheres, [66] encapsulation in the form of nanoparticles possess added advantages as they offer several possibilities for final applications owing to their large surface area and homogeneity. For the formulation of such hybrid particles, a reliable technique that allows a high homogeneity, solid content, and entrapment efficiency is decisive.…”

Section: Synthetic Biodegradable Polymer-based Nanoparticlesmentioning

confidence: 99%

Functional Hybrid Materials with Polymer Nanoparticles as Templates

Ethirajan

Landfester

2010

Chemistry A European J

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The use of polymeric nanoparticles as templates for producing inorganic materials is an intriguing approach as it offers the feasibility of synthesizing hybrid organic-inorganic functional materials for a broad spectrum of applications ranging from optoelectronics to biomedicine. The concept of using polymer nanoparticles as templates to produce hybrid materials has several advantages. On the one hand, the entire geometry of the nanoparticle can be used as a confined nano-environment to let the inorganic material grow inside the particle. On the other hand, the high surface area of nanoparticle can be exploited to let the inorganic material grow on the outside surface of the particles. One such application is presented here, in which polymer nanoparticles were used as biomimetic template to produce composite nanoparticles made of the bone mineral hydroxyapatite (HAP). The synthesized hybrid particle has a great potential to be used as regenerative filler or as scaffold for nucleation and growth of new bone material. In addition to be applied as coatings on implants, these nanoparticles also offer the feasibility of being injected directly into the damaged part or administered intravenously with functionalization. Within this overview, we will mainly focus on different polymer nanoparticles obtained by the miniemulsion technique and the different possibilities for them to be used as templates for the biomimetic mineralization of calcium phosphate in the aqueous phase.

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“…Several factors play role in the degradation kinetics of these polymers like the chemical composition, the molar mass, environmental conditions, the crystallinity, the hydrophobicity, etc. [5][6][7][8][9][10][11][12][13] The incorporation of hydroxyapatite (HAP) in these resorbable polyester matrixes can be obtained, for example, by blending preformed HAP in the polymeric matrix, [14,15] encapsulating HAP within microspheres, [16] by fabrication of PLGA/HAP composite scaffolds using the gas forming and the particulate leaching method for bone tissue engineering. [17] Surface grafting of degradable polymers onto the Biodegradable polymeric nanoparticles are employed as templates for the biomimetic mineralization of CaP in the aqueous phase.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Polymeric Nanoparticles as Templates for Biomimetic Mineralization of Calcium Phosphate

Ethirajan

Musyanovych

Landfester

2011

Macro Chemistry & Physics

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Biodegradable polymeric nanoparticles are employed as templates for the biomimetic mineralization of CaP in the aqueous phase. Particles in the sub‐µm range were prepared by a combination of solvent evaporation and miniemulsion techniques. The synthesized particles were subjected to degradation via random saponification. The anionic functional groups produced as a consequence of degradation due to production (ultrasonication step) and post treatment (hydrolysis) steps are used for the CaP mineralization. The composite particles were studied using HRSEM, TEM, and XRD. These polymer/CaP composite nanoparticles have a great potential to be used as a regenerative filler or as a scaffold for nucleation and growth of new bone material.

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Preparation of nano-hydroxyapatite/poly(l-lactide) biocomposite microspheres

Cited by 35 publications

References 17 publications

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Functional Hybrid Materials with Polymer Nanoparticles as Templates

Biodegradable Polymeric Nanoparticles as Templates for Biomimetic Mineralization of Calcium Phosphate

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