Preparation of nanostructured manganese-doped biphasic calcium phosphate powders via sol–gel method

Sopyan, Iis; Natasha, A.N.

doi:10.1007/s11581-009-0330-8

Cited by 24 publications

(22 citation statements)

References 13 publications

(32 reference statements)

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“…At the same speed and time, the crystallite size of T2 is lower (21.4 nm) than Silva et al [20] results (36.9 nm) which used precursors from CaH(PO) 4 and Ca(OH) 2 . In addition, the crystallite size (21 nm) obtained at M3 is higher compared to Silva et al [20] (14.3 nm) with Ca(CO) 3 and CaH(PO) 4 as precursors and lower than crystallite size obtained from CaCO 3 and (HN 4 )H 2 PO 4 precursors (35.5 nm). Lattice parameters along a and b axis of the milled powders are found expanded from the standard lattice parameter of HA (0.9418 nm) and inconsistent with the rotation speed and time.…”

Section: Methodsmentioning

confidence: 60%

Mechanochemical Synthesis of Hydroxyapatite Nanopowder: Effects of Rotation Speed and Milling Time on Powder Properties

Adzila

Sopyan

Hamdi

2011

AMM

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Abstract.Mechanochemical synthesis of two or more different precursors is a simple method to prepare metallic alloys, polymer and ceramic composite materials. This mechanical reaction based synthesis also has been employed to produce hydroxyapatite (HA) powder for bone implant application. In this present study, we employed mechanochemical method to synthesize hydroxyapatite nanopowder from dry mixture of calcium hydroxide (Ca(OH) 2 ) and di-ammonium hydrogen phosphate [(NH 4 ) 2 HPO 4 ] powders. The effect of mechanochemical process on powder properties was investigated. Three rotation speeds of 170 rpm (M1), 270 rpm (M2) and 370 rpm (M3) were chose with 15 hours milling time respectively. The milling time at 370 rpm (M3) was extended to 30 hours (T1) and 60 hours (T2). Characterization of nanopowders were accomplished by Fourier transform infrared (FTIR), X-ray diffraction (XRD), nanosizer analysis, field emission scanning electron microscope (FESEM) and transmission electron microscope (TEM). Rotation speed and milling time affected the obtained powders with nanocrystallite HA structure. The narrow peaks appeared with the incremental of crystallite size (9 -21 nm) and crystallinity (21-59%) when the rotation speed was increased to 370 rpm (M3). However, particle size distribution (322 -192 nm) was decreased with the rotation speed. Morphological evaluation indicated that the average particle size of resultant powder which consists of agglomerate crystals and irregular shapes reached about 17 -36 nm. The as synthesized nanopowder showed that 370 rpm at 15 hours of milling is the suitable parameter to be applied for hydroxyapatite nanopowder synthesis in mechanochemical method.

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Section: Methodsmentioning

confidence: 60%

Mechanochemical Synthesis of Hydroxyapatite Nanopowder: Effects of Rotation Speed and Milling Time on Powder Properties

Adzila

Sopyan

Hamdi

2011

AMM

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“…The peaks at 601 and 562 cm −1 correspond to the triply degenerate ν 4 , O-P-O bending mode and the band at 460 cm −1 is attributed to the doubly degenerate ν 2 , O-P-O bending mode. The bands at 1640 and 3441 cm −1 are assigned to the adsorbed water [23]. The low intensity hydroxyl group at 3553 cm −1 indicates the presence of HA/TCP [24].…”

Section: Ftir Analysesmentioning

confidence: 99%

Effect of Magnesium on the Mechanical and Bioactive Properties of Biphasic Calcium Phosphate

Kanchana¹,

Sekar²

2012

JMMCE

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Incorporation of trace elements into calcium phosphate structure is of great interest for the development of artificial bone implants. Biphasic calcium phosphate (BCP) composed of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) have been synthesized in the presence of magnesium (5 M%-20 M%) by gel method under physiological conditions. Crystallization of Mg-BCP in the gel medium mimics the Mg intake in the human body. Powder X-ray diffraction and Fourier transform infrared analyses confirmed that the Mg doping leads to the enrichment of β-TCP phase and suppresses the HA content in BCP. Nanoindentation studies indicate a significant decrease in hardness and elastic modulus values of BCP due to Mg doping. In vitro bioactivity study has confirmed the formation of apatite layer on the Mg doped samples making it suitable for bone replacement. The results suggest that the optimum Mg doping promotes the bioactivity which is perquisite for biomedical applications.

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“…20 Insufficient Mn in bone probably causes osteoporosis. 21 Previously Mn has been doped into HAp through solid-state reaction, 22 sol-gel, 23 wet chemical 16 and precipitation method. 24 However, still there exist no reports on Mn insertion into HAp via mechanical alloying (MA).…”

Section: Introductionmentioning

confidence: 99%

Mechanical preparation of nanocrystalline biocompatible single-phase Mn-doped A-type carbonated hydroxyapatite (A-cHAp): effect of Mn doping on microstructure

et al. 2015

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Nanocrystalline biocompatible single-phase Mn-doped A-type carbonated hydroxyapatite (A-cHAp) powder has been synthesized by mechanical alloying of a stoichiometric mixture of CaCO3, CaHPO4·2H2O and MnO powder for 10 h at room temperature under open air. The A-type carbonation in HAp (substitution of CO3(2-) for OH(-)) is confirmed by FTIR analysis. Microstructure characterization in terms of lattice imperfections and phase quantification of ball milled samples are made by analyzing XRD patterns employing the Rietveld structure refinement method. Rietveld analysis of XRD patterns recorded from Mn-doped HAp samples has been used to locate Mn(2+) cations in HAp. The Ca2 vacancy site is found to be more favorable for Mn substitution. Microstructure characterization by HRTEM corroborates the findings of the X-ray analysis where the presence of a significant amount of amorphous phase of HAp analogous to indigenous bone mineral is clearly found. MTT assay shows sufficiently high percentage cell viability confirming the cytocompatibility of the sample.

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Preparation of nanostructured manganese-doped biphasic calcium phosphate powders via sol–gel method

Cited by 24 publications

References 13 publications

Mechanochemical Synthesis of Hydroxyapatite Nanopowder: Effects of Rotation Speed and Milling Time on Powder Properties

Mechanochemical Synthesis of Hydroxyapatite Nanopowder: Effects of Rotation Speed and Milling Time on Powder Properties

Effect of Magnesium on the Mechanical and Bioactive Properties of Biphasic Calcium Phosphate

Mechanical preparation of nanocrystalline biocompatible single-phase Mn-doped A-type carbonated hydroxyapatite (A-cHAp): effect of Mn doping on microstructure

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